Essential Oils from Citrus Peels Promote Calcium Overload-Induced Calcicoptosis in U251 Cells DOI Creative Commons
Yurong Li,

Juanjuan Wei,

Zimao Ye

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 11 - 11

Published: Dec. 25, 2024

Citrus peel essential oils (CPEOs) have demonstrated substantial medicinal potential for glioblastoma treatment because of their extensive antitumor effects, low drug resistance, and ability to cross the human blood-brain barrier. In this study, chemical compositions five CPEOs were analyzed via gas chromatography-mass spectrometry (GC-MS). CCK8 assays used evaluate inhibit U251 cells, XLB RA selected further investigation. Through wound healing cell cycle apoptosis analyses flow cytometry, it was revealed that these inhibited migration, arrested at G1/G0, induced with similar levels inhibition. After treatment, intracellular Ca2+ content reactive oxygen species in cells increased significantly, whereas mitochondrial membrane decreased. Additionally, antioxidant enzyme system (SOD, POD, CAT, GR) nonenzymatic defense (GSH) inhibited, leading an increase lipid peroxidation. qRT-PCR indicated significant upregulation calcium ion signaling pathways apoptosis-related genes. activation calcicoptosis-related indicators by could be reversed inhibitor confirming both tumors activating pathways. These findings highlight immense healthcare pharmaceutical applications not only providing a scientific basis application but also offering new insights development novel drugs.

Language: Английский

Antimicrobial activity and mechanism of protocatechualdehyde against Alicyclobacillus spp. and its effect on apple juice physicochemical properties DOI

Jianrui Qi,

Huan Xu, Xudong Wu

et al.

Food Control, Journal Year: 2025, Volume and Issue: unknown, P. 111289 - 111289

Published: March 1, 2025

Language: Английский

Citations

0
Rationally designed electrosprayed particles for encapsulation of essential oils, flavors, essential fatty acids, and antibacterials DOI
Yao Hu, Sai Liu, Gareth R. Williams

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 217 - 237

Published: Jan. 1, 2025

Language: Английский

Citations

0
Essential Oils from Citrus Peels Promote Calcium Overload-Induced Calcicoptosis in U251 Cells DOI Creative Commons
Yurong Li,

Juanjuan Wei,

Zimao Ye

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 11 - 11

Published: Dec. 25, 2024

Citrus peel essential oils (CPEOs) have demonstrated substantial medicinal potential for glioblastoma treatment because of their extensive antitumor effects, low drug resistance, and ability to cross the human blood-brain barrier. In this study, chemical compositions five CPEOs were analyzed via gas chromatography-mass spectrometry (GC-MS). CCK8 assays used evaluate inhibit U251 cells, XLB RA selected further investigation. Through wound healing cell cycle apoptosis analyses flow cytometry, it was revealed that these inhibited migration, arrested at G1/G0, induced with similar levels inhibition. After treatment, intracellular Ca2+ content reactive oxygen species in cells increased significantly, whereas mitochondrial membrane decreased. Additionally, antioxidant enzyme system (SOD, POD, CAT, GR) nonenzymatic defense (GSH) inhibited, leading an increase lipid peroxidation. qRT-PCR indicated significant upregulation calcium ion signaling pathways apoptosis-related genes. activation calcicoptosis-related indicators by could be reversed inhibitor confirming both tumors activating pathways. These findings highlight immense healthcare pharmaceutical applications not only providing a scientific basis application but also offering new insights development novel drugs.

Language: Английский

Citations

0