p38α deficiency ameliorates psoriasis development by downregulating STAT3-mediated keratinocyte proliferation and cytokine production DOI Creative Commons
Tingting Zheng,

Jiaqi Deng,

Jiahong Wen

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Aug. 15, 2024

Psoriasis is characterized by keratinocyte (KC) hyperproliferation and inflammatory cell infiltration, but the mechanisms remain unclear. In an imiquimod-induced mouse psoriasiform model, p38 activity significantly elevated in KCs p38α specific deletion ameliorates skin inflammation. signaling promotes KC proliferation psoriasis-related proinflammatory gene expression during psoriasis development. Mechanistically, enhances production of cytokines chemokines activating STAT3. While does not affect IL-23 IL-17, it substantially amplifies IL-23/IL-17 pathogenic axis psoriasis. The therapeutic effect IL-17 neutralization associated with decreased STAT3 activities targeting p38α-STAT3 severity As also highly activates KCs, our findings reveal a sustained circuit important for development, highlighting as target treatment. STAT3, further axis.

Language: Английский

Ergosterone ameliorates RRR-induced spleen deficiency by gut microbiota-gut metabolites and P38MAPK signaling pathway DOI Creative Commons
Ying Liu, Haiying Bao

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: March 5, 2025

Spleen deficiency is an important immune and digestive system change. Ergosterone (ER) bioactive steroid; however, to date, no relevant studies have explored its potential efficacy in treating spleen deficiency. The aim of the present study was investigate therapeutic effects mechanism action ER on syndrome induced by Rhei Radix et Rhizoma (RRR). RRR used induce development a rat model observe changes body weight pathological organ tissues. Additionally, levels factors gastrointestinal hormones were measured, as well expression intestinal tight junction proteins P38MAPK signaling pathway. Changes microbiota metabolites effect RRR-induced evaluated. notably alleviated symptoms rats offered protection against damage. can increase immunoglobulins, inhibits inflammatory factors, improve hormone disorders, protect mucosa, repair barrier ER-treated group exhibited substantial upregulation claudin occludin mRNA protein colonic tissue. inhibited P38MAPKsignaling pathway, thereby improving rats. also influences metabolic pathways digestion absorption, biosynthesis unsaturated fatty acids, arachidonic acid metabolism. In addition, regulate enhance composition flora with deficiency, diversity dominant flora, inhibit proliferation harmful bacteria. treat enhancing function, repairing barrier, regulating metabolites.

Language: Английский

Citations

0
Oleoylethanolamide ameliorates collagen-induced rheumatoid arthritis via activation of GPR119 DOI
Jung Eun Lee, Dong‐Soon Im

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114660 - 114660

Published: April 14, 2025

Language: Английский

Citations

0
Integrating network pharmacology and experimental validation to advance psoriasis treatment: Multi-target mechanistic elucidation of medicinal herbs and natural compounds DOI
Hee-Geun Jo, Jihye Seo, Boyun Jang

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103836 - 103836

Published: May 1, 2025

Language: Английский

Citations

0
p38α deficiency ameliorates psoriasis development by downregulating STAT3-mediated keratinocyte proliferation and cytokine production DOI Creative Commons
Tingting Zheng,

Jiaqi Deng,

Jiahong Wen

et al.

Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)

Published: Aug. 15, 2024

Psoriasis is characterized by keratinocyte (KC) hyperproliferation and inflammatory cell infiltration, but the mechanisms remain unclear. In an imiquimod-induced mouse psoriasiform model, p38 activity significantly elevated in KCs p38α specific deletion ameliorates skin inflammation. signaling promotes KC proliferation psoriasis-related proinflammatory gene expression during psoriasis development. Mechanistically, enhances production of cytokines chemokines activating STAT3. While does not affect IL-23 IL-17, it substantially amplifies IL-23/IL-17 pathogenic axis psoriasis. The therapeutic effect IL-17 neutralization associated with decreased STAT3 activities targeting p38α-STAT3 severity As also highly activates KCs, our findings reveal a sustained circuit important for development, highlighting as target treatment. STAT3, further axis.

Language: Английский

Citations

0