Anti-atopic dermatitis effect of fraxinellone via inhibiting IL-31 in vivo and in vitro

Heliyon, Journal Year: 2024, Volume and Issue: 10(15), P. e35391 - e35391

Published: July 29, 2024

Chronic recurrent itch and skin inflammation are prominent features of atopic dermatitis (AD), which is closely related to the immune response driven by T-helper type 2 (Th2) cells. The expression interleukin 31 (IL-31) positively correlated with severity dermatitis. Anti-IL-31 receptor α (IL-31RA) targeted drugs have been used treat AD, however, they expensive side effects. Fraxinellone (FRA) one main limonoid components in dried root bark

Language: Английский

Causal relationship between 41 inflammatory factors, circulating white blood cells, and pruritus: A 2-sample bidirectional Mendelian randomization study

Medicine, Journal Year: 2024, Volume and Issue: 103(50), P. e40894 - e40894

Published: Dec. 13, 2024

The influence of circulating white blood cells and inflammatory factors on pruritus is gradually recognized by the public, but specific causal relationship still unknown. In this study, we included cytokine profiles from 8293 healthy subjects, genetic data various ethnic ancestry backgrounds, including 746,667 individuals, 1370 patients European descent with for a bidirectional 2-sample Mendelian randomization (MR) analysis. We employed several robust statistical methods, inverse variance weighted, weighted median, MR-Egger method. further refined our analysis through meticulous sensitivity assessment using leave-one-out strategy, evaluated heterogeneity findings Cochran’s Q test, addressed potential pleiotropic effects intercept test. Ultimately, reverse MR was conducted to assess causation. Genetic prediction indicate positive correlation between eosinophil cell count risk developing (odds ratio [OR] = 1.31, 95% confidence interval [CI] 1.09–1.55, P .003). Furthermore, elevated levels stromal-cell-derived factor 1 alpha (OR 1.80, CI: 1.15–2.77, .009), monokine induced gamma interferon 1.23, 1.04–1.46, .015), cutaneous T-cell-attracting chemokine 1.24, 1.01–1.53, .043) are all associated an increased occurrence, respectively. No evidence horizontal pleiotropy or observed among variants ( > .05), confirmed stability robustness association. demonstrated absence causality. Our research delineates links count, alpha, interferon, levels, susceptibility. These insights may present promising avenues enhancing management therapeutic strategies suffering pruritus.

Language: Английский

Scratching the Surface: A Paraneoplastic Pruritus Phenomenon in a Mediastinal Mass

SKIN The Journal of Cutaneous Medicine, Journal Year: 2024, Volume and Issue: 8(3), P. 1609 - 1611

Published: May 13, 2024

Language: Английский