Comments on Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 44
Published: July 27, 2024
Thiophene,
a
heterocyclic
compound
characterized
by
five-membered
ring
comprising
four
carbon
atoms
and
one
sulfur
atom,
has
garnered
significant
attention
in
recent
research
due
to
its
versatile
applications
medicinal
chemosensing
fields.
Thiophene
derivatives
formed
complexes
with
various
transition
metals.
These
exhibit
promising
anti-inflammatory,
anticancer,
antibacterial,
antifungal
other
biological
properties.
Certainly,
the
complexation
phenomenon
involving
thiophene
can
be
effectively
used
for
recognition
of
cations.
Thiophene-based
compounds
act
as
selective
ligands,
forming
stable
specific
heavy
metal
ions.
This
property
implications
environmental
monitoring,
industrial
safety,
public
health,
presence
ions
beyond
permissible
levels
lead
detrimental
effects.
paper
explored
derivatives,
investigating
their
potential
determination
covering
period
from
2018
2024.
serve
ligands
fluorescence
colorimetric
changes
detection
Additionally,
this
study
also
explores
anticancer
efficacy
demonstrated
derived
thiophene,
emphasis
on
those
platinum-group
metals
(Ir(III),
Ru(II),
Ru(III),
Rh,
Os(II),
Os(IV),
Pd(II),
Pt(II)).
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(12), P. e33150 - e33150
Published: June 1, 2024
In
the
previous
study,
synthesis
and
characterization
of
4-(3-fluorophenyl)-3-thiosemicarbazide
benzaldehyde
derivatives
based
thiosemicarbazone
ligands
their
Co(II),
Ni(II),
Cu(II),
Zn(II)
complexes
were
carried
out
to
evaluate
malarial
oxidant
inflammatory
inhibition
abilities,
demonstrating
that
these
compounds
have
robust
efficacy
for
ailments.
present
research,
find
a
combating
agent
against
breast
cancer,
tuberculosis,
bacterial
fungal
ailments,
tested
through
MTT,
microplate
alamar
blue
serial
dilution
protocols.
ADMET
DFT
investigation
analyzed
highly
bioactive
(2,
7–10)
give
new
insight
about
compound's
reactivity,
stability
drug
likeness
properties.
Furthermore,
activity
results
shows
ligand
(2)
its
demonstrate
greater
compared
(1)
complexes.
The
Cu(II)
(9)
(10)
observed
as
efficient
cancer
(MCF-7
cell
line),
TB
(H37Rv
strain),
ailments
in
comparison
standard
drugs
with
0.029
±
0.001
μM
IC50
value
anticancer
0.0034
0.0017
μmol/mL
MIC
anti-tuberculosis
activity.
molecular
docking
investigation,
various
kind
binding
interactions
lowest
affinity
(against
4RJ3
(−10.0
kcal/mol),
2VCJ
(−7.9
kcal/mol))
(−7.8
−8.3
kcal/mol
5V3Y
3PTY
protein)
support
bioactivity.
This
research
highlights
pharmaceutical
importance
transition
metal
having
thiosemicarbazones,
presenting
significant
approach
discovery
potent
anti-infectious
agent.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
21(11)
Published: July 23, 2024
Abstract
In
the
chronicles
of
human
history,
infectious
diseases
played
a
pivotal
role,
influencing
societies,
steering
advancements
in
medicine,
and
significantly
impacting
well‐being
people
worldwide.
Consequently,
pursuit
identifying
effective
combating
agents
for
ailments,
Co(II),
Ni(II),
Cu(II),
Zn(II)
complexes
N′‐(4‐nitrobenzylidene)benzohydrazide
were
synthesized
current
investigation.
Numerous
spectral
physical
analysis
conducted
to
characterize
compounds
which
revealed
octahedral
stereochemistry
complexes.
The
anti‐tuberculosis,
anti‐inflammatory,
antibacterial
antifungal
investigations
demonstrated
that
(1–5)
have
significant
efficacy
these
ailments.
[Zn(L)
2
(H
O)
]
complex
(5)
has
comparable
TB
inhibition
potency
streptomycin
as
shown
by
MIC
value
0.0196±0.0003
μmol/mL.
Additionally,
studies
also
inhibiting
property
standard
drugs
with
IC
50
(07.49±0.08
μM)
(0.0098
μmol/mL)
values.
Furthermore,
pharmacophore
modeling
addition
molecular
docking,
DFT,
MESP,
ADMET
employed
against
give
new
insight
biological
evaluations.
suggested
distinctive
pharmacophoric
features
including
cationic
sites,
hydrogen‐bond
donors
acceptors
provide
valuable
insights
into
rational
drug
design
specific
pharmacological
applications.
Moreover,
another
silico
authenticate
bioactivity
through
substantial
binding
affinities,
energy,
stability,
hardness,
electrophilicity
etc.
Overall,
combined
computational
experimental
results
highlight
potential
promising
candidate
tuberculosis
treatment,
meriting
further
vivo
investigations.
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 31, 2024
ABSTRACT
2‐Aminophenol‐based
Schiff
bases
and
their
metal
complexes
have
drawn
a
lot
of
interest
because
wide
range
biological
activity
uses
in
several
fields.
These
are
synthesized
through
the
condensation
2‐aminophenol
various
carbonyl
compounds,
formed
easily
by
coordinating
with
transition
ions
possess
intriguing
properties
that
rendered
them
promising
candidates
biomedical
research.
compounds
diverse
array
captivating
including
antibacterial,
antifungal,
anticancer,
antioxidant
actions.
Their
versatile
nature
potential
for
tailored
modifications
hold
promise
innovative
applications.
Compared
to
standard
antibiotics
other
studied
C2
,
C8
–
C11
C116
complexes,
along
L16
L17
ligands,
exhibit
highest
antibacterial
activity,
while
C3
C115
demonstrate
antifungal
activity.
The
chelate
formation
ligands
enhanced
antimicrobial
increasing
lipophilic
nature.
C66
C76
C112
L39
ligand
showed
higher
anticancer
than
drugs.
due
improved
permeability
cellular
uptake.
is
related
substituents
base
ligands.
In
containing
an
electron‐withdrawing
group
(e.g.,
Cl
or
Br
NO
2
),
obviously
better
others.
Ligands
L1
L3
L5
L6
L32
demonstrated
most
potent
surpassing
both
conventional
antioxidants.
greater
capability
donating
free
protons
scavenge
radicals.
More
study
needed
fully
explore
2‐aminophenol‐based
development
new
This
review
summarizes
different
synthetic
methods,
activities,
structure–activity
relationship.
aims
conduct
further
research
on
complexes.
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Jan. 12, 2025
ABSTRACT
Four
ortho‐hydroxy
aromatic
bidentate
Schiff
bases
were
synthesized
along
with
the
corresponding
copper
(II)
complexes
and
characterized
by
various
analytical
methods.
The
spatial
configurations
of
metal
suggested
in
light
results
obtained.
Antibacterial
evaluations
revealed
that
ligands
more
active
than
their
Cu(II)
complexes.
study
antifungal
activity
showed
fungus
Candida
albicans
was
inhibited
(HL
3
HL
4
)
(IZ
=
25
mm).
According
to
evaluation
antioxidant
potency
DPPH
method,
only
ligand
demonstrated
a
comparatively
low
ability
scavenge
free
radicals
compared
ascorbic
acid
reference.
Using
AutoDock
4.2
program,
molecular
docking
investigations
conducted
aim
predicting
structure–activity
relationship
for
antibacterial
qualities.
sites
receptor
proteins,
evaluated
assays.
A
good
correlation
found
between
experimental
data.
Applied Organometallic Chemistry,
Journal Year:
2025,
Volume and Issue:
39(2)
Published: Jan. 19, 2025
ABSTRACT
In
the
search
of
antiplasmodium
agents,
hydrazone
ligands,
that
is,
(2‐hydroxy‐5‐nitrobenzylidene)benzo[b]thiophene‐2‐carbohydrazone
(H
2
L
1
)
/(3,5‐dichloro‐2‐hydroxybenzylidene)benzo[b]thiophene‐2‐carbohydrazone
and
their
Co(II),
Ni(II),
Cu(II),
Zn(II)
metal
complexes
were
synthesized.
All
compounds
well
characterized
by
wide
range
spectral
physical
techniques,
FT‐IR,
H
NMR,
13
C
ESR,
mass
spectrometry,
UV‐Vis,
XRD,
SEM‐EDAX,
molecular
conductivity,
thermal
studies
(TG‐DTA).
The
coordination
O‐phenolic,
O‐enolic,
N‐azomethine
donor
atoms
three
aqua
ligands
to
metal(II)
ions
was
confirmed
various
physicochemical
affirming
octahedral
geometry
complexes.
Biological
evaluation
synthesized
involved
assessing
potency
utilizing
microassay
antimicrobial
activities
using
serial
dilution
technique.
Cu(II)
(
5
,
6
9
10
significantly
inhibited
growth
parasitic
ailments
caused
Plasmodium
falciparum
3D7
strain
also
exhibited
remarkable
effectiveness
against
diseases
microbes
comparable
with
standard
drugs
(ciprofloxacin
fluconazole).
Moreover,
theoretical
study
including
docking
employed
3,5‐dihydroxy‐2‐naphthoic
acid
PDB:1U5A
P.
protein
receptor
validate
most
potent
ligand
3
–
).
This
analysis
indicated
docked
could
serve
as
a
promising
drug
candidate
for
malaria.
whereas
ADMET
profiling
authenticated
drug‐like
features
.
Thus,
this
research
provides
fresh
perspectives
in
vivo
minor
developments.
