Terminalia chebula Retz. extract relieves gout arthritis by inhibiting xanthine oxidase, the uric acid transporter, and NLRP3 inflammasome activation

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119848 - 119848

Published: April 1, 2025

Language: Английский

---

Progress in oral biomaterials for the treatment of metabolic bone diseases

Progress in Materials Science, Journal Year: 2025, Volume and Issue: unknown, P. 101499 - 101499

Published: April 1, 2025

Language: Английский

---

Primary cilia and inflammatory response: unveiling new mechanisms in osteoarthritis progression

Experimental Biology and Medicine, Journal Year: 2025, Volume and Issue: 250

Published: April 28, 2025

Osteoarthritis (OA) is a common degenerative joint disease that can lead to chronic pain and disability. The pathogenesis of OA involves low-grade inflammation, characterized by the degradation chondrocytes, inflammation synovium, systemic inflammation. This inflammatory response accelerates progression contributes functional impairment. Primary cilia play crucial role in cellular signal transduction maintenance cartilage matrix homeostasis, their dysfunction closely linked responses. Given these roles, primary may significantly contribute OA. review explores inflammation-associated signaling pathways OA, including NF-κB, MAPK, JAK/STAT, PI3K/AKT/mTOR signaling. In addition, we place particular emphasis on cilia-mediated modulation mediate chondrocyte responses mechanical loading cytokines via TRPV4, Hedgehog Notably, alterations length incidence chondrocytes during further underscore potential pathogenesis. identification biomarkers therapeutic targets related offers new for treatment management

Language: Английский

---

Inflammation unleashed: The role of pyroptosis in chronic liver diseases

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 113006 - 113006

Published: Aug. 29, 2024

Pyroptosis, a newly identified form of programmed cell death intertwined with inflammatory responses, is facilitated by the Gasdermin family's pore-forming activity, leading to lysis and release pro-inflammatory cytokines. This process double-edged sword in innate immunity, offering protection against pathogens while risking excessive inflammation tissue damage when dysregulated. Specifically, pyroptosis operates through two distinct signaling pathways, namely Caspase-1 pathway Caspase-4/5/11 pathway. In context chronic liver diseases like fibrosis cirrhosis, emerges as central contributing factor their pathogenesis. The identification characterized activation immune cells secretion cytokines such IL-1α, IL-1β, TNF-α. review explores interrelationship between inflammasome, protein complex located that recognizes danger signals initiates activation, resulting IL-1β IL-18. article delves into influence inflammasome on various disorders, specific focus molecular pathophysiological mechanisms. Additionally, potential therapeutic implications targeting for are highlighted future consideration.

Language: Английский

---

Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation

Acta Pharmacologica Sinica, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Language: Английский

---

The Therapeutic Management of Chemical and Herbal Medications on Uric Acid Levels and Gout: Modern and Traditional Wisdom

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(11), P. 1507 - 1507

Published: Nov. 9, 2024

Gout is a chronic inflammatory condition characterized by elevated uric acid levels in the blood, which can precipitate acute gout attacks individuals with genetic susceptibility, existing medical conditions, and dietary influences. Genetic predispositions, comorbid nutritional choices, environmental factors increasingly recognize multifactorial etiology of disease.

Language: Английский

---

Causal relationship between inflammatory proteins, immune cells, and gout: a Mendelian randomization study

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 3, 2024

Prior research has documented the association between certain circulating inflammatory proteins/immune cells and gout. However, reliability of these associations remains contentious due to constraints conventional observational methodologies. This investigation seeks reassess causative link gout through application Mendelian randomization (MR). The study included 3576 individuals European ancestry with gout, immune cell data from GWAS summary 3757 Sardinians, protein 14,824 participants for MR analysis. principal approach employed was inverse variance weighted analysis investigate causal relationship exposure outcomes. results indicate that CD28 on CD39+ CD4+ T may be associated a reduced risk Additionally, CD45RA+ CD28- CD8bright also In contrast, DN (CD4-CD8-) IL-12β increase Some proteins show potential Nevertheless, additional experimental verification is warranted assess underlying mechanisms confirm role factors in pathogenesis.

Language: Английский

---

Palmatine, an isoquinoline alkaloid from Phellodendron amurense Rupr., ameliorated gouty inflammation by inhibiting pyroptosis via NLRP3 inflammasome

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 340, P. 119231 - 119231

Published: Dec. 17, 2024

Language: Английский

---

JUN and ATF3 in gout: Ferroptosis-related potential diagnostic biomarkers

Heliyon, Journal Year: 2024, Volume and Issue: 10(22), P. e39957 - e39957

Published: Oct. 31, 2024

Language: Английский

---

Resolution of acute inflammation induced by monosodium urate crystals (MSU) through neutrophil extracellular trap-MSU aggregate-mediated negative signaling

Journal of Inflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Nov. 27, 2024

Abstract Background Polymorphonuclear neutrophils (PMN) activation by monosodium urate crystals (MSU) is crucial to acute gouty arthritis and subsequent spontaneous remission within 7–10 days. Activated PMNs release neutrophil extracellular traps (NETs) that entrap MSU crystals, forming NET-MSU aggregates. Whether aggregates contribute the resolution of inflammation remains be elucidated. This study uses a cell-based approach unveil their molecular bases. Methods All-trans retinoic acid-differentiated HL-60 cells (dHL-60) served as surrogate PMNs. NET from MSU-activated dHL-60 was confirmed detecting DNA, elastase, citrullinated histone 3, large area measured with Fiji software after SYTOX Green staining. Released pro-inflammatory cytokines IL-8 TNF-α, anti-inflammatory cytokine IL-1RA in culture supernatants were quantified calculate estimate score (EIS). Cellular redox state determined FRET-based sensor. Expression intracellular positive (ERK1/2) negative (SHP-1 SHIP-1) signaling regulators detected western blot. qPCR mRNA expressions CISH SOCS1–SOCS7. Flow cytometry N1 (CD54) N2 (CD182) surface markers staining fluorescent-conjugated antibodies. Results Incubating for 4 h maximized aggregate formation an EIS 11.6. Prolonging incubation + 22 gradually raised 19.40 without increasing area, due reduced cellular capacity. Adding both new culture, mimicking clinical scenario, increased but conversely suppressed 1.53, indicating resolution. The following prolonged attributed decreases P-ERK increases P-SHP-1, SOCS2, SOCS3, gene expressions, which may suppress enhance production. Moreover, facilitated polarization, accelerating Conclusion We explored potential basis induced using model huge frustrate transformation newly entering phenotype, enhancing production IL-1RA.

Language: Английский

---