On the design of cell membrane-coated nanoparticles to treat inflammatory conditions DOI
Andreia Marinho, Salette Reis, Cláudia Nunes

et al.

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Cell membrane-coated nanoparticles (CMCNPs) offer targeted and effective treatment for chronic inflammatory conditions by mimicking natural cell interactions enhancing immune evasion.

Language: Английский

A Spleen‐Targeted Tolerogenic mRNA‐LNPs Vaccine for the Treatment of Experimental Asthma DOI Creative Commons
Fazhan Wang,

Jia Lou,

Xiaohan Lou

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Lipid nanoparticles (LNPs)-based mRNA vaccines have witnessed their great advantages in the fight against infectious diseases. However, pro-inflammatory properties of mRNA-LNPs may hinder induction antigen-specific tolerogenic immune responses. Here, it is demonstrated that stearic acid-doped LNPs co-loaded with nucleoside-modified and celastrol selectively target spleen, convert adjuvanticity promote a rather than immunogenic DCs phenotype. Furthermore, vaccine also invokes generation regulatory T cells (Tregs) spleen migration induced Tregs to lung. In mouse model allergic asthma, immunization significantly alleviated symptom induction, reducing eosinophilic granulocyte accumulation mucus secretion. conclusion, this spleen-targeted platform induces responses, offering promise for development therapeutics asthma other conditions requiring tolerance modulation.

Language: Английский

Citations

1
A comprehensive review of natural products in rheumatoid arthritis: therapeutic potential and mechanisms DOI Creative Commons

Han Yu-li,

Shujing Chen,

Changqing Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 8, 2025

Rheumatoid arthritis (RA) is a classic autoimmune disease caused by combination of genetic and environmental factors. The multiple comprehensive pathologies involving the whole body’s immune system local organs tissues make it challenging to control or cure them clinically. Fortunately, there are increasing reports that non-toxic low-toxicity natural products their derivatives (NP&TDs) have positive therapeutic effects on RA. This review focuses potential mechanisms NP&TDs against RA aims provide constructive information for developing rational clinical therapies. Active components can play palliative roles in through biological mechanisms. These primarily involve immunosuppressive, anti-inflammatory, autophagic, apoptotic pathways. Multiple targets- receptor-coupled signal transduction directly indirectly modulates nuclear transcription factors NF-κB, NFATc1, STAT3, HIF-1α, which turn regulate production several downstream pro-inflammatory cytokines, chemokines, immunocytes maturation differentiation, complexes, proliferation, apoptosis regulatory genes. Among these NP&TDs, tripterygium-type ingredients, artemisinin-type paeony-type ingredients been reported be mainstay treating Mechanistically, immunosuppression anti-inflammation still primary Nevertheless, direct binding targets pharmacodynamic require further in-depth studies.

Language: Английский

Citations

0
Nanometer preparation of natural bioactive compounds for treatment of rheumatoid arthritis DOI Creative Commons

Junping Zhu,

Xiang Qin, Qi Li

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101341 - 101341

Published: May 1, 2025

Language: Английский

Citations

0
On the design of cell membrane-coated nanoparticles to treat inflammatory conditions DOI
Andreia Marinho, Salette Reis, Cláudia Nunes

et al.

Nanoscale Horizons, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Cell membrane-coated nanoparticles (CMCNPs) offer targeted and effective treatment for chronic inflammatory conditions by mimicking natural cell interactions enhancing immune evasion.

Language: Английский

Citations

1