Journal of Materials Chemistry B,
Journal Year:
2023,
Volume and Issue:
11(30), P. 7024 - 7040
Published: Jan. 1, 2023
Alzheimer's
disease
(AD)
is
a
neurodegenerative
disorder
affecting
44
million
people
worldwide.
Although
many
issues
(pathogenesis,
genetics,
clinical
features,
and
pathological
aspects)
are
still
unknown,
this
characterized
by
noticeable
hallmarks
such
as
the
formation
of
β-amyloid
plaques,
hyperphosphorylation
tau
proteins,
overproduction
reactive
oxygen
species,
reduction
acetylcholine
levels.
There
no
cure
for
AD
current
treatments
aimed
at
regulating
cholinesterase
levels,
attenuating
symptoms
temporarily
rather
than
preventing
progression.
In
context,
coordination
compounds
regarded
promissing
tool
in
treatment
and/or
diagnosis.
Coordination
(discrete
or
polymeric)
possess
several
features
that
make
them
an
interesting
option
developing
new
drugs
(good
biocompatibility,
porosity,
synergetic
effects
ligand-metal,
fluorescence,
particle
size,
homogeneity,
monodispersity,
etc.).
This
review
discusses
recent
progress
development
novel
discrete
metal
complexes
metal-organic
frameworks
(MOFs)
treatment,
diagnosis
theragnosis
AD.
These
advanced
therapies
organized
according
to
target:
Aβ
peptides,
hyperphosphorylated
synaptic
dysfunction,
mitochondrial
failure
with
subsequent
oxidative
stress.
ACS Applied Nano Materials,
Journal Year:
2022,
Volume and Issue:
5(8), P. 10151 - 10166
Published: Aug. 9, 2022
Today,
magnetic
resonance
imaging
(MRI)
is
one
of
the
most
widely
applied
noninvasive
clinical
modalities
with
excellent
applicability
in
bio-
and
nanomedicine,
particularly
specific
detecting
high-quality
three-dimensional
tumors/cancers.
In
this
context,
design
efficient
nanoscale
contrast
agents
(NCAs)
for
MRI
high
relaxivity
specificity/selectivity
has
garnered
immense
interest
deploying
a
variety
innovatively
designed
nanostructures.
Some
important
characteristics
NCAs
such
as
biocompatibility,
improved
relaxivity,
dispersibility,
targeting,
low
toxicity
make
them
ideal
candidates
imaging/biosensing
applications.
The
hybridization
surface
functionalization/modification
these
materials
by
applying
suitable
functional
groups/agents
can
help
to
improve
their
properties
multifunctionality.
However,
there
still
long
way
go
applications
nanoagents
serve
substitute
Gd-based
or
other
commercial
materials.
Importantly,
nanotoxicological
biosafety
issues
need
be
systematically
addressed
both
at
pre-
stages;
construction
smart
multifunctional
diagnostic
potentials
thus
warranted.
Herein,
recent
advancements
related
are
deliberated,
focusing
on
challenges
future
directions.
Applied Organometallic Chemistry,
Journal Year:
2022,
Volume and Issue:
37(3)
Published: Dec. 14, 2022
Recently,
metal‐organic
frameworks
(MOFs)
have
received
a
lot
of
interest
for
application
in
many
fields
ranging
from
catalysis,
energy
storage,
and
gas
sensing
to
chemosensory
biomedicine
owed
their
flexible
composition,
tunable
porosity,
easy
functionalization
ability.
In
particular,
nanoscale
MOFs
been
broadly
investigated
as
carriers
the
delivery
therapeutics
cancerous
organs
high
encapsulating
capacity
controlled
cargo
release,
versatility,
biodegradability,
good
biocompatibility.
Several
methods
such
solvothermal,
mechanochemical,
electrochemical,
microwave,
ultrasound
utilized
fabricate
via
custom‐made
synthesis.
Many
efforts
made
functionalize
through
“post‐synthetic
modification,”
by
adjusting
nature,
size,
charge
linkers
or
tuning
its
main
components.
Herein,
comprehensive
literature
review
on
recent
papers
dealing
with
drug‐loaded
detection
treatment
cancer
well
bacterial,
fungal,
viral
infections
is
presented.
Different
types
applied
drug
systems
biosensing
platforms
are
described.
Furthermore,
perspectives
challenges
future
research
field,
particularly
therapy,
discussed.
Thus,
very
limited
available
vitro
vivo
toxicity
MOFs.
Besides,
biological
stability
long‐term
safety
crucial
factors
that
should
be
further
investigated.
Based
reviewed
papers,
zeolite
imidazolate
framework
(ZIF)
Materials
Institute
Lavoisier
(MIL)
families
focus
diagnosis
applications,
respectively,
while
exhibited
antibacterial
antifungal
properties
regardless
cargo.
Regenerative Biomaterials,
Journal Year:
2023,
Volume and Issue:
11
Published: Dec. 23, 2023
Abstract
Metal–organic
frameworks
(MOFs)
have
a
high
specific
surface
area,
adjustable
pores
and
can
be
used
to
obtain
functional
porous
materials
with
diverse
well-ordered
structures
through
coordination
self-assembly,
which
has
intrigued
wide
interest
in
broad
range
of
disciplines.
In
the
arena
biomedical
engineering,
functionalized
modification
MOFs
produced
drug
carriers
excellent
dispersion
functionalities
such
as
target
delivery
response
release,
promising
applications
bio-detection,
disease
therapy,
tissue
healing,
other
areas.
This
review
summarizes
present
state
research
on
functionalization
by
physical
binding
or
chemical
cross-linking
small
molecules,
polymers,
biomacromolecules,
hydrogels
evaluates
role
approach
boosting
reactivity
materials.
On
this
basis,
application
composites
engineering
fields
delivery,
repair,
treatment,
bio-detection
imaging
is
surveyed,
development
trend
prospects
an
important
new
class
field
are
anticipated,
may
provide
some
inspiration
reference
for
further
MOF
bio-medical
applications.
Regenerative Biomaterials,
Journal Year:
2024,
Volume and Issue:
11
Published: Jan. 1, 2024
Abstract
With
the
rapid
development
of
materials
science
and
tissue
engineering,
a
variety
biomaterials
have
been
used
to
construct
engineering
scaffolds.
Due
performance
limitations
single
materials,
functional
composite
attracted
great
attention
as
tools
improve
effectiveness
biological
scaffolds
for
repair.
In
recent
years,
metal-organic
frameworks
(MOFs)
shown
promise
application
in
because
their
high
specific
surface
area,
porosity,
biocompatibility,
appropriate
environmental
sensitivities
other
advantages.
This
review
introduces
methods
construction
MOFs-based
describes
functions
mechanisms
MOFs
repairing
damaged
tissue.
The
latest
composites
applications
different
tissues
are
discussed.
Finally,
challenges
future
prospects
using
summarized.
aim
this
is
show
potential
field
stimulate
further
innovation
promising
area.
Advanced Science,
Journal Year:
2024,
Volume and Issue:
11(38)
Published: Aug. 5, 2024
As
a
form
of
dementia,
Alzheimer's
disease
(AD)
suffers
from
no
efficacious
cure,
yet
AD
treatment
is
still
imperative,
as
it
ameliorates
the
symptoms
or
prevents
deteriorating
maintains
current
status
to
longest
extent.
The
human
brain
most
sensitive
and
complex
organ
in
body,
which
protected
by
blood-brain
barrier
(BBB).
This
induces
difficulty
curing
drugs
nanomaterials
that
are
much
inhibited
reaching
lesion
site.
Thus,
BBB
crossing
capability
drug
delivery
system
remains
significant
challenge
development
neurological
therapeutics.
Fortunately,
nano-enabled
systems
possess
promising
potential
achieve
multifunctional
diagnostics/therapeutics
against
various
targets
owing
their
intriguing
advantages
nanocarriers,
including
easy
multifunctionalization
on
surfaces,
high
surface-to-volume
ratio
with
large
payloads,
ability
cross
BBB,
making
them
capable
conquering
limitations
conventional
candidates.
review,
focuses
diagnosis
treatment,
will
provide
an
insightful
vision
conducive
AD-related
nanomaterials.
Journal of Materials Chemistry A,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
Recent
advancements
pertaining
to
the
applications
of
MXenes
and
MOFs
in
paper-based
sensors
are
discussed,
focusing
on
challenges
future
perspectives.
Advanced Functional Materials,
Journal Year:
2023,
Volume and Issue:
34(3)
Published: Oct. 15, 2023
Abstract
Recently,
neurological
disorders
have
led
to
a
growing
global
burden
of
fatalities
and
disabilities.
The
limited
capacity
for
natural
self‐regeneration
poses
significant
challenge
in
repairing
nervous
system
injuries,
which
is
closely
related
the
complex
microenvironment
nonregenerative
nature
neurons.
Metal–organic
frameworks
(MOFs),
with
their
distinctive
structure
properties
including
high
surface
area,
porosity,
tunability,
stimuli‐responsive
behavior,
biocompatibility,
biodegradability,
stand
as
an
auspicious
platform
devising
therapeutic
strategies
aiming
at
nerve
regeneration
repair.
By
taking
advantage
these
characteristics,
researchers
opportunity
explore
innovative
methods
endogenous
stimulation,
magnetic
response
therapy,
phototherapy,
ultrasound
drug
delivery
systems
treatment
diseases.
Moreover,
MOFs‐based
stem
cell
therapy
also
developed
inhibit
neuroinflammation
oxidative
stress,
promote
axon
growth,
regulate
differentiation,
regeneration,
finally
restore
function
injured
nerves.
In
this
paper,
preparation
strategy
biological
characteristics
MOFs,
highlighting
applications
injuries
treating
neural
cells
presented.
Finally,
outlook
on
future
development
challenges
field
neuroscience
concerning
MOFs
provided.
