Molecular Biotechnology, Journal Year: 2023, Volume and Issue: unknown
Published: Nov. 30, 2023
Language: Английский
Frontiers in Bioscience-Landmark, Journal Year: 2024, Volume and Issue: 29(6), P. 210 - 210
Published: June 11, 2024
Traumatic spinal cord injury (SCI) is a serious disease of the central nervous system. Aside from limited intrinsic regenerative capacity neurons, complex microenvironmental disturbances can also lead to further cellular damage and growth inhibition. Programmed cell death regulated by pyroptosis has an important role in pathogenesis SCI. While there been wealth new knowledge regarding pyroptosis, detailed understanding its SCI possible therapeutic strategies still lacking. This review summarizes current advances regulatory pyroptosis-regulated inflammasome components inhibitory microenvironment following SCI, as well recent advances.
Language: Английский
Citations
2
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: June 18, 2024
Abstract The mechanism of spinal cord injury (SCI) is highly complex, and an increasing number studies have indicated the involvement pyroptosis in physiological pathological processes secondary SCI. However, there limited bioinformatics research on pyroptosis-related genes (PRGs) This study aims to identify validate differentially expressed PRGs GEO database, perform analysis, construct regulatory networks explore potential mechanisms therapeutic targets for We obtained high-throughput sequencing datasets SCI rats mice from database. Differential analysis was conducted using “limma” package R (DEGs). These were then intersected with previously reported PRGs, resulting a set GO KEGG enrichment analyses, as well correlation performed both rat mouse models Additionally, protein–protein interaction (PPI) network constructed STRING website examine relationships between proteins. Hub identified Cytoscape software, intersection top 5 hub selected subsequent experimentally validated. Furthermore, competing endogenous RNA (ceRNA) mechanisms. gene expression profiles GSE93249, GSE133093, GSE138637, GSE174549, GSE45376, GSE171441_3d GSE171441_35d this study. 10 12 respectively. Six common DEGs PRGs. Enrichment these that mainly focused inflammation-related factors, while showed most enriched NOD-like receptor signaling pathway. ceRNA consisted five important 24 miRNAs 34 lncRNAs. revealed three validated model, showing high Pyroptosis involved may play significant role its pathogenesis. associated deserve further in-depth research.
Language: Английский
Citations
2
Neural Regeneration Research, Journal Year: 2024, Volume and Issue: 20(10), P. 2787 - 2806
Published: July 29, 2024
Regulated cell death is a form of that actively controlled by biomolecules. Several studies have shown regulated plays key role after spinal cord injury. Pyroptosis and ferroptosis are newly discovered types deaths been to exacerbate inflammation lead in damaged cords. Autophagy, complex interconnected with various mechanisms, has garnered significant attention the study This injury triggers not only but also cellular survival responses. Multiple signaling pathways play pivotal roles influencing processes both deterioration repair regulating pyroptosis, ferroptosis, autophagy. Therefore, this review aims comprehensively examine mechanisms underlying deaths, modulate these potential therapeutic targets for Our analysis suggests targeting common regulatory different could be promising strategy promote enhance Moreover, holistic approach incorporates multiple their presents multi-target management
Language: Английский
Citations
2
Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17
Published: May 2, 2024
Valeriana jatamansi Jones (VJJ), renowned for its extensive history in traditional Chinese medicine and ethnomedicine within China, is prevalently utilized to alleviate ailments such as epigastric distension pain, gastrointestinal disturbances including food accumulation, diarrhea, dysentery, well insomnia other diseases. Moreover, the Iridoid-rich fraction derived from (IRFV) has demonstrated efficacy facilitating recuperation of motor functions after spinal cord injury (SCI). This study aimed investigate therapeutic effect IRFV on SCI underlying mechanism. Initially, a rat model was developed assess impact axonal regeneration. Subsequently, employing PC12 cell oxidative damage, role mechanism enhancing regeneration were explored using phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) signaling pathway inhibitor LY294002. Ultimately, same administered rats confirm molecular through which promotes by activating PI3K/Akt pathway. The results showed that significantly enhanced function recovery, reduced pathological injury, facilitated rats. In vitro experiments revealed improved viability, augmented regeneration, activated Notably, inhibition this negated benefits conclusion, promote recovery activation
Language: Английский
Citations
1
Molecular Biotechnology, Journal Year: 2023, Volume and Issue: unknown
Published: Nov. 30, 2023
Language: Английский
Citations
2