Molecular Biotechnology, Journal Year: 2023, Volume and Issue: unknown
Published: Nov. 30, 2023
Language: Английский
Neuroglia, Journal Year: 2025, Volume and Issue: 6(1), P. 12 - 12
Published: March 2, 2025
Background/Objectives: Spinal cord injury (SCI) is a devastating condition that leads to cascade of cellular and molecular events, resulting in both primary secondary damage. Among the many cells involved post-SCI environment, glial spinal brain are pivotal determining trajectory repair. Methods: While recent SCI studies have shown changes genotype following injury, exactly how these alterations occur after damage remains unknown. In this sense, systemic inflammatory molecules could be connection between brain, inducing activation by different signaling pathways. Preclinical nuclear factor-κB (NF-κB), Janus kinase/signal transducer activator transcription (JAK/STAT), phosphoinositide 3-kinase/Akt (PI3K/Akt) pathways change type. Results: These cells, which include astrocytes microglia, exhibit dynamic responses contributing neuroprotection neurodegeneration. effects indicate environment causes type leading actions. Conclusions: Understanding mechanisms cell activation, it possible clarify roles pathophysiology their potential repair post-injury.
Language: Английский
Citations
0
IBRO Neuroscience Reports, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110399 - 110399
Published: March 1, 2025
Language: Английский
Citations
0
Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
Spinal cord injury (SCI) is a serious neurological disease with an extremely high disability rate. Most patients show loss of motor and sensory functions below the level injury. Current treatment protocols are based on early surgical decompression pharmacotherapy. However, efficacy these interventions suboptimal. Due to its complex pathophysiological mechanisms difficulty central nervous system (CNS) regeneration, exploring effective therapeutic remains daunting. Flavonoids secondary metabolites unique plants that have attracted attention in recent years for their potential now commonly used inflammation, tumors, other diseases. For SCI, related studies still exploring; some compounds, such as quercetin, fisetin, hesperetin, shown good anti-inflammatory anti-apoptotic properties, which help restore function injured spinal cord. flavonoids exhibit certain disadvantages, including poor solubility, low bioavailability, inability achieve long-term controlled release. Some proposed drug delivery strategies-including nanoparticles, hydrogels, collagen scaffolds-to enhance efficacy. In this paper, we summarize strategies SCI by searching relevant literature propose future research directions provide new ideas multimodal SCI.
Language: Английский
Citations
0
Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119731 - 119731
Published: April 1, 2025
Language: Английский
Citations
0
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: April 12, 2025
Spinal cord injury (SCI) remains a devastating central nervous system disorder. The complex pathological microenvironment following SCI, particularly the imbalance in neuroinflammation, contributes to its therapeutic challenges. Microglial pyroptosis, type of programmed cell death, is pivotal exacerbating neuroinflammation and secondary tissue damage after SCI. Our previous study demonstrated inhibitory efficacy conditioned medium (CM) derived from human dental pulp stem cells (DPSCs) on microglial pyroptosis positive effects functional recovery SCI models. However, major secretory product CM responsible for inhibiting unclear. We aim investigate whether vascular endothelial growth factor (VEGF) secreted by DPSCs can alleviate through PI3K/AKT signaling pathway promote motor electrophysiological function mice. Human were isolated cultured, was collected VEGF detection further treatment. BV2 line established as model administration lipopolysaccharide (LPS). induced Molecular histological techniques employed evaluate explore underlying mechanisms both vivo vitro. DPSC-derived significantly inhibited vitro vivo, evidenced decreased expression pyroptosis-related markers, such caspase-1 IL-1β. anti-pyroptotic closely associated with activation pathway, which identified key regulatory mechanism. Importantly, treatment DPSC-CM improved conduction alleviates via thereby contributing repair provides new insights into potential therapy their factors, VEGF, offering perspectives
Language: Английский
Citations
0
Scientia Pharmaceutica, Journal Year: 2024, Volume and Issue: 92(1), P. 5 - 5
Published: Jan. 3, 2024
Taxifolin is a natural polyphenol belonging to the class of flavonoids. The structure this compound characterized by presence two chiral centers. spheroidal form taxifolin (TAXs) has emerged as promising modification due enhanced solubility, higher safety profile, and long-term release from solid dosage forms. study’s objective was assess diastereomeric content in TAXs industrially produced samples taxifolin. Considering difference physico-chemical properties diastereomers based on literature data, we developed qualitative HPLC method. chromatograms were recorded using diode array detector at 290 nm mass spectrometer operated negative ionization mode. Our data suggest that biphenyl column gradient elution 0.1% formic acid water 0.2% methanol, with organic phase 7% 21% flow rate 0.65 mL/min for 15 min 60 °C, provides best conditions separation diastereomers. This method validated quantitative analysis. We discovered cis-isomer present all analyzed samples, its quantity ranging 0.8% 9.5%. can be considered sample enriched
Language: Английский
Citations
3
Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(5)
Published: Feb. 8, 2024
Abstract Nelumbo nucifera Gaertn is a recognised herbal plant in ancient medical sciences. Each portion of the leaf, flower, seed and rhizome utilised for nutritional medicinal purposes. The chemical compositions like phenol, alkaloids, glycoside, terpenoids steroids have been isolated. contains various values lipids, proteins, amino acids, minerals, carbohydrates, fatty acids. Traditional medicine confirms that phytochemicals plants give significant benefits to treatment diseases such as leukoderma, smallpox, dysentery, haematemesis, coughing, haemorrhage, metrorrhagia, haematuria, fever, hyperlipidaemia, cholera, hepatopathy hyperdipsia. To verify traditional claims, researchers conducted scientific biological vivo vitro screenings, which exhibited keeps notable pharmacological activities anticancer, hepatoprotective, antioxidant, antiviral, hypolipidemic, anti‐obesity, antipyretic, hypoglycaemic, antifungal, anti‐inflammatory antibacterial activities. This review, summaries composition, constituents substantiated by done .
Language: Английский
Citations
3
Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(26), P. 14727 - 14746
Published: June 22, 2024
: Following spinal cord injury (SCI), autophagy plays a positive role in neuronal protection, whereas pyroptosis triggers an inflammatory response. Ginsenoside-Rh2 (GRh2), known for its neuroprotective effects, is considered promising drug. However, the exact molecular mechanisms underlying these protective effects remain unclear.
Language: Английский
Citations
3
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112891 - 112891
Published: Aug. 16, 2024
Language: Английский
Citations
3