Meeting Regulatory Requirements of Natural Compounds in Skincare DOI
Sumanta Bhattacharya, Bhavneet Kaur Sachdev

Advances in chemical and materials engineering book series, Journal Year: 2024, Volume and Issue: unknown, P. 453 - 480

Published: Oct. 25, 2024

Cosmeceuticals with bioactive natural skincare products appeal to consumers seeking reliable cures. Pharmaceuticals and cosmetics benefit from these antioxidant, anti-inflammatory, antiaging agents. The components need clearance. One study demonstrated that cosmeceuticals may follow guidelines. framework covered ingredient sourcing, formulation, safety efficacy testing, laws. To ensure purity, efficacy, sustainability, the technique acquires trusted vendors quality control. Bioactive improve product performance synergy during formulation. Cosmetic compositions are tested for toxicology, dermatology, allergenicity. increase customer trust credibility, preclinical clinical studies have assessed component medicinal claims. FDA EU regulations involve substantial documentation, GMP compliance, tricky navigation. Safety, labeling boost market acceptance trust.

Language: Английский

Probiotics suppress LL37 generated rosacea-like skin inflammation by modulating the TLR2/MyD88/NF-κB signaling pathway DOI
Xinyue Qi,

Yiran Xiao,

Xinfeng Zhang

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(17), P. 8916 - 8934

Published: Jan. 1, 2024

Ligilactobacillus salivarius 23-006 and Lacticaseibacillus paracasei 23-008 ameliorated rosacea-like inflammation in mice through modulation of the gut microbiota TLR2/MyD88/NF-κB pathway.

Language: Английский

Citations

4
Obesity promotes immunotherapy efficacy by up-regulating the glycolytic-mediated histone lactacylation modification of CD8+ T cells DOI Creative Commons
Kaixuan Wang,

Dongmin Shi,

Xiaoli Shi

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

The response rate of immune checkpoint blockade (ICB) therapy for non-small-cell lung cancer (NSCLC) remains limited. Recent evidence suggests that obese patients are more likely to benefit from ICB therapy, however, the specific mechanism needs further research. In this study, we found anti-PD-1 was effective in NSCLC compared normal weight and verified mouse model. Further bioinformatics analysis indicated glycolytic metabolism markedly elevated patients. vitro co-culture experiment showed both increased glycolysis tumor cells external addition lactate promoted T cell PD-1 expression. And, upregulation related monocarboxylate transporter 1 (MCT1)-mediated transport subsequent lysine lactylation histones cells. Based on aforementioned data, our study contributes better application NSCLC.

Language: Английский

Citations

0
Oroxylin A alleviates pyroptosis and apoptosis in human corneal epithelial cells under hyperosmotic stress by activating the SIRT3-SOD2/HIF-1α pathway DOI
Xueqing Liu, Qiang Xu, Nan Jiang

et al.

Experimental Eye Research, Journal Year: 2025, Volume and Issue: 255, P. 110345 - 110345

Published: March 15, 2025

Language: Английский

Citations

0
Targeting TRIM40 signaling reduces esophagus cancer development: A mechanism involving in protection of oroxylin A DOI

Yanlei Ji,

Fengxiang Li,

Hui Zhang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112362 - 112362

Published: June 19, 2024

Language: Английский

Citations

1
Meeting Regulatory Requirements of Natural Compounds in Skincare DOI
Sumanta Bhattacharya, Bhavneet Kaur Sachdev

Advances in chemical and materials engineering book series, Journal Year: 2024, Volume and Issue: unknown, P. 453 - 480

Published: Oct. 25, 2024

Cosmeceuticals with bioactive natural skincare products appeal to consumers seeking reliable cures. Pharmaceuticals and cosmetics benefit from these antioxidant, anti-inflammatory, antiaging agents. The components need clearance. One study demonstrated that cosmeceuticals may follow guidelines. framework covered ingredient sourcing, formulation, safety efficacy testing, laws. To ensure purity, efficacy, sustainability, the technique acquires trusted vendors quality control. Bioactive improve product performance synergy during formulation. Cosmetic compositions are tested for toxicology, dermatology, allergenicity. increase customer trust credibility, preclinical clinical studies have assessed component medicinal claims. FDA EU regulations involve substantial documentation, GMP compliance, tricky navigation. Safety, labeling boost market acceptance trust.

Language: Английский

Citations

0