Biobased Physicochemical Reversible Dual-Cross-Linked Hydrogel: Self-Healing, Antibacterial, Antioxidant, and Hemostatic Properties for Diabetic Wound Healing

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Skin wound healing remains challenging due to a lack of ideal dressings suitable for acute and chronic wounds. This study introduced biocompatible hydrogel dressing, synthesized through green chemistry approach, specifically designed meet the dual needs care. The innovative strategy utilized sustainable biomaterials, soy protein, vanillin, construct physical–reversible chemical dual-cross-linked exhibiting high mechanical strength, excellent adhesion, toughness. Schiff base reversible covalent bonds enabled rapid self-healing within 10 s, significantly improving durability. In rat liver hemorrhage model, rapidly sealed wounds, achieving effective hemostasis, indicating great potential Furthermore, vanillin imparted with antimicrobial antioxidant properties, effectively accelerating diabetic healing. safe efficient advanced biobased offers novel perspective treatment holds significant promise clinical applications.

Language: Английский

High water retention bio-mass adhesives inspired by hydrogels for engineering applications

Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 224, P. 120283 - 120283

Published: Dec. 13, 2024

Language: Английский