Effects of trehalose on bone healing, physical function, and pain in patients with pertrochanteric fractures: a randomized controlled trial protocol DOI Creative Commons
Reza Zandi,

Hosna Omidi Razani,

Amir Mehrvar

et al.

Trials, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 18, 2024

Language: Английский

Insights into computer-aided EEG signal processing for traumatic brain injury assessment: A review DOI

Farzaneh Manzari,

Peyvand Ghaderyan

Measurement, Journal Year: 2025, Volume and Issue: unknown, P. 117279 - 117279

Published: March 1, 2025

Language: Английский

Citations

0
Trehalose Ameliorates Zebrafish Emotional and Social Deficits Caused by CLN8 Dysfunction DOI Creative Commons
Rosario Licitra, Stefania Della Vecchia,

Lorenzo Santucci

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(1), P. 55 - 55

Published: Jan. 5, 2025

CLN8 and other neuronal ceroid lipofuscinoses (NCLs) often lead to cognitive decline, emotional disturbances, social deficits, worsening with disease progression. Disrupted lysosomal pH, impaired autophagy, defective dendritic arborization contribute these symptoms. Using a cln8−/− zebrafish model, we identified significant impairments in locomotion, anxiety, aggression, along subtle deficits interactions, positioning as useful model for therapeutic studies NCL. Our findings show that trehalose, an autophagy enhancer, ameliorates modestly improves behavior predator avoidance mutant zebrafish. This finding aligns animal models clinical reports suggestive of behavioral improvements NCL patients. Trehalose holds promise agent CLN8, warranting further research into its neuroprotective mechanisms applications.

Language: Английский

Citations

0
Trehalose: Neuroprotective Effects and Mechanisms—An Updated Review DOI Creative Commons

Borislav Sevriev,

Simeonka Dimitrova,

Gabriela Kehayova

et al.

NeuroSci, Journal Year: 2024, Volume and Issue: 5(4), P. 429 - 444

Published: Oct. 12, 2024

Trehalose is a naturally occurring disaccharide that has recently gained significant attention for its neuroprotective properties in various models of neurodegeneration. This review provides an overview available experimental data on the beneficial trehalose central nervous system pathological conditions. Trehalose's impact neuronal cell survival and function was also examined. As result, we identified trehalose's neuroprotection includes autophagy modulation as well capability to stabilize proteins inhibit formation misfolded ones. Moreover, mitigates oxidative stress-induced damage by stabilizing cellular membranes modulating mitochondrial function. Furthermore, attenuates excitotoxicity-induced neuroinflammation suppressing pro-inflammatory cytokine release inhibiting inflammasome activation. A possible connection with gut-brain axis These findings highlight potential therapeutic effects neurodegenerative diseases. According conclusions drawn from this study, promising agent result distinct mechanism action, which makes compound candidate further research development strategies combat promote neurological

Language: Английский

Citations

2
Effects of trehalose on bone healing, physical function, and pain in patients with pertrochanteric fractures: a randomized controlled trial protocol DOI Creative Commons
Reza Zandi,

Hosna Omidi Razani,

Amir Mehrvar

et al.

Trials, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 18, 2024

Language: Английский

Citations

0