Connecting the dots: Involvement of methyltransferase-like 3, N6-methyladenosine modification, and ferroptosis in the pathogenesis of intracerebral hemorrhage pathogenesis DOI

Junxiang Mao,

Quantang Zhao,

Man Guo

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 382, P. 114948 - 114948

Published: Sept. 10, 2024

Language: Английский

Soot nanoparticles promote ferroptosis in dopaminergic neurons via alteration of m6A RNA methylation in Parkinson’s disease DOI

Jiezhu Feng,

Piao Zhang,

Kunlin Chen

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 473, P. 134691 - 134691

Published: May 22, 2024

Language: Английский

Citations

8
Methyltransferase-like enzyme 14 exacerbates retinal ganglion cell damage and diabetic retinopathy through N6-methyladenosine-dependent upregulation of pleckstrin homology domain and leucine rich repeat protein phosphatase 2 DOI
Li Chen, Ting Wei, Xuan Liu

et al.

Toxicology and Applied Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 117304 - 117304

Published: March 1, 2025

Language: Английский

Citations

0
IGF2BP2: an m6A reader that affects cellular function and disease progression DOI Creative Commons
Siyi Liu,

Shan Liao,

Junyu He

et al.

Cellular & Molecular Biology Letters, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 9, 2025

Abstract Insulin-like growth factor 2 messenger RNA (mRNA)-binding protein (IGF2BP2) is a widely studied N 6 -methyladenosine (m A) modification reader, primarily functioning to recognize and bind m A sites on the mRNA of downstream target genes, thereby enhancing their stability. Previous studies have suggested that IGF2BP2-m plays an essential role in cellular functions progression various diseases. In this review, we focus summarizing molecular mechanisms by which IGF2BP2 enhances stability genes through modification, regulating cell ferroptosis, epithelial–mesenchymal transition (EMT), stemness, angiogenesis, inflammatory responses, lipid metabolism, ultimately affecting disease progression. Additionally, update related research progress IGF2BP2. This article aims elucidate effects EMT, providing new perspective for comprehensive understanding relationship between such as ferroptosis well potential targeted therapy tumors other

Language: Английский

Citations

0
The m6A modification of ACSL4 mRNA sensitized esophageal squamous cell carcinoma to irradiation via accelerating ferroptosis DOI
Yingying Jin,

Shupei Pan,

Mincong Wang

et al.

Cell Biology International, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 16, 2024

Abstract Radioresistance is a major obstacle for the therapy of esophageal squamous cell carcinoma (ESCC) and lead to poor prognosis. Ferroptosis supposed be responsible radioresistance. However, ferroptosis‐induced radioresistance in ESCC its related regulatory mechanisms are not yet fully understood. In this study, human line corresponding cells were irradiated with 6 megavolts (MV) X‐ray. It was showed that irradiation led less ferroptosis radioresistant as compared parental cells, depicted by transmission electron microscopy, intracellular Fe 2+ iron contents, lipid peroxidation, expression COX2. The increase ASCL4 levels after radiotherapy smaller than cells. ACSL4 overexpression significantly enhanced ferroptosis. fold m A modification detected methylated RNA immunoprecipitation qRT‐PCR. METTL14 accelerated induced via upregulating mRNA. conclusions, ablation ESCC. METTL14‐mediated mRNA sensitized accelerating This study sheds new light on our understanding ESCC, provides potential strategies radiotherapy.

Language: Английский

Citations

1
Connecting the dots: Involvement of methyltransferase-like 3, N6-methyladenosine modification, and ferroptosis in the pathogenesis of intracerebral hemorrhage pathogenesis DOI

Junxiang Mao,

Quantang Zhao,

Man Guo

et al.

Experimental Neurology, Journal Year: 2024, Volume and Issue: 382, P. 114948 - 114948

Published: Sept. 10, 2024

Language: Английский

Citations

0