Cited by USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice

The role of Foxo3a in neuron-mediated cognitive impairment DOI

Qinqin Liu, Guihua Wu,

Xiaochun Wang

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: June 19, 2024

Cognitive impairment (COI) is a prevalent complication across spectrum of brain disorders, underpinned by intricate mechanisms yet to be fully elucidated. Neurons, the principal cell population nervous system, orchestrate cognitive processes and govern balance. Extensive inquiry has spotlighted involvement Foxo3a in COI. The regulatory cascade transactivation implicates multiple downstream signaling pathways encompassing mitochondrial function, oxidative stress, autophagy, apoptosis, collectively affecting neuronal activity. Notably, expression activity profile are subject modulation via various modalities, including methylation promoter, phosphorylation acetylation protein. Furthermore, upstream such as PI3K/AKT, SIRT family, diverse micro-RNAs intricately interface with Foxo3a, engendering alterations function. Through several routes, regulates dynamics, thereby modulating onset or amelioration COI Alzheimer’s disease, stroke, ischemic injury, Parkinson’s traumatic injury. potential therapeutic target, clinical drugs small molecules have been preliminarily shown cognitive-enhancing effects that indirectly affect Foxo3a. Particularly noteworthy randomized, controlled, placebo trials illustrating significant enhancement achievable through autophagy modulation. Here, we discussed role neuron-mediated common cognitively impaired diseases.

Language: Английский

Citations

Dual Mechanism of Docosahexaenoic acid (DHA) in Alzheimer’s Disease: PAD4 Inhibition and Autophagy Stimulation DOI

Haleh Barmaki,

Alireza Nourazarian, Hadi Yousefi

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

Citations

Quercetin improves homocysteine-induced learning and memory impairment in rats via AMPK/mTOR DOI

Xin Gong,

Rongzhi Xu,

D. X. Qi

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 27, 2024

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative brain disease. At present, the main treatment strategy to alleviate certain symptoms, but potential mechanisms of AD are not fully understood, and there lack effective methods in clinical practice. Quercetin (QT) can significantly protect neurodegeneration by inhibiting oxidative stress inflammation, has play greater role Therefore, this study aims explore mechanism QT based on AMPK/mTOR pathway improving learning memory abilities rats.For purpose,we established an rat model injecting Hcy into tail vein.After successful validation, AMPK inhibitor were gavaged.Then, protected nerve regeneration was determined using Morris water maze, Nissl staining, Western blot immunohistochemistry.We observed that improved models with AD, as demonstrated short latency times travel across platform. staining showed could reduce neurological Apoptosis amenorrate implementation .Western immunohistochemistry questionnaire increased p-AMPK, while reducing p-mTOR p-Tau .In addition, application specific effectively reverse these changes, further enhancing improvement effect inhibition Thereby induced rates, thus abilities.

Language: Английский

Citations

USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice DOI

Siyi Zheng,

Jiahui Zhu, Cailin Wang

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 24, 2024

Language: Английский

Citations