International Immunopharmacology, Journal Year: 2024, Volume and Issue: 139, P. 112699 - 112699
Published: July 17, 2024
Language: Английский
Journal of Neurosurgical Anesthesiology, Journal Year: 2024, Volume and Issue: 36(4), P. 278 - 282
Published: July 31, 2024
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as an increasingly popular class of medications commonly used for glycemic control in patients with type 2 diabetes mellitus and weight loss. GLP-1 RAs also potential benefits various neurological diseases independent their glucose-modulating effect. In this focused review, we explore animal clinical evidence evaluating the impact common diseases. Our aim is to provide a basis hypothesis generation future studies assess role that may on nervous system, including implications perioperative period.
Language: Английский
Citations
1
Cureus, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 19, 2024
Multiple sclerosis (MS) is a chronic, progressive autoimmune disease modulated by autoantibodies that inflame and destroy the myelin sheath encasing neuronal axons, impairing proper axonal conduction function. Glucagon-like peptide-1 (GLP-1) receptor agonists have been demonstrated to exert anti-inflammatory neuroprotective effects, making these drugs particularly exciting prospects in treatment of MS. While exact mechanism remains unclear, GLP-1 may modulate inflammatory responses targeting receptors present on immune cells such as macrophages, monocytes, lymphocytes. In animal models, shown significantly delay onset severity experimental encephalopathy symptoms, well increase nerve myelination brain weight. further experiments using models crush injury, specimens given reported significant rate density regeneration compared controls. Thus, show promise both prophylactic symptomatic for MS provide utility other autoimmune, inflammatory, neurodegenerative conditions.
Language: Английский
Citations
1
Journal of Diabetes and its Complications, Journal Year: 2024, Volume and Issue: 38(12), P. 108906 - 108906
Published: Nov. 12, 2024
Language: Английский
Citations
1
Published: Jan. 1, 2024
The concept that the gut microbiota plays a significant role in maintaining physiological status gastrointestinal (GI) system is supported by both qualitative and quantitative transformation of intestinal flora various pathological conditions, as revealed research studies. A relationship between cognitive functioning clearly suggested evidence neuroinflammation seen neurodegenerative illnesses like Parkinson's Alzheimer's. Many factors will affect or influence microbiota. Dysbiosis microbiome linked to decreased immune response, which encourages growth skin diseases causes hair-related disturbances. Gut alteration related many skins disorders. Gut-brain cross-talk has significantly improved interaction hormones. Ayurveda can be applied cosmetics balance symbiosis microbial ecology using organic plant botanicals. According this perspective, non-pathological aging process may facilitated modulating microbiota, considers interdependence products, inflammation mediators, system. It also help contrast advancement degenerative mechanisms. Certain investigations, with encouraging outcomes, have already characterized elderly people. connection aging, plague older people should better understood through future research.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 139, P. 112699 - 112699
Published: July 17, 2024
Language: Английский
Citations
0