International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(23), P. 16854 - 16854
Published: Nov. 28, 2023
The
present
review
explores
the
critical
role
of
oxime
and
ether
moieties
in
enhancing
physicochemical
anticancer
properties
structurally
diverse
molecular
frameworks.
Specific
examples
are
carefully
selected
to
illustrate
distinct
contributions
these
functional
groups
general
strategies
for
design,
modulation
biological
activities,
computational
modeling,
structure–activity
relationship
studies.
An
extensive
literature
search
was
conducted
across
three
databases,
including
PubMed,
Google
Scholar,
Scifinder,
enabling
us
create
one
most
comprehensive
overviews
how
oximes
ethers
impact
antitumor
activities
within
a
wide
range
structural
This
focused
on
various
combinations
keywords
or
their
synonyms,
related
activity
ethers,
relationships,
mechanism
action,
as
well
dynamics
docking
Each
article
evaluated
based
its
scientific
merit
depth
study,
resulting
268
cited
references
more
than
336
illustrative
chemical
structures
support
this
analysis.
As
many
previous
reviews
focus
subclass
family
compounds,
report
represents
rare
fully
assessments
potential
group
molecules
scaffolds.
Current Topics in Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
23(12), P. 1104 - 1122
Published: Feb. 1, 2023
Abstract:
Tumor-associated
macrophages
(TAMs)
play
a
pivotal
role
in
the
progression
and
re-sistance
of
tumors
to
different
anticancer
drugs.
TAMs
can
modulate
tumor
microenvironment
(TME)
favor
immune
system
exhaustion.
The
interactions
with
TME
affect
function
cytotoxic
CD8+
T
lymphocytes
(CTLs)
natural
killer
(NK)
cells.
Furthermore,
induce
cancer
cell
proliferation
by
releasing
some
growth
factors,
such
as
transforming
factor
(TGF)-β.
have
several
positive
cross-talks
other
suppressive
cells
regulatory
(Tregs),
myeloid-derived
suppressor
(MDSCs),
cancer-associated
fibroblasts
(CAFs),
cells,
leading
release
prolif-eration
growth.
These
also
invasion
migration
angiogenesis,
metastasis.
inhibition
is
an
intriguing
strategy
for
overcoming
resistance
suppression
Some
natural-derived
agents
melatonin,
curcumin,
resveratrol,
apigenin,
flavonoids
shown
ability
TME,
including
TAMs.
adjuvants
may
be
able
boost
antitumor
immunity
through
modulation
This
review
explains
modulatory
effects
well-known
naturally
derived
on
activity
these
useful
suppressing
invasion.
Clinical and Experimental Pharmacology and Physiology,
Journal Year:
2023,
Volume and Issue:
50(5), P. 353 - 368
Published: Feb. 14, 2023
Immune
reactions
are
involved
in
both
tumour
and
normal
tissue
response
to
therapy.
Elevated
secretion
of
certain
chemokines,
exosomes
cytokines
triggers
inflammation,
pain,
fibrosis
ulceration
among
other
side
effects.
On
the
hand,
tumour-promoting
molecules
suppresses
activity
anticancer
immune
cells
facilitates
proliferation
malignant
cells.
Novel
drugs
such
as
checkpoint
inhibitors
(ICIs)
boost
immunity
via
inducing
natural
killer
(NK)
CD8+
T
lymphocytes.
Certain
chemotherapy
radiotherapy
may
induce
tumour,
however,
have
severe
effects
for
tissues
through
stimulation
several
responses.
Thus,
administration
products
with
low
be
a
promising
approach
modulate
system
organs.
Resveratrol
is
well-known
phenol
diverse
on
tumours.
To
date,
large
number
experiments
confirmed
potential
resveratrol
an
adjuvant.
This
review
focuses
ensuing
or
suppression
responses
after
drugs.
Later
on,
immunoregulatory
following
exposure
agents
will
discussed.
Drug Metabolism Reviews,
Journal Year:
2024,
Volume and Issue:
56(1), P. 62 - 79
Published: Jan. 2, 2024
Melatonin,
historically
recognized
for
its
primary
role
in
regulating
circadian
rhythms,
has
expanded
influence
particularly
due
to
wide
range
of
biological
activities.
It
firmly
established
itself
cancer
research.
To
highlight
versatility,
we
will
delve
into
how
melatonin
interacts
with
key
signaling
pathways,
such
as
the
Wnt/β-Catenin,
PI3K,
and
NF-κB
which
play
foundational
roles
tumor
development
progression.
Notably,
can
intricately
modulate
these
potentially
affecting
various
cellular
functions
apoptosis,
metastasis,
immunity.
Additionally,
a
comprehensive
review
current
clinical
studies
provides
dual
perspective.
These
confirm
melatonin's
potential
management
but
also
underscore
inherent
limitations,
limited
bioavailability,
often
relegates
it
supplementary
treatments.
Despite
this
limitation,
there
is
an
ongoing
quest
innovative
solutions
advancements
include
derivatives
cutting-edge
delivery
systems.
By
synthesizing
past,
present,
future,
detailed
overview
evolving
oncology,
positioning
cornerstone
future
therapeutics.
Current Pharmaceutical Design,
Journal Year:
2023,
Volume and Issue:
29(22), P. 1713 - 1728
Published: April 27, 2023
Cancer
has
remained
to
be
one
of
the
major
challenges
in
medicine
and
regarded
as
second
leading
cause
death
worldwide.
Different
types
cancer
may
resist
anti-cancer
drugs
following
certain
mutations
such
those
tumor
suppressor
genes,
exhaustion
immune
system,
overexpression
drug
resistance
mediators,
which
increase
required
concentration
anticancer
so
overcome
resistance.
Moreover,
treatment
with
a
high
dose
is
highly
associated
severe
normal
tissue
toxicity.
Administration
low-toxic
agents
long
been
an
intriguing
idea
enhance
suppression.
Naturally
occurring
e.g.,
herb-derived
molecules
have
shown
dual
effect
on
malignant
cells.
On
hand,
these
induce
cell
cells,
while
other
hand
reduce
Nobiletin,
well-known
polymethoxyflavones
(PMFs),
reportedly
various
beneficial
effects
suppression
protection
cells
against
different
toxic
agents.
Our
review
aims
explain
main
mechanisms
underlying
nobiletin
inhibitor
cancer.
We
reviewed
caused
by
nobiletin,
stimulation
reactive
oxygen
species
(ROS),
modulation
evasion
mechanisms,
targeting
epigenetic
modulators,
among
others;
inhibitory
affecting
properties
hypoxia,
multidrug
resistance,
angiogenesis,
epithelial-mesenchymal
transition
(EMT)
fully
investigated.
Also,
inhibition
anti-apoptotic
invasive
induced
will
later
discussed.
In
end,
protective
cells/tissue,
clinical
trial
results,
future
perspectives
are
reviewed.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 1919 - 1919
Published: Jan. 18, 2023
The
circadian
clock
is
a
regulatory
system,
with
periodicity
of
approximately
24
h,
that
generates
rhythmic
changes
in
many
physiological
processes.
Increasing
evidence
links
chronodisruption
aberrant
functionality
gene
expression,
resulting
multiple
diseases,
including
cancer.
In
this
context,
tumor
cells
have
an
altered
machinery
compared
to
normal
cells,
which
deregulates
the
cell
cycle,
repair
mechanisms,
energy
metabolism
and
other
Melatonin
main
hormone
produced
by
pineal
gland,
whose
production
secretion
oscillates
accordance
light:dark
cycle.
addition,
melatonin
regulates
expression
genes,
those
cancer
could
play
key
role
numerous
oncostatic
effects
hormone.
This
review
aims
describe
clarify
genes
cancer,
as
well
possible
mechanisms
action
through
it
tumor's
machinery,
order
propose
future
anti-neoplastic
clinical
treatments.
