Early Detection and Monitoring of Nephrolithiasis: The Potential of Electrochemical Sensors DOI Creative Commons
Kaiqiang Sun,

Ningbin Zhao,

Peizheng Shi

et al.

Sensors, Journal Year: 2025, Volume and Issue: 25(8), P. 2547 - 2547

Published: April 17, 2025

Nephrolithiasis (kidney stone disease) continues to pose a significant global health challenge, affecting millions of individuals and placing substantial economic pressures on healthcare systems. Traditional diagnostic methods—such as computed tomography (CT), ultrasound, basic urinalysis—are often limited by issues including radiation exposure, lower sensitivity in detecting small stones, operator dependency, the inability provide real-time analysis. In response, electrochemical sensors have emerged innovative powerful tools capable rapid, sensitive, specific detection key biomarkers associated with nephrolithiasis. This review highlights advances approaches for monitoring oxalate uric acid, two primary metabolites implicated kidney formation. We discuss principles electrode design fabrication, nanomaterial integration, 3D printing, molecular imprinting, which markedly improved limits selectivity. Furthermore, we critically evaluate practical challenges—such sensor fouling, reproducibility, stability complex biological matrices—that currently impede widespread clinical implementation. The potentials miniaturization point-of-care integration are emphasized, an eye toward continuous or home-based systems that can offer personalized insights into risk formation progression. By consolidating recent findings exploring future trends multi-analyte wearable diagnostics, this provides roadmap translating from research laboratories routine practice, ultimately aiming enhance early intervention improve patient outcomes

Language: Английский

An Electrochemical Nickel–Cobalt (Ni–Co)/Graphene Oxide-Polyvinyl Alcohol (GO-PVA) Sensor for Glucose Detection DOI Creative Commons
Shu‐Hui Yeh,

Yaw‐Jen Chang,

Chun-Yi Hsieh

et al.

Sensors, Journal Year: 2025, Volume and Issue: 25(7), P. 2050 - 2050

Published: March 25, 2025

This paper presents a non-enzymatic sensor for glucose detection in an environment where and insulin coexist. The is based on three-electrode chip fabricated by etching the copper foil of printed circuit board. working electrode coated with graphene oxide-polyvinyl alcohol composite film, followed electroplating nickel-cobalt layer additional surface treatment using O2 plasma. experimental results indicate that within concentration 2 mM to 10 0.1 1 mM, measured current exhibits linear relationship or insulin, regardless whether cyclic voltammetry sweep used. However, limit 0.01 ensuring remains unaffected interference. In this sensor, serves as catalyst detection, while enhances sensing performance.

Language: Английский

Citations

0
Ultrasensitive electrochemical sensor for monitoring uric acid in sweat based on hexagonally-structured Co2CrMnFeNi high-entropy alloy nanosheets with exceptional catalytic performance DOI
Qingqing Zhang, Li Ruiyi, Yongqiang Yang

et al.

Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137790 - 137790

Published: April 1, 2025

Language: Английский

Citations

0
Early Detection and Monitoring of Nephrolithiasis: The Potential of Electrochemical Sensors DOI Creative Commons
Kaiqiang Sun,

Ningbin Zhao,

Peizheng Shi

et al.

Sensors, Journal Year: 2025, Volume and Issue: 25(8), P. 2547 - 2547

Published: April 17, 2025

Nephrolithiasis (kidney stone disease) continues to pose a significant global health challenge, affecting millions of individuals and placing substantial economic pressures on healthcare systems. Traditional diagnostic methods—such as computed tomography (CT), ultrasound, basic urinalysis—are often limited by issues including radiation exposure, lower sensitivity in detecting small stones, operator dependency, the inability provide real-time analysis. In response, electrochemical sensors have emerged innovative powerful tools capable rapid, sensitive, specific detection key biomarkers associated with nephrolithiasis. This review highlights advances approaches for monitoring oxalate uric acid, two primary metabolites implicated kidney formation. We discuss principles electrode design fabrication, nanomaterial integration, 3D printing, molecular imprinting, which markedly improved limits selectivity. Furthermore, we critically evaluate practical challenges—such sensor fouling, reproducibility, stability complex biological matrices—that currently impede widespread clinical implementation. The potentials miniaturization point-of-care integration are emphasized, an eye toward continuous or home-based systems that can offer personalized insights into risk formation progression. By consolidating recent findings exploring future trends multi-analyte wearable diagnostics, this provides roadmap translating from research laboratories routine practice, ultimately aiming enhance early intervention improve patient outcomes

Language: Английский

Citations

0