Participation of non-receptor Src family tyrosine kinases in the formation of neutrophil extracellular traps

Vestnik Moskovskogo universiteta Seria 16 Biologia, Journal Year: 2023, Volume and Issue: 78(№1, 2023), P. 11 - 16

Published: April 30, 2023

Neutrophils release decondensed nuclear chromatin or Neutrophil Extracellular Traps (NETs) in response to a great number of physiological and pharmacological stimuli. However, apart from the host defensive function, NETs play an essential role pathogenesis various autoimmune, inflammatory, malignant diseases. Therefore, understanding molecular mechanisms formation, usually leading neutrophil death (NETosis), is important control probable aberrant excessive release. The Src-family kinases (Src-kinases) are non-receptor tyrosine that involved variety human functions. their NETosis oxidative burst has not been sufficiently studied. Since three representatives Src-kinases (Hck, Fgr, Lyn) have described neutrophils, we studied contribution using inhibitory analysis. We shown induced by calcium ionophore A23187 but mimetic diacylglycerol phorbol-12-myristate-13-acetate (PMA).

Language: Английский

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Neutrophils Are Atypical Antigen-Presenting Cells

Moscow University Biological Sciences Bulletin, Journal Year: 2023, Volume and Issue: 78(2), P. 45 - 52

Published: June 1, 2023

Language: Английский

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