Metabolic Regulation of Inflammation: Exploring the Potential Benefits of Itaconate in Autoimmune Disorders DOI Open Access
Yin Luo,

Li‐Yan Jiang,

Zhe‐Zhen Liao

et al.

Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Itaconic acid and its metabolites have demonstrated significant therapeutic potential in various immune diseases. Originating from the tricarboxylic cycle cells, itaconic can modulate responses, diminish inflammation, combat oxidative stress. Recent research has uncovered multiple mechanisms through which exerts effects, including inhibition of inflammatory cytokine production, activation anti-inflammatory pathways, modulation cell function by regulating cellular metabolism. Cellular actions are influenced metabolic such as inhibiting succinate dehydrogenase (SDH) activity or glycolysis, nuclear-factor-E2-related factor 2 (Nrf2), boosting defences against stress, suppression inflammation NF-κB pathway. This comprehensive review discusses initiation, progression, action metabolites, highlighting their modulatory effects on types. Additionally, it examines involvement disease like rheumatoid arthritis, sclerosis, type 1 diabetes mellitus, autoimmune hepatitis, offering greater understanding for creating new therapies these ailments.

Language: Английский

Mini-review: research and progress of oxeiptosis in diseases DOI Creative Commons

Ke-Qian Chen,

Shuzhi Wang, Haibo Lei

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: June 20, 2024

Oxeiptosis is a novel cell death pathway that was introduced in 2018. As form of regulated death, it operates independently caspases and induced by ROS. Distinguished from other pathways such as apoptosis, necroptosis, pyroptosis, ferroptosis, oxeiptosis features unique damage causes pivotal genes, signaling (KEAP1/PGAM5/AIFM1). Emerging studies indicate plays significant role the progression various diseases its regulation could serve promising therapeutic target. However, precise molecular mechanisms underlying remain to be fully elucidated. In this mini-review, we systematically summarize latest developments oxeiptosis-related while detailing regulatory networks oxeiptosis. These insights offer foundation for deeper understanding

Language: Английский

Citations

6
Role of oxeiptosis in disease mechanisms and therapeutic opportunities DOI

K. Bhuvaneshwari,

Kannan Harithpriya, Kumar Ganesan

et al.

APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
Emerging therapeutic targets in systemic sclerosis DOI
Steven O’Reilly

Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 102(4), P. 465 - 478

Published: Feb. 22, 2024

Language: Английский

Citations

1
Metabolic Regulation of Inflammation: Exploring the Potential Benefits of Itaconate in Autoimmune Disorders DOI Open Access
Yin Luo,

Li‐Yan Jiang,

Zhe‐Zhen Liao

et al.

Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 14, 2024

Itaconic acid and its metabolites have demonstrated significant therapeutic potential in various immune diseases. Originating from the tricarboxylic cycle cells, itaconic can modulate responses, diminish inflammation, combat oxidative stress. Recent research has uncovered multiple mechanisms through which exerts effects, including inhibition of inflammatory cytokine production, activation anti-inflammatory pathways, modulation cell function by regulating cellular metabolism. Cellular actions are influenced metabolic such as inhibiting succinate dehydrogenase (SDH) activity or glycolysis, nuclear-factor-E2-related factor 2 (Nrf2), boosting defences against stress, suppression inflammation NF-κB pathway. This comprehensive review discusses initiation, progression, action metabolites, highlighting their modulatory effects on types. Additionally, it examines involvement disease like rheumatoid arthritis, sclerosis, type 1 diabetes mellitus, autoimmune hepatitis, offering greater understanding for creating new therapies these ailments.

Language: Английский

Citations

0