PDCD5 as a Potential Biomarker for Improved Prediction of the Incidence and Remission for Patients with Rheumatoid Arthritis DOI Creative Commons
Juan Xiao, Fengqiao Zhou, Zhen-Wang Zhao

et al.

Rheumatology and Therapy, Journal Year: 2023, Volume and Issue: 10(5), P. 1369 - 1383

Published: Aug. 1, 2023

Rheumatoid arthritis (RA) often involves an altered T-cell subpopulation, higher levels of inflammatory cytokines, and auto-antibodies. This study investigated whether PDCD5 could be a biomarker to predict the incidence remission RA so as guide therapeutic management clinical RA.One hundred fifty-two patients (41 being in both active status stable status) who were newly diagnosed with 38 healthy controls enrolled. Basic data collected before using blood samples remaining clinic after routine complete count. The ability important indicators was estimated based on receiver operating characteristic curve (ROC) analysis.PDCD5 expression found significantly increased comparison or those status. Compared anti-CCP, ESR DAS28 score, better predictive value AUC 0.846 (95% CI 0.780-0.912) for remission. risk (OR = 1.73, 95% 1.45-1.98, P 0.005) multiple logistic regression analysis, increasing by 2.94-times high-risk group low-risk 2.94, 2.35-4.62, < 0.001). association between showed similar result. For correlation significant associations eventually indicated genes (FOXP3, TNF-α, IL-17A, IFN-γ IL-6) well several parameters including IgG, RF, CRP, ESR, anti-CCP score.This suggested that linked RA. may used novel prediction remission, especially due its potential involvement development condition.

Language: Английский

Bidirectional modulation of extracellular vesicle-autophagy axis in acute lung injury: Molecular mechanisms and therapeutic implications DOI Open Access
Linqiang Tian, Jie Jin, Qianying Lu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117566 - 117566

Published: Oct. 17, 2024

Language: Английский

Citations

3
Camellia saponin modulates oleic acid/linoleic acid‐induced lipogenesis in human sebocytes through lipophagy activation DOI Open Access

Kaibo Wan,

Jian Li, Nyuk Ling

et al.

International Journal of Cosmetic Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Background Oily skin not only threatens people with aesthetic and hygienic discomfort but also confronts them annoying problems. To explore new care ingredients from herbal or plant extracts understand their underlying mechanism for sebum control would assist in the discovery of desirable sebosuppressive agents, though it is still a deserving challenging task. Aim effect Camellia saponin (CS) on modulating lipogenesis human sebocytes. Moreover, to CS oleic acid/linoleic acid (OL) mixture stimulated lipid accumulation. Methods The accumulation model cells was constructed by OL‐induction vitro. synthesis SZ95 sebocytes detected Oil Red O, Nile BODIPY staining distribution droplets autophagosomes were evaluated transmission electron microscopy (TEM). Fluorescence staining, immunofluorescence western blot (WB) used characterize spatial localization (LDs)/autophagosome/lysosome, levels LC3 P62 proteins related intracellular autophagy, as well pH lysosome. Results treatment significantly relieved OL‐induced Furthermore, maintained lysosomal environment promote fusion autophagosome lysosome, thus recovering blockage autophagy flow. We found that activated AMPK, down‐regulated mTOR Conclusion able relieve OL‐stimulated cultured through lipophagy, which process AMPK/mTOR pathway.

Language: Английский

Citations

0
Kirenol alleviates cerebral ischemic injury by promoting synaptic plasticity via HDAC2-mediated BDNF expression DOI
Min Guo,

Yonghua Ye,

Xuezhen Li

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156605 - 156605

Published: March 1, 2025

Language: Английский

Citations

0
Metformin derivatives – Researchers’ friends or foes? DOI Creative Commons

Sema Tuna Torunoglu,

Agnieszka Zajda, Janne Tampio

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 215, P. 115743 - 115743

Published: Aug. 15, 2023

Metformin has been used for ages to treat diabetes mellitus due its safety profile and low cost. However, metformin variable pharmacokinetics in patients, poor oral absorption, the therapeutic doses are relatively high, causing unpleasant gastrointestinal adverse effects. Therefore, novel derivatives of have synthesized during past decades. Particularly, after mid-2000s, when organic cation transporters were identified as main carriers, under intensive investigation. Nevertheless, biguanide structure, challenging synthesize. Moreover, mechanisms metformin's action not fully understood date, since it multifunctional properties, interests switched re-purposing other diseases. Indeed, demonstrated many cases be more effective than itself potential different diseases, including several types cancers neurodegenerative On hand, pleiotropic nature can also create challenges. Not all properties fit In this review, history development metformin-like compounds is summarized, insights into their future drug discovery discussed.

Language: Английский

Citations

8
TM9SF1 expression correlates with autoimmune disease activity and regulates antibody production through mTOR-dependent autophagy DOI Creative Commons
Juan Xiao, Zhen-Wang Zhao, Fengqiao Zhou

et al.

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 31, 2024

Transmembrane 9 superfamily member 1 (TM9SF1) is involved in inflammation. Since both inflammatory and autoimmune diseases are linked to immune cells regulation, this study investigated the association between TM9SF1 expression disease activity. As B cell differentiation autoantibody production exacerbate disease, signaling pathways these processes were explored.

Language: Английский

Citations

2
Kirenol Ameliorates Myocardial Ischemia–Reperfusion Injury by Promoting Mitochondrial Function and Inhibiting Inflammasome Activation DOI
Lei Pan, Mingqiang Fu,

Xianglin Tang

et al.

Cardiovascular Drugs and Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

Language: Английский

Citations

2
Regulation of Bacillus Calmette-Guérin-induced macrophage autophagy and apoptosis by the AMPK–mTOR–ULK1 pathway DOI
Ruiqian Li, Tianle He, Min Yang

et al.

Microbiological Research, Journal Year: 2024, Volume and Issue: unknown, P. 127952 - 127952

Published: Oct. 1, 2024

Language: Английский

Citations

1
Hydrogen-rich solution alleviates acute radiation pneumonitis by regulating oxidative stress and macrophages polarization DOI Creative Commons

Zhen Yin,

Wenjing Xu,

Junjun Ling

et al.

Journal of Radiation Research, Journal Year: 2024, Volume and Issue: 65(3), P. 291 - 302

Published: April 6, 2024

Abstract This study was aimed to investigate the effect of hydrogen-rich solution (HRS) on acute radiation pneumonitis (ARP) in rats. The ARP model induced by X-ray irradiation. Histopathological changes were assessed using HE and Masson stains. Inflammatory cytokines detected ELISA. Immunohistochemistry flow cytometry performed quantify macrophage (CD68) levels M2/M1 ratio. Western blot analysis, RT-qPCR, ELISA used evaluate mitochondrial oxidative stress injury indicators. Immunofluorescence double staining colocalize CD68/LC3B p-AMPK-α/CD68. relative expression proteins associated with autophagy activation adenosine 5′-monophosphate-activated protein kinase/mammalian target rapamycin/Unc-51-like kinase 1 (AMPK/mTOR/ULK1) signaling pathway western blotting. decreased body weight, increased lung coefficient, collagen deposition infiltration promoted M1 polarization After HRS treatment, pathological damage alleviated, inhibited. Furthermore, treatment reversed ARP-induced high inhibition. Importantly, phosphorylation AMPK-α inhibited, mTOR ULK1 activated rats this treatment. inhibited alleviated activate regulating AMPK/mTOR/ULK1 pathway.

Language: Английский

Citations

1
Mechanism of XiJiaQi in the treatment of chronic heart failure: Integrated analysis by pharmacoinformatics, molecular dynamics simulation, and SPR validation DOI Creative Commons
Dongyang Zhao, Kaijing Guo,

Qian Zhang

et al.

Computers in Biology and Medicine, Journal Year: 2023, Volume and Issue: 166, P. 107479 - 107479

Published: Sept. 21, 2023

Chronic heart failure (CHF) is a complicated clinical syndrome with high mortality rate. XiJiaQi (XJQ) traditional Chinese medicine used in the treatment of CHF, but its bioactive components and their modes action remain unknown. This study was designed to unravel molecular mechanism XJQ CHF using multiple computer-assisted experimental methods.

Language: Английский

Citations

3
Distribution of FEN1 mediated by TM9SF1: unraveling the potential mechanisms of DNA damage DOI Creative Commons
Fengqiao Zhou, Lu Zhang, Huabo Chen

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 22, 2024

Abstract Transmembrane 9 superfamily protein member 1 (TM9SF1) has abnormal overexpression in specific clinical diseases; however, its precise role disease progression remains poorly understood. The current study revealed the critical importance of maintaining appropriate TM9SF1 levels for proper distribution FEN1, a crucial DNA repair. interacted with FEN1 through N-terminal region spanning amino acids 1-236, which could translocate into nucleus, while C-terminal segment 237–606 was responsible cellular localization TM9SF1. Overexpression led to sequestration cytoplasm, thus hindering FEN1’s entry nucleus. Consequently, repair capacity compromised, leading increased damage and subsequently cell growth inhibition. Moreover, knockdown 293T cells or knockout mouse kidney did not affect expression induction. mechanism abnormally high occurrence development diseases, positioning as potential drug target.

Language: Английский

Citations

0