Comments on Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 44
Published: July 27, 2024
Thiophene,
a
heterocyclic
compound
characterized
by
five-membered
ring
comprising
four
carbon
atoms
and
one
sulfur
atom,
has
garnered
significant
attention
in
recent
research
due
to
its
versatile
applications
medicinal
chemosensing
fields.
Thiophene
derivatives
formed
complexes
with
various
transition
metals.
These
exhibit
promising
anti-inflammatory,
anticancer,
antibacterial,
antifungal
other
biological
properties.
Certainly,
the
complexation
phenomenon
involving
thiophene
can
be
effectively
used
for
recognition
of
cations.
Thiophene-based
compounds
act
as
selective
ligands,
forming
stable
specific
heavy
metal
ions.
This
property
implications
environmental
monitoring,
industrial
safety,
public
health,
presence
ions
beyond
permissible
levels
lead
detrimental
effects.
paper
explored
derivatives,
investigating
their
potential
determination
covering
period
from
2018
2024.
serve
ligands
fluorescence
colorimetric
changes
detection
Additionally,
this
study
also
explores
anticancer
efficacy
demonstrated
derived
thiophene,
emphasis
on
those
platinum-group
metals
(Ir(III),
Ru(II),
Ru(III),
Rh,
Os(II),
Os(IV),
Pd(II),
Pt(II)).
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(11)
Published: Aug. 12, 2024
ABSTRACT
In
recent
times,
there
has
been
a
growing
exploration
of
transition
metal
complexes
as
potential
solutions
for
significant
health
challenges,
including
tuberculosis,
microbes
infection,
and
inflammation.
Therefore,
in
our
ongoing
effort
to
identify
biologically
effective
agents,
Co(II),
Ni(II),
Cu(II),
Zn(II)
H
2
L
1
–H
hydrazone
ligands
were
synthesized.
The
structural
features
synthesized
compounds
recognized
by
employing
several
techniques
such
FT‐IR,
NMR,
13
C
powder
x‐ray
diffraction
(XRD),
UV‐Vis,
ESR,
TG‐DTA,
mass
spectrometry,
molar
conductance
measurements.
bonding
via
O
phenolic
,
enolic
N
azomethine
donor
atoms
the
attachment
three
water
molecules
with
ion
form
octahedral
structure
corroborated
different
spectroscopic
techniques.
anti‐tuberculosis,
antimicrobial,
anti‐inflammatory
activities
assessed
using
microplate
alamar
blue
assay,
serial
dilution,
bovine
serum
albumin
(BSA)
methods,
respectively,
highlighted
more
potency
than
ligands.
Cu(II)
(9
)
(
10
exhibited
excellent
ability
inhibit
growth
37
R
v
strain
Mycobacterium
tuberculosis
comparison
standard
drug
streptomycin.
6
9
showed
superb
antimicrobial
whereas
5
ability.
vitro
findings
on
antituberculosis
activity
reinforced
molecular
docking
study,
which
become
crucial
component
computational
research
utilizing
enzyme
Mtb
Pks13
thioesterase
domain
M.
.
Additionally,
this
work,
absorption–distribution–metabolism–excretion–toxicity
(ADMET)
study
sparked
compounds'
drug‐like
behavior.
Future Medicinal Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 19
Published: Sept. 19, 2024
In
the
annals
of
human
history,
infectious
diseases
significantly
influencing
collective
well-being
people
worldwide.
Consequently,
to
identify
effective
agents
for
ailments,
octahedral
Co(II),
Ni(II),
Cu(II),
Zn(II)
complexes
4-(3-methoxyphenyl)pyrimidin-2-amine
and
2-methoxy-1-napthaldehyde
based
ligand
were
synthesized
well
characterized
in
current
investigation.
Comments on Inorganic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 44
Published: July 27, 2024
Thiophene,
a
heterocyclic
compound
characterized
by
five-membered
ring
comprising
four
carbon
atoms
and
one
sulfur
atom,
has
garnered
significant
attention
in
recent
research
due
to
its
versatile
applications
medicinal
chemosensing
fields.
Thiophene
derivatives
formed
complexes
with
various
transition
metals.
These
exhibit
promising
anti-inflammatory,
anticancer,
antibacterial,
antifungal
other
biological
properties.
Certainly,
the
complexation
phenomenon
involving
thiophene
can
be
effectively
used
for
recognition
of
cations.
Thiophene-based
compounds
act
as
selective
ligands,
forming
stable
specific
heavy
metal
ions.
This
property
implications
environmental
monitoring,
industrial
safety,
public
health,
presence
ions
beyond
permissible
levels
lead
detrimental
effects.
paper
explored
derivatives,
investigating
their
potential
determination
covering
period
from
2018
2024.
serve
ligands
fluorescence
colorimetric
changes
detection
Additionally,
this
study
also
explores
anticancer
efficacy
demonstrated
derived
thiophene,
emphasis
on
those
platinum-group
metals
(Ir(III),
Ru(II),
Ru(III),
Rh,
Os(II),
Os(IV),
Pd(II),
Pt(II)).
