Psychiatry Research,
Journal Year:
2024,
Volume and Issue:
339, P. 116063 - 116063
Published: July 6, 2024
The
object
of
this
study
is
test
whether
mitochondrial
blood-based
biomarkers
are
associated
with
markers
metabolic
syndrome
in
bipolar
disorder,
hypothesizing
higher
lactate
but
unchanged
cell-free
circulating
DNA
levels
disorder
patients
syndrome.
In
a
cohort
study,
primary
testing
from
the
FondaMental
Advanced
Centers
Expertise
for
(FACE-BD)
was
conducted,
including
837
stable
patients.
I-GIVE
validation
consists
237
participants:
and
acute
patients,
non-psychiatric
controls,
schizophrenia
Multivariable
regression
analyses
show
significant
association
triglycerides,
fasting
glucose
systolic
diastolic
blood
pressure.
Significantly
were
presence
after
adjusting
potential
confounding
factors.
Mitochondrial-targeted
metabolomics
identified
distinct
metabolite
profiles
syndrome,
differing
those
without
changes
Circulating
not
This
thorough
analysis
indicate
associations
while
showing
metabolites
can
further
stratify
BD.
relevant
to
improve
identification
stratification
provide
personalized-therapeutic
opportunities.
Antioxidants and Redox Signaling,
Journal Year:
2023,
Volume and Issue:
39(4-6), P. 278 - 320
Published: Jan. 15, 2023
Significance:
Type
2
diabetes
mellitus,
which
is
related
to
oxidative
stress
and
mitochondrial
dysfunction,
one
of
the
most
prevalent
diseases
in
world.
In
past
decade,
alterations
autophagy
have
been
shown
play
a
fundamental
role
development
control
type
diabetes.
Further,
mitophagy
has
recognized
as
key
player
eliminating
dysfunctional
mitochondria
this
disease.
Recent
Advances:
Recently,
much
progress
made
understanding
molecular
events
associated
with
stress,
Critical
Issues:
Despite
increasing
evidence
relationship
between
their
pathophysiolology
diabetes,
effective
therapeutic
strategies
combat
disease
through
targeting
mitochondria,
autophagy,
are
yet
be
implemented.
Future
Directions:
This
review
provides
wide
perspective
existing
literature
concerning
complicated
interplay
mitophagy,
dysfunction
potential
targets
based
on
these
mechanisms
explored.
Antioxid.
Redox
Signal.
39,
278-320.
Journal of Translational Medicine,
Journal Year:
2023,
Volume and Issue:
21(1)
Published: Oct. 26, 2023
Abstract
Liver
steatosis,
inflammation,
and
variable
degrees
of
fibrosis
are
the
pathological
manifestations
nonalcoholic
steatohepatitis
(NASH),
an
aggressive
presentation
most
prevalent
chronic
liver
disease
in
Western
world
known
as
fatty
(NAFL).
Mitochondrial
hepatocyte
dysfunction
is
a
primary
event
that
triggers
affecting
Kupffer
hepatic
stellate
cell
behaviour.
Here,
we
consider
role
impaired
mitochondrial
function
caused
by
lipotoxicity
during
oxidative
stress
hepatocytes.
Dysfunction
phosphorylation
ROS
production
cause
release
damage-associated
molecular
patterns
from
dying
hepatocytes,
leading
to
activation
innate
immunity
trans-differentiation
cells,
thereby
driving
NASH.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: July 26, 2024
Allergic
diseases
like
asthma,
allergic
rhinitis
and
dermatitis
pose
a
significant
global
health
burden,
driving
the
search
for
novel
therapies.
The
NLRP3
inflammasome,
key
component
of
innate
immune
system,
is
implicated
in
various
inflammatory
diseases.
Upon
exposure
to
allergens,
undergoes
two-step
activation
process
(priming
assembly)
form
active
inflammasomes.
These
inflammasomes
trigger
caspase-1
activation,
leading
cleavage
pro-inflammatory
cytokines
(IL-1β
IL-18)
GSDMD.
This
induces
pyroptosis
amplifies
inflammation.
Recent
studies
humans
mice
strongly
suggest
link
between
IL-1β,
IL-18,
development
However,
further
research
needed
fully
understand
NLRP3's
specific
mechanisms
allergies.
review
aims
summarize
latest
advances
regulation.
We
will
discuss
small
molecule
drugs
natural
products
targeting
as
potential
therapeutic
strategies
Frontiers in Immunology,
Journal Year:
2023,
Volume and Issue:
14
Published: July 20, 2023
Inflammasomes
are
multiprotein
signaling
platforms
in
the
cytosol
that
senses
exogenous
and
endogenous
danger
signals
respond
with
maturation
secretion
of
IL-1β
IL-18
pyroptosis
to
induce
inflammation
protect
host.
The
inflammasome
best
studied
is
Nucleotide-binding
oligomerization
domain,
leucine-rich
repeat-containing
family
pyrin
domain
containing
3
(NLRP3)
inflammasome.
It
activated
a
two-step
process:
priming
activation,
leading
sensor
NLRP3
recruitment
both
adaptor
ASC
executioner
pro-caspase
1,
which
by
cleavage.
Moreover,
activation
regulated
posttranslational
modifications,
including
ubiquitination/deubiquitination,
phosphorylation/dephosphorylation,
acetylation/deacetylation,
SUMOylation
nitrosylation,
interaction
NLPR3
protein
binding
partners.
connection
between
it
metabolism
receiving
increasing
attention
this
field.
In
review,
we
present
structure,
functions,
regulation
NLRP3,
special
emphasis
on
mitochondrial
dysfunction-mtROS
production
metabolic
signals,
i.e.,
metabolites
as
well
enzymes.
By
understanding
specific
inhibitors
can
be
rationally
designed
for
treatment
prevention
various
immune-
or
metabolic-based
diseases.
Lastly,
review
current
their
mechanism
action.
PeerJ,
Journal Year:
2024,
Volume and Issue:
12, P. e16465 - e16465
Published: Jan. 4, 2024
Excessive
induction
of
inflammatory
and
immune
responses
is
widely
considered
as
one
vital
factors
contributing
to
the
pathogenesis
progression
central
nervous
system
(CNS)
diseases.
Neutrophils
are
well-studied
members
cell
family,
innate
adaptive
immunity.
Neutrophil-released
neutrophil
extracellular
traps
(NETs)
play
an
important
role
in
regulation
various
kinds
diseases,
including
CNS
In
this
review,
current
knowledge
on
biological
features
NETs
will
be
introduced.
addition,
several
popular
diseases
cerebral
stroke,
Alzheimer’s
disease,
multiple
sclerosis,
amyotrophic
lateral
sclerosis
(ALS),
neurological
cancers
described
discussed
through
reviewing
previous
related
studies.
Cell Death Discovery,
Journal Year:
2023,
Volume and Issue:
9(1)
Published: July 14, 2023
Abstract
NLRP3
inflammasome
is
a
multiprotein
complex
expressed
in
variety
of
cells
to
stimulate
the
production
inflammatory
factors.
Activation
depends
on
regulatory
mechanism,
and
its
pro-inflammatory
function
plays
an
important
role
pancreatic
diseases.
In
this
literature
review,
we
summarize
activation
mechanism
analyze
each
four
typical
Through
article,
provide
relatively
comprehensive
summary
researchers
field,
some
targeted
therapy
routes.
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
262, P. 115121 - 115121
Published: June 27, 2023
Perfluorooctane
sulfonate
(PFOS)
is
not
readily
degradable
in
the
natural
environment,
and
PFOS
widely
used
industry.
Globally,
exposure
occurs
environment.
persistent
non-biodegradable.
The
general
public
can
come
into
contact
with
by
inhaling
PFOS-contaminated
dust
air,
drinking
contaminated
water,
eating
food.
Thus,
induces
potential
health
damage
globally.
In
this
study,
effect
of
on
aging
liver
was
investigated.
an
vitro
cellular
model,
a
series
biochemical
experiments
were
conducted
via
cell
proliferation
assays,
flow
cytometry,
immunocytochemistry
laser
confocal
microscopy.
It
found
that
led
to
hepatocyte
senescence
Sa-β-gal
staining
detection
markers
(p16,
p21
p53).
addition,
also
oxidative
stress
inflammation.
Mechanistic
studies
have
shown
lead
elevated
mitochondrial
ROS
hepatocytes
through
calcium
overload.
cause
alterations
membrane
potential,
subsequently
inducing
mPTP
(mitochondrial
permeability
transition
pore)
opening,
which
turn
releases
mt-DNA
from
mitochondria
cytoplasm,
thus
activating
NLRP3,
causes
hepatocytes.
Based
this,
we
further
analyzed
vivo
caused
tissues.
On
basis,
preliminarily
investigated
β-carotene
it
could
alleviate
PFOS.
summary,
current
study
shows
liver,
provides
more
in-depth
understanding
toxicity
characteristics
