Physicochemical and in vitro characterization of Agarose based nanocarriers incorporated with Graphene Quantum Dots/ α-Fe2O3 for targeted drug delivery of Quercetin to liver cancer treatment

Materials Chemistry and Physics, Journal Year: 2024, Volume and Issue: 320, P. 129333 - 129333

Published: May 3, 2024

Language: Английский

---

Design, fabrication and biocompatibility assessment of a carbon cloth-integrated MoS2-CuS-GO thermoresponsive hydrogel microsystem for photothermal-triggered benvitimod delivery

Nano Materials Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

---

Influence of zinc acetate on HPMC/CMC polymer blend: Investigation of their composites’ structural, optical, and dielectric properties for dielectric capacitor applications

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 171, P. 113536 - 113536

Published: Nov. 13, 2024

Language: Английский

---

Charge transfer-driven enhanced lithium extraction using poly(acrylic) acid-modified layered double hydroxide

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 494, P. 152939 - 152939

Published: June 15, 2024

Language: Английский

---

Nanotechnology revolutionizing osteosarcoma treatment: Advances in targeted kinase inhibitors

Nanotechnology Reviews, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 1, 2025

Abstract Osteosarcoma (OS) is the most frequent primary malignant bone tumor in adolescents and young adults. Despite advances therapy, OS remains an ominous problem because of its high metastatic potential, resistance to standard great physical, psychological, financial burden on patients. Available treatment options like surgery high-dose chemotherapy are limited by chemotoxicity, multimed resistance, adverse effects quality life Extrapolated from wide array vitro vivo studies, application kinase inhibitors targeting oncogenic signaling pathways, such as insulin-like growth factor 1 receptor, PDGFR, PI3K/AKT/mTOR pathway, appears quite promising. However, patients plagued with challenges poor bioavailability, off-target effects, mechanisms, which prevent clinical application. This review explores how nanotechnology beginning meet these challenges. Liposomes, polymeric nanoparticles, metallic nanoparticles among that provide new solutions for delivery bioavailability inhibitors, reducing systemic toxicity enhancing therapeutic accuracy. Active or passive enabled nanocarriers, enable drugs specifically act tissues while minimizing healthy cells. Additionally, diagnostic functionalities combined into theranostic platforms through pave way personalized medicine approaches. Nanoparticle-based have shown efficacy preclinical setting overcome drug improve targeting, sustained release drug. These dramatic improving outcomes at much less than currently available treatments. shows need further exploration bridge exciting findings practice. Future studies should seek optimize nanoparticle design evade enhance target specificity, reduce time-dependent toxicity. Further, incorporation a strategy has possibility changing treated bringing promise better patient life.

Language: Английский

---

Doping Detection Based on the Nanoscale: Biosensing Mechanisms and Applications of Two-Dimensional Materials

Biosensors, Journal Year: 2025, Volume and Issue: 15(4), P. 227 - 227

Published: April 3, 2025

Doping undermines fairness in sports and threatens athlete health, while conventional detection methods like LC-MS GC-MS face challenges such as complex procedures, matrix interferences, lengthy processing times, limiting on-site applications. Two-dimensional (2D) materials, including graphene, MoS2, metal–organic frameworks (MOFs), offer promising solutions due to their large surface areas, tunable electronic structures, special interactions with doping agents, hydrogen bonding, π-π stacking, electrostatic forces. These materials enable signal transduction through changes conductivity or fluorescence quenching. This review highlights the use of 2D detection. For example, reduced graphene oxide–MOF composites show high sensitivity for detecting anabolic steroids testosterone, NiO/NGO nanocomposites exhibit strong selectivity stimulants ephedrine. However, environmental instability production costs hinder widespread application. Future efforts should focus on improving material stability chemical modifications, reducing costs, integrating these into advanced systems machine learning. Such advancements could revolutionize detection, ensuring protecting health.

Language: Английский

---

Advancements in the use of cancer nanovaccines: Comprehensive insights with focus on lung and colon cancer

Nanotechnology Reviews, Journal Year: 2025, Volume and Issue: 14(1)

Published: Jan. 1, 2025

Abstract Cancer remains a prima facie cause of morbidity and mortality globally, necessitating efficient medicaments. The inter-mechanisms between immune system cascade the ability cancer cells to evade immunological responses pose significant challenge in developing effective treatments despite advanced immunotherapy treatments. Intervention nanotechnology vaccine is area interest now therefore, we have summarized recent developments nanovaccine. article provides comprehensive review available treatment for also nanovaccine usages especially non-small cell lung colon cancer, emphasizing on their development, mechanisms action, diverse range health applications. highlights different types nanocarriers, such as protein-based carriers, liposomes, polymers, exosomes, which in-turn act deliver tumor antigens, adjuvants, or immunomodulatory agents directly targeted sites effectiveness improving immunotherapy. promising innovations technology, viz. , immunotherapeutic nanovaccines, stimulator interferon genes agonist-based vaccines, nanogel supporting photo thermal therapy been addressed detail. summarizes importance biocompatibility specificity criterion minimizing adverse effects by including global impact nanovaccines reducing recurrence.

Language: Английский

---

Development and Assessment of Polyacrylamide-Starch Hydrogel Nanocomposites with Graphene Quantum Dots for Targeted Quercetin Delivery to Brain Tumors

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100848 - 100848

Published: May 1, 2025

Language: Английский

---

Synthesis and performance evaluation of a nanocomposite comprising polyacrylamide hydrogel reinforced with pectin and titanium dioxide for the delivery of curcumin

Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100854 - 100854

Published: May 1, 2025

Language: Английский

---

Synthesis and Characterization of pH-Responsive Sodium Alginate/Zein/γ- Alumina Nanocarriers for Targeted Curcumin Delivery in Lung Cancer

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 8, 2024

Stimulus-responsive drug delivery systems based on anticancer of curcumin constitute a promising strategy to overcome some challenges Lung cancer treatment. In the present study, pH-responsive nanocarriers were designed by sodium alginate (SA), zein, and γ-alumina (γ-Al₂O₃) as nanocarrier via W/O/W double emulsion technique facilitate targeted lung cells. The characterize physical interactions crystalline structure confirmed FTIR XRD, respectively. size drug-loaded nanocomposites was 218.6 nm with monodisperse particle distribution, having rod-like shape approved DLS analysis FE-SEM, Sensitivity samples pH studied using ultraviolet − visible spectroscopy. UV vis spectroscopy results display higher absorption intensities in acidic tumor conditions (pH 5.4) than physiological (7.4). method significantly enhanced loading entrapment efficiency compared other reported systems. Cytotoxicity cell death further analyzed MTT flow cytometry assays. These suggest that SA/zein/γ-Al2O3 nanocomposite is promise system for therapy.

Language: Английский

---