Metabolomic Profiling of Pogostemon cablin Reveals Disruption of Secondary Metabolite Biosynthesis Induced by Corynespora cassiicola Infection DOI Open Access
Renqiang Liao, Yangyang Chen, Limin Li

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3680 - 3680

Published: April 13, 2025

Pogostemon cablin (patchouli) is an economically important aromatic plant widely used in the fragrance and pharmaceutical industries. This study investigates effects of Corynespora leaf spot disease (CLSD) on metabolic profiles patchouli alcohol content leaves. Utilizing gas chromatography-mass spectrometry (GC-MS), real-time PCR (qPCR), comprehensive non-targeted metabolomic analyses (HS-SPME-GC-MS LC-MS/MS), we compared diseased (LD-TJ) healthy (CK) Results revealed a significant 51% reduction CLSD-infected leaves, which was correlated with 94% decrease expression patchoulol synthase (PTS)-encoding gene (p < 0.01) 79% farnesyl pyrophosphate (FPPS)-encoding 0.05), both critical for terpenoid biosynthesis. Metabolomic identified extensive disruptions volatile non-volatile compounds, majority differential abundance metabolites (DAMs) being downregulated. Key pathways, including beta-alanine metabolism nicotinate/nicotinamide metabolism, were notably affected, indicating broader instability. Additionally, crucial transcription factors involved biosynthesis significantly downregulated, potential mechanism by C. cassiicola may compromise quality through modulation host processes. These findings underscore urgent need to develop disease-resistant P. cultivars genetic engineering enhance sustainability productivity this valuable industrial crop.

Language: Английский

3D printed sodium Alginate-Gelatin hydrogel loaded with Santalum album oil as an antibacterial Full-Thickness wound healing and scar reduction Scaffold: In vitro and in vivo study DOI

Shahabaj S Mujawar,

Gajanan K Arbade,

Sonali Rukwal

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125164 - 125164

Published: Jan. 5, 2025

Language: Английский

Citations

1
Sources, bioactivities, and industrial importance of plant-based aroma compounds DOI
Javed Ahamad

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 15 - 24

Published: Jan. 1, 2025

Language: Английский

Citations

0
The potential of medicinal plants in tuberculosis treatment: Indigenous plants used by the Anak Dalam tribe of Jambi, Indonesia DOI
Muhaimin Muhaimin, Uce Lestari,

Rifanza Hirzan

et al.

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 180, P. 688 - 709

Published: April 3, 2025

Language: Английский

Citations

0
Metabolomic Profiling of Pogostemon cablin Reveals Disruption of Secondary Metabolite Biosynthesis Induced by Corynespora cassiicola Infection DOI Open Access
Renqiang Liao, Yangyang Chen, Limin Li

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3680 - 3680

Published: April 13, 2025

Pogostemon cablin (patchouli) is an economically important aromatic plant widely used in the fragrance and pharmaceutical industries. This study investigates effects of Corynespora leaf spot disease (CLSD) on metabolic profiles patchouli alcohol content leaves. Utilizing gas chromatography-mass spectrometry (GC-MS), real-time PCR (qPCR), comprehensive non-targeted metabolomic analyses (HS-SPME-GC-MS LC-MS/MS), we compared diseased (LD-TJ) healthy (CK) Results revealed a significant 51% reduction CLSD-infected leaves, which was correlated with 94% decrease expression patchoulol synthase (PTS)-encoding gene (p < 0.01) 79% farnesyl pyrophosphate (FPPS)-encoding 0.05), both critical for terpenoid biosynthesis. Metabolomic identified extensive disruptions volatile non-volatile compounds, majority differential abundance metabolites (DAMs) being downregulated. Key pathways, including beta-alanine metabolism nicotinate/nicotinamide metabolism, were notably affected, indicating broader instability. Additionally, crucial transcription factors involved biosynthesis significantly downregulated, potential mechanism by C. cassiicola may compromise quality through modulation host processes. These findings underscore urgent need to develop disease-resistant P. cultivars genetic engineering enhance sustainability productivity this valuable industrial crop.

Language: Английский

Citations

0