Protective effect of canagliflozin on post-resuscitation myocardial function in a rat model of cardiac arrest DOI Creative Commons
Tianfeng Hua,

Yuqian Chu,

Minjie Wang

et al.

Intensive Care Medicine Experimental, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 15, 2023

Abstract Background Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological state in early stage of resuscitation, some may eventually progress to multiple organ failure. There is evidence that heart failure the terminal development various cardiovascular diseases. Although cardio-protective effect canagliflozin (CANA) has been confirmed large clinical studies recommended domestic international failure-related guidelines, effectiveness CANA after resuscitation remains unclear. In this study, we constructed a modified CA/CPR rat model investigate whether administered on post-resuscitation improves function. Methods Twenty-fourth healthy male Sprague–Dawley rats were randomized into four groups: (1) Sham + placebo group, (2) (3) CPR (4) group. Ventricular fibrillation was induced by transcutaneous electrical stimulation epicardium. After 6 min untreated ventricular fibrillation, chest compressions initiated. The received an injection or (3 ug/kg) randomly 15 restore spontaneous circulation (ROSC). Electrocardiogram (ECG) blood pressure continuously detected each group throughout experiment. killed h ROSC collected arterial serum tissue. Myocardial injury estimated concentrations inflammatory factors, oxidative stress indexes and, apoptosis index, markers, echocardiography pathological slices. Results mean (MAP) significantly increased cardiopulmonary when compared Heart rate, body lactate returned left ejection fraction (LVEF) normal levels shorter time obviously attenuated Inflammatory factors (IL-6, TNF-α) (MAD, SOD, CAT) dramatically decreased administration CANA. expression index (BAX, caspase-3) higher anti-apoptosis (Bcl-2) lower ( P < 0.05). Conclusions effectively reduces ischaemia/reperfusion I / R ) (CPR), underlying mechanism be related anti-inflammation, apoptosis.

Language: Английский

Natural products targeting AMPK signaling pathway therapy, diabetes mellitus and its complications DOI Creative Commons
Min Li,

Lu Ding,

L. Cao

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Diabetes mellitus (DM) ranks among the most prevalent chronic metabolic diseases, characterized primarily by a persistent elevation in blood glucose levels. This condition typically stems from either insufficient insulin secretion or functional defect itself. Clinically, diabetes is classified into type 1 (T1DM) and 2 (T2DM), with T2DM comprising nearly 90% of all diagnosed cases. Notably, global incidence has surged dramatically over recent decades. The adenylate-activated protein kinase (AMPK) signaling pathway crucial regulating cellular energy metabolism, marking it as significant therapeutic target for related complications. Natural products, their diverse origins, multifaceted bioactivities, relative safety, hold considerable promise modulating AMPK pathway. review article explores advances research on natural products that pathway, aiming to inform development innovative antidiabetic therapies.

Language: Английский

Citations

1
Mechanisms of mitophagy and oxidative stress in cerebral ischemia–reperfusion, vascular dementia, and Alzheimer’s disease DOI Creative Commons

Yu-Jie Lyu,

Zhipeng Meng,

Yun‐Yun Hu

et al.

Frontiers in Molecular Neuroscience, Journal Year: 2024, Volume and Issue: 17

Published: Aug. 7, 2024

Neurological diseases have consistently represented a significant challenge in both clinical treatment and scientific research. As research has progressed, the significance of mitochondria pathogenesis progression neurological become increasingly prominent. Mitochondria serve not only as source energy, but also regulators cellular growth death. Both oxidative stress mitophagy are intimately associated with mitochondria, there is mounting evidence that exert pivotal regulatory influence on diseases. In recent years, been notable rise prevalence cerebral ischemia/reperfusion injury (CI/RI), vascular dementia (VaD), Alzheimer’s disease (AD), which collectively represent public health concern. Reduced levels observed CI/RI, VaD AD. The improvement pathology demonstrated through increase levels. CI/RI results tissue ischemia hypoxia, causes stress, disruption blood–brain barrier (BBB) damage to vasculature. BBB may induce or exacerbate some extent. addition, inadequate perfusion due altered function accumulation amyloid β (Aβ) thereby contributing exacerbating AD pathology. Intravenous plasminogen activator (tPA; alteplase) endovascular thrombectomy effective treatments for stroke. However, narrow window opportunity administration tPA thrombectomy, markedly elevated incidence disability among patients CI/RI. It regrettable currently no still specific drugs Despite availability U.S. Food Drug Administration (FDA)-approved first-line AD, including memantine, donepezil hydrochloride, galantamine, these agents do fundamentally block pathological process this paper, we undertake review mechanisms disorders, summary trials conducted proposal new strategy targeted disorders based stress.

Language: Английский

Citations

5
Shenqi granules enhance recovery from cerebral ischemia-reperfusion injury by modulating tryptophan and tyrosine metabolism and activating NFE2L2/NRF2 DOI

Hai‐Xin Liu,

Mihi Yang, Yuchang Li

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156623 - 156623

Published: March 10, 2025

Language: Английский

Citations

0
Protective effect of canagliflozin on post-resuscitation myocardial function in a rat model of cardiac arrest DOI Creative Commons
Tianfeng Hua,

Yuqian Chu,

Minjie Wang

et al.

Intensive Care Medicine Experimental, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 15, 2023

Abstract Background Currently, most patients with cardiac arrest (CA) show reversible myocardial dysfunction, hemodynamic instability, systemic inflammation and other pathophysiological state in early stage of resuscitation, some may eventually progress to multiple organ failure. There is evidence that heart failure the terminal development various cardiovascular diseases. Although cardio-protective effect canagliflozin (CANA) has been confirmed large clinical studies recommended domestic international failure-related guidelines, effectiveness CANA after resuscitation remains unclear. In this study, we constructed a modified CA/CPR rat model investigate whether administered on post-resuscitation improves function. Methods Twenty-fourth healthy male Sprague–Dawley rats were randomized into four groups: (1) Sham + placebo group, (2) (3) CPR (4) group. Ventricular fibrillation was induced by transcutaneous electrical stimulation epicardium. After 6 min untreated ventricular fibrillation, chest compressions initiated. The received an injection or (3 ug/kg) randomly 15 restore spontaneous circulation (ROSC). Electrocardiogram (ECG) blood pressure continuously detected each group throughout experiment. killed h ROSC collected arterial serum tissue. Myocardial injury estimated concentrations inflammatory factors, oxidative stress indexes and, apoptosis index, markers, echocardiography pathological slices. Results mean (MAP) significantly increased cardiopulmonary when compared Heart rate, body lactate returned left ejection fraction (LVEF) normal levels shorter time obviously attenuated Inflammatory factors (IL-6, TNF-α) (MAD, SOD, CAT) dramatically decreased administration CANA. expression index (BAX, caspase-3) higher anti-apoptosis (Bcl-2) lower ( P < 0.05). Conclusions effectively reduces ischaemia/reperfusion I / R ) (CPR), underlying mechanism be related anti-inflammation, apoptosis.

Language: Английский

Citations

4