Immune response in cerebral ischemic injury: interaction and therapeutic potential DOI
Weijia Gao

New discovery., Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Nov. 20, 2024

Cerebral ischemia primarily results from vascular stenosis or blockage, which activates inflammatory cells and triggers an immune response. An excessive response can exacerbate the damage caused by cerebral ischemia. In this review, keywords “immune response” “cerebral ischemia” were entered into PubMed database, yielding 241 articles, of 141 included in analysis. Relevant literature 2021 to 2024 was summarized, classified, synthesized delineate advancements field. Consequently, exploring basic physiology responses brain injury, we found that microglia phagocytose dead neurons, thereby ameliorating ischemic injury. However, accumulate attack blood vessels nerve following ischemia, resulting additional damage. As a result, targeting CD8 T cells, astrocytes, superoxide dismutase (SOD), interleukin-10 (IL-10), tumor necrosis factor (TNF), NLRP3, NF-κB signaling pathway help mitigate Furthermore, specific mechanisms efficacy therapeutic drugs recent years analyzed, revealing their potential repair blood-brain barrier, endothelial while also reducing infarct size responses. Together, highlight particularly microglia, present new breakthroughs neuron phagocytosis, improvement responses, reduction These findings provide clinicians researchers with cutting-edge references for treatment strategies.

Language: Английский

Microglial plasticity governed by state-specific enhancer landscapes DOI Creative Commons
Nicole Hamagami,

Dvita Kapadia,

Nora Abduljawad

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

SUMMARY Single-cell transcriptomic studies have identified distinct microglial subpopulations with shared and divergent gene signatures across development, aging disease. Whether these subsets represent ontogenically separate lineages of cells, or they are manifestations plastic changes states downstream some converging signals is unknown. Furthermore, despite the well-established role enhancer landscapes underlying identity microglia, to what extent histone modifications DNA methylation regulate state switches at enhancers not been defined. Here, using genetic fate mapping, we demonstrate common embryonic origin proliferative-region-associated microglia (PAM) enriched in developing white matter, track their dynamic transitions into disease-associated (DAM) matter-associated (WAM) disease contexts, respectively. This study links spatiotemporally discrete through epigenomic plasticity, while revealing state-specific modification profiles that govern health

Language: Английский

Citations

1
White matter aging and its impact on brain function DOI Creative Commons
Janos Groh, Mikael Simons

Neuron, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Aging has a detrimental impact on white matter, resulting in reduced volume, compromised structural integrity of myelinated axons, and an increase matter hyperintensities. These changes are closely linked to cognitive decline neurological disabilities. The deterioration myelin its diminished ability regenerate as we age further contribute the progression neurodegenerative disorders. Understanding these is crucial for devising effective disease prevention strategies. Here, will discuss alterations that occur with aging examine cellular molecular mechanisms driving aging-related transformations. We highlight how progressive disruption may initiate self-perpetuating cycle inflammation neural damage.

Language: Английский

Citations

4
The immunology of stroke and dementia DOI
Costantino Iadecola, Josef Anrather

Immunity, Journal Year: 2025, Volume and Issue: 58(1), P. 18 - 39

Published: Jan. 1, 2025

Language: Английский

Citations

0
Roadmap for alleviating the manifestations of ageing in the cardiovascular system DOI
Luca Liberale, Simon Tual‐Chalot, Simon Sedej

et al.

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Language: Английский

Citations

0
Senescence- and Immunity-Related Changes in the Central Nervous System: A Comprehensive Review DOI Creative Commons

Haiwen Feng,

Junjin Li,

Hongda Wang

et al.

Aging and Disease, Journal Year: 2024, Volume and Issue: unknown, P. 0 - 0

Published: Jan. 1, 2024

Senescence is a cellular state characterized by an irreversible halt in the cell cycle, accompanied alterations morphology, function, and secretion. Senescent cells release plethora of inflammatory growth factors, extracellular matrix proteins, other bioactive substances, collectively known as senescence-associated secretory phenotype (SASP). These excreted substances serve crucial mediators senescent tissues, while secretion SASP neurons glial central nervous system modulates activity immune cells. also influence physiological activities various system. Further, interaction between senescence regulation affects pathological processes Herein, we explore role underlying embryonic development, aging, degeneration, injury system, through response. elucidate proposing new theoretical foundation for treating diseases.

Language: Английский

Citations

1
An anti-aging vaccine: BCG turns back the clock on remyelination failure DOI
Janssen M. Kotah, Bart J. L. Eggen

Immunity, Journal Year: 2024, Volume and Issue: 57(9), P. 2005 - 2007

Published: Sept. 1, 2024

Language: Английский

Citations

0
Immune response in cerebral ischemic injury: interaction and therapeutic potential DOI
Weijia Gao

New discovery., Journal Year: 2024, Volume and Issue: unknown, P. 1 - 25

Published: Nov. 20, 2024

Cerebral ischemia primarily results from vascular stenosis or blockage, which activates inflammatory cells and triggers an immune response. An excessive response can exacerbate the damage caused by cerebral ischemia. In this review, keywords “immune response” “cerebral ischemia” were entered into PubMed database, yielding 241 articles, of 141 included in analysis. Relevant literature 2021 to 2024 was summarized, classified, synthesized delineate advancements field. Consequently, exploring basic physiology responses brain injury, we found that microglia phagocytose dead neurons, thereby ameliorating ischemic injury. However, accumulate attack blood vessels nerve following ischemia, resulting additional damage. As a result, targeting CD8 T cells, astrocytes, superoxide dismutase (SOD), interleukin-10 (IL-10), tumor necrosis factor (TNF), NLRP3, NF-κB signaling pathway help mitigate Furthermore, specific mechanisms efficacy therapeutic drugs recent years analyzed, revealing their potential repair blood-brain barrier, endothelial while also reducing infarct size responses. Together, highlight particularly microglia, present new breakthroughs neuron phagocytosis, improvement responses, reduction These findings provide clinicians researchers with cutting-edge references for treatment strategies.

Language: Английский

Citations

0