Mechanistic insights into the regression of atherosclerotic plaques

Frontiers in Physiology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 19, 2024

Atherosclerosis is a major contributor to cardiovascular diseases and mortality globally. The progression of atherosclerotic disease results in the expansion plaques development necrotic cores. Subsequent plaque rupture can lead thrombosis, occluding blood vessels, end-organ ischemia with consequential ischemic injury. Atherosclerotic are formed by accumulation lipid particles overloaded subendothelial layer vessels. Abnormally elevated levels impaired endothelial function initial factors leading atherosclerosis. atherosclerosis research has never been interrupted, previous view was that pathogenesis an irreversible chronic process. However, recent studies have found be halted when patients' reversed normal or lower. A large number indicates it inhibit lesions promote regression cores lowering levels, improving repair ability vascular cells, promoting reverse cholesterol transport foam cells enhancing macrophages phagocytize clear core plaque. This article reviews progress on mechanism regression. Our goal provide guidance for developing better therapeutic approaches reviewing analyzing latest scientific findings.

Language: Английский

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OTUB1 facilitates lipid accumulation in oxLDL‐induced THP‐1 macrophages by stabilizing scavenger receptor‐A

IUBMB Life, Journal Year: 2025, Volume and Issue: 77(3)

Published: March 1, 2025

Abstract The formation of foam cells triggered by excessive lipid accumulation within macrophages is a hallmark atherosclerosis development. Scavenger receptor‐A (SR‐A) key regulator uptake during oxidized low‐density lipoprotein (oxLDL)‐induced cell formation. Ubiquitination crucial post‐translational modification that regulates the stability and function targeted proteins, but whether SR‐A ubiquitinated how ubiquitination affects unknown. We found ovarian tumor domain protease 1 (OTUB1), deubiquitinase (DUBs) removes can stabilize in 293 T THP‐1 macrophages. Knockdown OTUB1 reduced protein level impaired oxLDL‐treated macrophages, which be rescued SR‐A. These data suggested OTUB1‐mediated stabilization may critical for

Language: Английский

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Advanced Detection and Therapeutic Monitoring of Atherosclerotic Plaque Using CD36-Targeted Lipid Core Probe

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(4), P. 444 - 444

Published: March 30, 2025

Background: Atherosclerotic diseases, including coronary heart disease and cerebrovascular disease, are leading causes of morbidity mortality worldwide. Atherosclerosis is a chronic vascular condition marked by the accumulation lipid plaque within arterial walls. These plaques can become unstable rupture, to thrombosis subsequent cardiovascular events. Therefore, early identification vulnerable critical for preventing such Objectives: This study aims develop novel imaging platform atherosclerotic designing molecular probe based on fluorescent molecules that target necrotic cores. The goal specifically detect high-risk plaque, enabling diagnosis intervention. Methods: Bioinformatic analysis immunofluorescence were used CD36 expression in human carotid plaque. CD36pep-ICG was synthesized using Fmoc solid-phase peptide method. A series experiments conducted characterize probe’s properties. To assess performance, concentration gradients tested FLI equipment. Ex vivo performed mice treatment models evaluate targeting ability effectiveness monitoring progression. Results: significantly elevated core compared distal regions. probe, designed lipids, successfully exhibited excellent fluorescence In animal models, demonstrated selectively accumulated precise detection. Moreover, monitor therapeutic efficacy anti-atherosclerotic drugs. Conclusions: developed this an effective tool specific offering approach treatment. Additionally, shows promise tracking effects drug, potentially advancing precision diseases.

Language: Английский

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Ertugliflozin attenuates atherosclerosis in nondiabetic ApoE−/− mice by upregulating ABCA1 and LDLR via the PPARγ/LXRα pathway

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Journal Year: 2025, Volume and Issue: 1871(7), P. 167927 - 167927

Published: May 24, 2025

Language: Английский

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