Emerging Roles of Growth Differentiation Factor 15 in Immunoregulation and Pathogenesis

The Journal of Immunology, Journal Year: 2023, Volume and Issue: 210(1), P. 5 - 11

Published: Jan. 1, 2023

Abstract Growth differentiation factor 15 (GDF-15) is a cytokine that widely used as biomarker for the severity of diverse disease states. It also has been shown to play protective role after tissue injury and promote negative energy balance during obesity diabetes. In addition its metabolic effects, GDF-15 regulates host’s immune responses infectious noninfectious diseases. can suppress type 1 and, in contrast, 2 inflammatory response. this brief review, we discuss how affects effector function recruitment cells, pathways induce expression, mechanisms by which it regulated inflammation infection. We further highlight outstanding questions should be focus future investigations emerging field.

Language: Английский

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Protective role of the novel cytokine Metrnl/ interleukin-41 in host immunity defense during sepsis by promoting macrophage recruitment and modulating Treg/Th17 immune cell balance

Clinical Immunology, Journal Year: 2023, Volume and Issue: 254, P. 109690 - 109690

Published: July 7, 2023

Language: Английский

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Inflammatory mechanisms and intervention strategies for sepsis‐induced myocardial dysfunction

Immunity Inflammation and Disease, Journal Year: 2023, Volume and Issue: 11(5)

Published: May 1, 2023

Sepsis-induced myocardial dysfunction (SIMD) is the leading cause of death in patients with sepsis intensive care units. The main manifestations SIMD are systolic and diastolic dysfunctions myocardium. Despite our initial understanding over past three decades, incidence mortality remain high. This may be attributed to large degree heterogeneity among initiating factors, disease processes, host states involved SIMD. Previously, organ caused by was thought an impairment brought about excessive inflammatory response. However, many recent studies have shown that a consequence combination factors shaped responses between pathogen host. In this article, we review mechanisms potential novel therapeutic strategies

Language: Английский

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Role of PFKFB3-driven glycolysis in sepsis

Annals of Medicine, Journal Year: 2023, Volume and Issue: 55(1), P. 1278 - 1289

Published: May 18, 2023

Sepsis is still the leading cause of death as a result infection. Metabolic disorder plays vital role in sepsis progression. Glycolysis intensification most characteristic feature sepsis-related metabolic disorders. The enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) critical engine that controls rate glycolysis. Recent studies have revealed accelerates PFKFB3-driven glycolysis different cells, including macrophages, neutrophils, endothelial cells and lung fibroblasts. Furthermore, increased PFKFB3 closely related to excessive inflammatory response high mortality sepsis. Interestingly, inhibition alone or combination has also shown great potential treatment Therefore, an improved understanding canonical noncanonical functions may provide novel combinatorial therapeutic target for This review summarizes regulation immunocyte activation nonimmune cell damage In addition, we present recent achievements development drugs discuss their roles sepsis.KEY MESSAGESepsis induces expression immunocytes thereby enhancing cellular glycolytic flux.PFKFB3-driven reprogramming sepsis.Inhibition provides

Language: Английский

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Single-cell RNA sequencing deciphers the mechanism of sepsis-induced liver injury and the therapeutic effects of artesunate

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 44(9), P. 1801 - 1814

Published: April 11, 2023

Language: Английский

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