Applied and Environmental Microbiology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 6, 2025
ABSTRACT Antimicrobial peptides (AMPs) have emerged as potential alternatives to conventional antibiotics due their novelty and multiple mechanisms of action. Because they are peptides, AMPs amenable bioengineering suitable for cloning expression at large production scales. However, the efficient delivery is an unaddressed issue, particularly size, possible toxicities, development adverse immune responses. Here, we reviewed possibilities adeno-associated virus (AAV)-based localized gene treatment infectious diseases with a special focus on respiratory infections. By discussing mechanism AAV accompanying technical therapeutic challenges AMPs, describe foundation that emphasizes use viral vector-based disease treatment.
Language: Английский
Citations
1Gut-Antimicrobial Peptides: Synergistic Co-Evolution with Antibiotics to Combat Multi-Antibiotic Resistance
Antibiotics, Journal Year: 2023, Volume and Issue: 12(12), P. 1732 - 1732
Published: Dec. 14, 2023
Due to huge diversity and dynamic competition, the human gut microbiome produces a diverse array of antimicrobial peptides (AMPs) that play an important role in health. The has maintaining homeostasis by AMPs interacting with other organs via established connections such as gut-lung, gut-brain axis. Additionally, synergistic microbiota antimicrobials maintain fighting against multi-antibiotic resistance (MAR) bacteria. Further, conventional antibiotics intake creates evolutionary pressure for AMPs, where fight synergistically MAR. Overall, are evolving under complex highly co-evolutionary created various interactions between microbiota, antibiotics; however, complete mechanism is not well understood. current review explores action along possibilities MAR
Language: Английский
Citations
13Synthesis of a tetralone derivative of ampicillin to control ampicillin-resistant Staphylococcus aureus
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 714, P. 149974 - 149974
Published: April 20, 2024
Language: Английский
Citations
3Marine Bacteriocins: An Evolutionary Gold Mine to Payoff Antibiotic Resistance
Marine Drugs, Journal Year: 2024, Volume and Issue: 22(9), P. 388 - 388
Published: Aug. 28, 2024
The rapid evolution of drug resistance is one the greatest health issues 21st century. There an alarming situation to find new therapeutic strategies or candidate drugs tackle ongoing multi-drug development. marine environment prime natural ecosystems on Earth, majority which still unexplored, especially when it comes microbes. A wide variety bioactive compounds have been obtained from a varied range organisms; however, bacteria-produced bacteriocins are undermined. Owing distinct environmental stresses that bacterial communities encounter, their frequently undergo adaptations confer them shapes and functions, setting apart terrestrial counterparts. Bacterially produced ribosomally synthesized posttranslationally modified peptides (RiPPs), known as bacteriocins, special interests be considered alternative conventional antibiotics because in structure diverse potential biological activities. Additionally, gut microbiome creatures largely unexplored source with promising huge possibility novel might come out efficient candidates fight against antibiotic resistance, light growing pressure antibiotic-resistant diseases industrial desire for innovative treatments. present review summarizes fully characterized evolutionary aspects, challenges, possibilities ecosystems.
Language: Английский
Citations
2Marine Bacteriocins: An Evolutionary Gold Mine to Payoff Antibiotic Resistance
Published: Aug. 6, 2024
The rapid evolution of drug resistance is one the greatest health issues 21st century. There an alarming situation to find new therapeutic strategies or candidate drugs tackle ongoing multi-drug development. marine environment prime natural ecosystems on Earth, majority which still unexplored, especially when it comes microbes. A wide variety bioactive compounds have been obtained from a varied range organisms, however, bacteria-produced bacteriocins are undermined. Owing distinct environmental stresses that bacterial communities encounter, their frequently undergo adaptations confer them shapes and functions, setting apart terrestrial counterparts. ribosomally-synthesized posttranslationally modified peptides (RiPPs), special interest because in structure diverse potential biological activities. Additionally, gut microbiome creatures largely unexplored source with promising huge possibility novel might come out as efficient candidates fight against antibiotic resistance, light growing pressure antibiotic-resistant diseases industrial desire for innovative treatments. present review summarizes known bacteria, evolutionary aspects, challenges, possibilities communities.
Language: Английский
Citations
1Repurposing of Human Defensins as a Promising Antiviral Therapeutics Against SARS-CoV-2
Published: Jan. 1, 2024
Language: Английский
Citations
0Anti-Biofilm Action of Cineole and Hypericum perforatum to Combat Pneumonia-Causing Drug-Resistant P. aeruginosa
Antibiotics, Journal Year: 2024, Volume and Issue: 13(8), P. 689 - 689
Published: July 24, 2024
Hospital-acquired antibiotic-resistant pneumonia is one of the major causes mortality around world that pose a catastrophic threat.
Language: Английский
Citations
0Strategic Defenders: Antimicrobial Peptides and Their Impact on the Innate Immunity
Published: Jan. 1, 2024
Language: Английский
Citations
0Bacterial Antimicrobial Peptides: A Potential Alternative to Antibiotics
Published: Jan. 1, 2024
Citations
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