Nanoparticle-Encapsulated Plant Polyphenols and Flavonoids as an Enhanced Delivery System for Anti-Acne Therapy

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 209 - 209

Published: Feb. 4, 2025

This study conducted a literature review by searching for articles related to the treatment of skin infections/wrinkles using nano-delivery systems containing natural compounds. The search was in various databases published last 10 years, with strict inclusion and exclusion criteria. Of 490 found, 40 were considered relevant. Acne vulgaris is common dermatological disorder characterised inflammation sebaceous glands, often resulting development pimples, cysts, scarring. Conventional treatments, including antibiotics topical retinoids, frequently demonstrate limitations such as side effects, resistance, insufficient absorption. Recent advancements nanotechnology have enabled creation innovative drug-delivery that enhance effectiveness reduce adverse effects anti-acne medications. Polyphenols flavonoids, bioactive compounds notable anti-inflammatory, antioxidant, antibacterial properties, are recognised their therapeutic acne treatment. However, practical application hindered solubility, stability, bioavailability. incorporation these into nanoparticle-based delivery has shown promise resolving challenges. Various nanoparticle platforms, lipid-based nanoparticles, polymeric solid lipid evaluated ability improve controlled release, targeted polyphenols flavonoids skin. advent polyphenol flavonoid-loaded nanoparticles marks new therapy era.

Language: Английский

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Green biosynthesis of titanium dioxide nanoparticles incorporated gellan gum hydrogel for biomedical application as wound dressing

Frontiers in Chemistry, Journal Year: 2025, Volume and Issue: 13

Published: April 17, 2025

Titanium dioxide nanoparticles (TiO2NPs) are widely synthesized chemically for industrial applications. However, these methods often have negative environmental impacts, rendering them unsuitable biomedical Green synthesis approaches offer a promising alternative due to their simplicity, friendliness, and cost-effectiveness. In this study, we report the biosynthesis of TiO2NPs using Morus alba leaf extract subsequent incorporation into gellan gum (GG) biopolymer create hydrogel. The physicochemical properties biosynthesized TiO2NP@GG hydrogel were characterized Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive (EDS), photoelectron (XPS). Furthermore, bioactivity materials was investigated through antibacterial assays against Staphylococcus aureus Escherichia coli, as well in vitro wound healing studies 3T3 fibroblast scratch assay. XRD analysis confirmed successful formation anatase phase TiO2. SEM images revealed presence irregular rod-shaped TiO2 nanoparticles, with EDS confirming composition oxygen titanium. particle size determined be 80-90 nm, exhibited homogeneous distribution throughout network. displayed significant activity both S. E. coli. assay on cells seeded onto demonstrated high cell survival rate enhanced migration, suggesting potential applications dressing material.

Language: Английский

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Green synthesis of silica nanoparticles using Enhalus acoroides: characterization and antioxidant activity

Biomass Conversion and Biorefinery, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 6, 2025

Language: Английский

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De Novo synthesis of selenium-doped CeO2@Fe3O4 nanoparticles for improving secondary metabolite biosynthesis in Carthamus tinctorius cell suspension culture

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159705 - 159705

Published: Jan. 1, 2025

Language: Английский

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Trends in plant tissue culture, production, and secondary metabolites enhancement of medicinal plants: a case study of thyme

Planta, Journal Year: 2025, Volume and Issue: 261(4)

Published: March 10, 2025

Language: Английский

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Mini-review: Application of nanoparticles in plant biotechnology and agriculture

In Vitro Cellular & Developmental Biology - Plant, Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Language: Английский

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Biosynthesized sulfur nanoparticles: a novel strategy to enhance antioxidant secondary metabolites in Lotus arabicus L. callus cultures

BMC Plant Biology, Journal Year: 2025, Volume and Issue: 25(1)

Published: May 7, 2025

Abstract Background Secondary metabolites are distinct compounds with significant medicinal value, yet their production and chemical synthesis present considerable challenges. This necessitates the development of innovative strategies to improve yield. study investigated potential biosynthesized sulfur nanoparticles (SNPs) as an eco-friendly elicitor enhance antioxidant secondary in Lotus arabicus L. callus cultures. Results After seven weeks, induced calli L were transferred MS media supplemented SNPs at different concentrations (0, 25, 50, 100, 200 mg/l). The results indicated that (100 mg/l) significantly higher profiles for biomass metabolite compared control treatments. Enzyme activities related biosynthesis, specifically phenylalanine ammonia lyase (PAL) polyphenol oxidase (PPO) enhanced a dose-dependent manner, greatest increases observed 100 mg/l SNPs. also modulated oxidative stress markers (MDA H 2 O ), generally improving growth conditions by reducing stress, except highest concentration mg/l. Additionally, application markedly upregulated expression levels six crucial genes biosynthesis pathway ( chalcone synthase CHS), PAL), flavonol FLS), isomerase CHI) , hydroxycinnamoyl CoA quinate transferase (HQT) deoxyxylulose phosphate reductoisomerase DXR )). Quantitative HPLC profiling 16 phenolic flavonoid revealed supplementation resulted noticeable boots majority measured SNP supplementation. Conclusion Overall, culture positively influenced molecular physiological levels, increasing its use.

Language: Английский

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Eco-friendly synthesis of gold nanoparticles using Ruta graveolens Leaf extract and their efficient catalytic reduction of 4-Nitroaniline, Methylene Blue and Antibiotic Nitrofurantoin

Journal of Organometallic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 123706 - 123706

Published: May 1, 2025

Language: Английский

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The combination of nanoparticles and endophytes boosts Thyme (Thymus vulgaris L.) resistance to drought stress by elevating levels of phenolic compounds, flavonoids, and essential oils

Chemical and Biological Technologies in Agriculture, Journal Year: 2024, Volume and Issue: 11(1)

Published: Nov. 7, 2024

As climate change and water scarcity increasingly threaten agricultural productivity, enhancing plant resilience to drought has attracted great attention. This study explored the potential of combining Fe2O3 nanoparticles (FeNPs), endophytic bacteria (EB), fungi (EF) boost tolerance in Thymus vulgaris. The research aimed assess how these combined treatments affect plant's physiological responses chemical composition under stress. A factorial experiment was designed using completely randomized design (CRD) method, incorporating four irrigation levels [100%, 75%, 50%, 25% field capacity (FC)], FeNPs concentrations (0, 0.5, 1, 1.5 mg L−1), three endophyte types (control, bacteria, fungi). After extracting, purifying, identifying, screening EB EF from nine Lamiaceae species, endophytes Azospirillum lipoferum Aspergillus oryzae isolated Salvia mirzayanii exhibited highest resistance. amounts TFM (45.45 g) TDM (21.56 were obtained combination at 1 L−1 with 100% FC. At FC, treatment increased activities polyphenol oxidase (PPO) phenylalanine ammonia-lyase (PAL) by 62.12% 18.23% compared control, respectively. In addition, optimal humidity conditions, FeNP higher than 0.5 leading a decrease PPO activity. content total phenols observed 37.5% increase FeNPs, while flavonoids showed 62.72% mg/L FeNPs. level p-coumaric acid (34.27% control). (1 L−1) caffeic thyme plants 24.70% 10.08%, inoculation (11.9%) ferulic application as foliar spray decreased plants. essential oil percentage FC after (0.5 resulting significant increases 14.7% 82.12%, respectively, control. led an decreasing dominant compounds, thymol, carvacrol. thymol carvacrol not affected interaction effects stress, endophytes, (1.5 caused 17.44% 29.87% control amount 13.75% 31.01% All acid, PPO; particles act abiotic stressors sub-toxic become phytotoxic concentrations. It seems that promise T. These have significantly contributed production enzymatic antioxidants, flavonoids, phenolic reduction oxidants. same time, they improved both quality quantity oils. highlights importance establishing effective antioxidant system response environmental stresses.

Language: Английский

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Bacopa monnieri (L.) Wettst. plant extract mediated synthesis of metallic nanoparticles and regulation of bacoside-A- memory enhancer compound and their application: A comprehensive review

Plant Nano Biology, Journal Year: 2024, Volume and Issue: unknown, P. 100133 - 100133

Published: Dec. 1, 2024

Language: Английский

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