p21‐Activated Kinase 1 (Pak1) as an Element in Functional and Dysfunctional Interplay Among the Myocardium, Adipose Tissue, and Pancreatic Beta Cells

Comprehensive physiology, Journal Year: 2025, Volume and Issue: 15(2)

Published: March 10, 2025

This review focuses on p21-activated kinase 1 (Pak1), a multifunctional, highly conserved enzyme that regulates multiple downstream effectors present in many tissues. Upstream signaling via Ras-related small G-proteins, Cdc42/Rac1 promotes the activity of Pak1. Our hypothesis is this cascade an important element communication among myocardium, adipose tissue, and pancreatic β-cells. Evidence indicates shared property these tissues structure/function stability requires homeostatic Pak1 activity. Increases or decreases may promote dysfunction increase susceptibility to stressors. increased levels be protective provides support for efforts develop therapeutic approaches activating with potential use prevalent disorders associated obesity, diabetes, myocardial dysfunction. On other hand, since cancer progression, there has been significant effort inhibitors. These opposing highlight need deep understanding relation development effective selective therapies minimal absent off-target effects.

Language: Английский

FTY720 alleviates HBV-mediated inflammatory liver injury through a dual role of inhibiting lymphocyte trafficking and viral replication

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 153, P. 114495 - 114495

Published: March 23, 2025

Language: Английский