NCOA4 linked to endothelial cell ferritinophagy and ferroptosis:a key regulator aggravate aortic endothelial inflammation and atherosclerosis DOI Creative Commons

Li Zhu,

Zijian Liu, Jiahui Liu

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 79, P. 103465 - 103465

Published: Dec. 13, 2024

Language: Английский

The cGAS-STING pathway in atherosclerosis DOI Creative Commons
Siyu Wang, Yushan Chen, Bo Jin

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 25, 2025

Atherosclerosis (AS), a chronic inflammatory disease, remains leading contributor to cardiovascular morbidity and mortality. Recent studies highlight the critical role of cGAS-STING pathway—a key innate immune signaling cascade—in driving AS progression. This pathway is activated by cytoplasmic DNA from damaged cells, thereby triggering inflammation accelerating plaque formation. While risk factors such as aging, obesity, smoking, hypertension, diabetes are known exacerbate AS, emerging evidence suggests that these may also enhance pathway, which amplifies responses. Targeting this offers promising therapeutic strategy reduce burden diseases (CVD). In review, we summarize mechanisms explore its in evaluate potential inhibitors future candidates. By integrating current knowledge, aim provide insights for developing novel treatments mitigate CVD burden.

Language: Английский

Citations

0
Therapeutic landscape in systemic lupus erythematosus: mtDNA activation of the cGAS-STING pathway DOI
X Gu, Yong Chen,

Kunyu Cao

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 133, P. 112114 - 112114

Published: April 22, 2024

Language: Английский

Citations

2
Mitochondrial dysfunction, a weakest link of network of aging, relation to innate intramitochondrial immunity of DNA recognition receptors DOI
Dun‐Xian Tan

Mitochondrion, Journal Year: 2024, Volume and Issue: 76, P. 101886 - 101886

Published: April 24, 2024

Language: Английский

Citations

2
Neuroprotection of celastrol against postoperative cognitive dysfunction through dampening cGAS-STING signaling DOI

Xueshan Bu,

Hui Guo, Wenwei Gao

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 382, P. 114987 - 114987

Published: Oct. 5, 2024

Language: Английский

Citations

2
NCOA4 linked to endothelial cell ferritinophagy and ferroptosis:a key regulator aggravate aortic endothelial inflammation and atherosclerosis DOI Creative Commons

Li Zhu,

Zijian Liu, Jiahui Liu

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 79, P. 103465 - 103465

Published: Dec. 13, 2024

Language: Английский

Citations

2