Treating cancerous cells with a continuous release of virus particles DOI Open Access
Ahmed Hussein Msmali, Mark Nelson, Fahad Al Saadi

et al.

ANZIAM Journal, Journal Year: 2022, Volume and Issue: 63, P. C195 - C207

Published: Dec. 7, 2022

We investigate a model for the treatment of tumour through application virus. In original it was assumed that virus particles are released only at one time. Such strategy cannot eliminate tumour, as tumour-free steady-state solution is unstable except pathological circumstances in which does not grow and/or die. extend by allowing to be treated continuous release particles. show scaled delivery rate has two threshold values: below lower system evolves stable periodic solution; above higher eradicated. References C. E. Engeland, J. P. W. Heidbuechel, R. Araujo, and A. L. Jenner. Improving immunovirotherapies: The intersection mathematical modelling experiments. ImmunoInformatics 6 (2022), p. 100011. doi: 10.1016/j.immuno.2022.100011 Jenner, F. Coster, S. Kim, Frascoli. Treating cancerous cells with viruses. Lett. Biomath. 5.2 (2018), S117–S136. 10.1080/23737867.2018.1440977 Frascoli, C.-O. Yun, Kim. Optimising hydrogel profiles viro-immunotherapy using oncolytic adenovirus expressing IL-12 GM-CSF immature dendritic cells. Appl. Sci. 10.8 (2020). 10.3390/app10082872 Tian. replicability virus: Defining conditions tumor virotherapy. Math. Bio. Eng. 8.3 (2011), pp. 841–860. 10.3934/mbe.2011.8.841

Language: Английский

Treating cancerous cells with a continuous release of virus particles DOI Open Access
Ahmed Hussein Msmali, Mark Nelson, Fahad Al Saadi

et al.

ANZIAM Journal, Journal Year: 2022, Volume and Issue: 63, P. C195 - C207

Published: Dec. 7, 2022

We investigate a model for the treatment of tumour through application virus. In original it was assumed that virus particles are released only at one time. Such strategy cannot eliminate tumour, as tumour-free steady-state solution is unstable except pathological circumstances in which does not grow and/or die. extend by allowing to be treated continuous release particles. show scaled delivery rate has two threshold values: below lower system evolves stable periodic solution; above higher eradicated. References C. E. Engeland, J. P. W. Heidbuechel, R. Araujo, and A. L. Jenner. Improving immunovirotherapies: The intersection mathematical modelling experiments. ImmunoInformatics 6 (2022), p. 100011. doi: 10.1016/j.immuno.2022.100011 Jenner, F. Coster, S. Kim, Frascoli. Treating cancerous cells with viruses. Lett. Biomath. 5.2 (2018), S117–S136. 10.1080/23737867.2018.1440977 Frascoli, C.-O. Yun, Kim. Optimising hydrogel profiles viro-immunotherapy using oncolytic adenovirus expressing IL-12 GM-CSF immature dendritic cells. Appl. Sci. 10.8 (2020). 10.3390/app10082872 Tian. replicability virus: Defining conditions tumor virotherapy. Math. Bio. Eng. 8.3 (2011), pp. 841–860. 10.3934/mbe.2011.8.841

Language: Английский

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