Microbial Cell Factories,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Oct. 16, 2024
Carbapenem-resistant
Acinetobacter
baumannii
denotes
a
significant
menace
to
public
health,
and
it
mandates
an
urgent
development
of
new
effective
medications.
Here,
we
aimed
estimate
the
efficiency
zinc
oxide
nanoparticles
(ZnO
NP)
biosynthesized
from
Arthrospira
maxima
(Spirulina)
both
in
vitro
vivo.
A.
isolates
were
collected,
identified,
tested
for
their
antibiotic
susceptibility,
then
subjected
PCR
detect
carbapenemase-producing
genes.
The
most
predominant
carbapenemase
resistance
gene
was
bla
World Journal of Gastroenterology,
Journal Year:
2023,
Volume and Issue:
29(43), P. 5848 - 5864
Published: Nov. 20, 2023
Atractylodes
japonica
Koidz.
ex
Kitam.
(A.
japonica,
Chinese
name:
Guan-Cangzhu,
Japanese
Byaku-jutsu),
a
perennial
herb,
which
is
mainly
distributed
in
northeast
area
of
China,
it's
often
used
to
treat
digestive
system
diseases
such
as
gastric
ulcer
(GU).
However,
the
mechanism
its
potential
protective
effects
against
GU
remains
unclear.To
investigate
A.
on
acetic
acid-induced
rats.The
chemical
constituents
were
determined
by
ultra
performance
liquid
chromatography
tandem
mass
spectrometry
(UPLC-MS/MS)
analysis.
The
rat
model
was
simulated
acid
method.
pathological
changes
tissues
evaluated
hematoxylin-eosin
stain,
levels
epidermal
growth
factor
(EGF),
EGF
receptor
(EGFR),
nuclear
kappa-B
(NF-κB),
interleukin-1β
(IL-1β),
IL-10,
Na+-K+-ATPase
(NKA)
serum
and
enzyme-linked
immunosorbent
assay,
mRNA
expressions
EGFR,
NF-κBp65,
IkappaBalpha
(IκBα)
Zonula
Occludens-1
(ZO-1)
real-time
reverse
transcription
polymerase
chain
reaction,
efficacy
observed.
Then,
plasma
metabolomic
analysis
performed
UPLC-MS/MS
screen
specific
biomarkers,
metabolic
pathways
explore
possible
mechanisms.48
identified.
Many
them
have
strong
pharmacological
activity,
results
also
revealed
that
significantly
improved
damage
tissues,
increased
expression
IκBα
related
anti-inflammatory
factors,
decreased
IL-1β,
NF-κB,
proinflammatory
restored
factors
about
EGF,
ZO-1
associated
with
healing
NKA
energy
metabolism.
Metabolomic
identified
10
differential
metabolites
enriched
7
pathways.These
findings
contribute
understanding
improve
GU,
will
be
great
importance
for
development
clinical
application
natural
drugs
japonica.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Feb. 12, 2024
Abstract
The
aim
of
this
study
was
to
investigate
the
potential
Ipomoea
carnea
flower
methanolic
extract
(ICME)
as
a
natural
gastroprotective
therapy
against
ethanol-induced
gastric
ulcers,
particularly
in
individuals
exposed
ionizing
radiation
(IR).
focused
on
Nrf2/HO−1
signaling
pathway,
which
plays
crucial
role
protecting
gastrointestinal
mucosa
from
oxidative
stress
and
inflammation.
Male
Wistar
rats
were
divided
into
nine
groups,
control
group
received
distilled
water
orally
for
one
week,
while
other
groups
treated
with
ethanol
induce
stomach
IR
exposure,
omeprazole,
different
doses
ICME
combination
and/or
IR.
conducted
comprehensive
analyses,
including
LC-HRESI-MS/MS,
characterize
phenolic
contents
ICME.
Additionally,
parameters,
pH,
histopathological
changes
examined.
results
showed
that
exhibited
alterations,
increased
lipid
peroxidation,
decreased
antioxidant
enzyme
activity,
reduced
expression
levels
Nrf2
HO−1.
However,
pretreatment
significantly
improved
these
parameters.
Phytochemical
analysis
identified
39
compounds
ICME,
flavonoids,
hydroxybenzoic
acids,
fatty
acids
predominant
compounds.
Virtual
screening
molecular
dynamics
simulations
suggested
may
protect
ulceration
by
inhibiting
inflammatory
mediators.
In
conclusion,
demonstrates
preventing
ulcers.
These
findings
contribute
development
novel
interventions
disorders
using
plant
extracts
history
exposure
.
Microbial Cell Factories,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Oct. 16, 2024
Carbapenem-resistant
Acinetobacter
baumannii
denotes
a
significant
menace
to
public
health,
and
it
mandates
an
urgent
development
of
new
effective
medications.
Here,
we
aimed
estimate
the
efficiency
zinc
oxide
nanoparticles
(ZnO
NP)
biosynthesized
from
Arthrospira
maxima
(Spirulina)
both
in
vitro
vivo.
A.
isolates
were
collected,
identified,
tested
for
their
antibiotic
susceptibility,
then
subjected
PCR
detect
carbapenemase-producing
genes.
The
most
predominant
carbapenemase
resistance
gene
was
bla
