Arhiv za farmaciju, Journal Year: 2024, Volume and Issue: 74(6), P. 774 - 795
Published: Jan. 1, 2024
Schizophrenia and other related disorders represent a major clinical challenge, with environmental genetic factors contributing to their occurrence. Animal models are indispensable tools for understanding the complex neurobiological mechanisms underlying psychosis developing new therapeutic approaches. This review focuses on animal commonly used in schizophrenia research, especially those based prenatal postnatal risk factors. Prenatal exposure infections, such as bacterial lipopolysaccharides (LPS) viral components poly I:C, activates immune responses that lead long-lasting structural functional changes brain, including hippocampal atrophy cortical thinning. Postnatal early life stress, social isolation drug abuse, particularly cannabis, also being modelled investigate effects brain development onset of psychosis. These allow controlled manipulation challenges provide insights into aetiology pathophysiology disease. However, variability experimental protocols lack female representation many studies underscore need more robust inclusive models. Ultimately, these crucial better testing potential interventions.
Language: Английский