Antioxidant and anti-inflammatory effects of selenomethionine promote osteogenesis via Wnt/β-Catenin pathway DOI Creative Commons
Guodong Zhao,

Yiting Zhang,

Yinping Tian

et al.

Biochemistry and Biophysics Reports, Journal Year: 2023, Volume and Issue: 36, P. 101559 - 101559

Published: Oct. 19, 2023

Recently, the antioxidant properties of natural compound, selenomethionine (Se-Met), have been recognized. However, its effect on osteogenic mineralization Wnt/β-Catenin pathway under conditions oxidative stress and inflammation remain unclear.This study utilized tert-butyl hydroperoxide (TBHP) to simulate inflammation. Se-Met was then subsequently used inhibit these effects in vitro.TBHP induces inflammatory responses by increasing expression reactive oxygen species NLRP3, whereas decreasing GPX4, thereby inhibiting viability MC3T3-E1 cells. TBHP further promotes lipid peroxidation damages ultrastructure mitochondria. Furthermore, inhibits levels β-Catenin, reducing activity Wnt pathway, which turn suppresses differentiation capacity. Importantly, significantly alters aforementioned enhance pathway-related proteins improving capacity cells.Se-Met enhances anti-inflammatory cells via signaling promote osteogenesis. Thus, plays a crucial role field bone homeostasis, presents an opportunity for future development novel drugs treating osteoporosis maintaining stability. detailed preclinical animal studies are required generate solid reliable data aid this development.

Language: Английский

Kaempferol improves depression-like behaviors through shifting microglia polarization and suppressing NLRP3 via tilting the balance of PPARγ and STAT1 signaling DOI

Paul Su,

Liming Liu,

Yuhang Gong

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113538 - 113538

Published: Nov. 3, 2024

Language: Английский

Citations

2
Pyridazine Derivatives as NLRP3 Inhibitors for Treating Asthma, COPD, Parkinson’s Disease, and Alzheimer’s Disease DOI Open Access
Ram W. Sabnis

ACS Medicinal Chemistry Letters, Journal Year: 2023, Volume and Issue: 14(8), P. 1047 - 1048

Published: Aug. 1, 2023

Provided herein are novel pyridazine derivatives as NLRP3 inhibitors, pharmaceutical compositions, use of such compounds in treating asthma, COPD, Parkinson's disease, and Alzheimer's processes for preparing compounds.

Language: Английский

Citations

4
Melatonin Attenuates Methamphetamine Neurotoxicity through inhibition of NLRP3 and pyroptosis pathway DOI Creative Commons

Seyed Khalil Rashidi,

Mitra Ansari Dezfouli, Fariba Khodagholi

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 28(4), P. 430 - 439

Published: Dec. 1, 2024

Language: Английский

Citations

1
Fused Bicyclic Heteroaryl Compounds as NLRP3 Inhibitors for Treating Asthma or COPD DOI Creative Commons
Ram W. Sabnis

ACS Medicinal Chemistry Letters, Journal Year: 2023, Volume and Issue: 14(7), P. 895 - 896

Published: June 6, 2023

Provided herein are novel fused bicyclic heteroaryl compounds as NLRP3 inhibitors, pharmaceutical compositions, use of such in treating asthma or COPD and processes for preparing compounds.

Language: Английский

Citations

1
Antioxidant and anti-inflammatory effects of selenomethionine promote osteogenesis via Wnt/β-Catenin pathway DOI Creative Commons
Guodong Zhao,

Yiting Zhang,

Yinping Tian

et al.

Biochemistry and Biophysics Reports, Journal Year: 2023, Volume and Issue: 36, P. 101559 - 101559

Published: Oct. 19, 2023

Recently, the antioxidant properties of natural compound, selenomethionine (Se-Met), have been recognized. However, its effect on osteogenic mineralization Wnt/β-Catenin pathway under conditions oxidative stress and inflammation remain unclear.This study utilized tert-butyl hydroperoxide (TBHP) to simulate inflammation. Se-Met was then subsequently used inhibit these effects in vitro.TBHP induces inflammatory responses by increasing expression reactive oxygen species NLRP3, whereas decreasing GPX4, thereby inhibiting viability MC3T3-E1 cells. TBHP further promotes lipid peroxidation damages ultrastructure mitochondria. Furthermore, inhibits levels β-Catenin, reducing activity Wnt pathway, which turn suppresses differentiation capacity. Importantly, significantly alters aforementioned enhance pathway-related proteins improving capacity cells.Se-Met enhances anti-inflammatory cells via signaling promote osteogenesis. Thus, plays a crucial role field bone homeostasis, presents an opportunity for future development novel drugs treating osteoporosis maintaining stability. detailed preclinical animal studies are required generate solid reliable data aid this development.

Language: Английский

Citations

1