Unraveling TRPV1’s Role in Cancer: Expression, Modulation, and Therapeutic Opportunities with Capsaicin DOI Creative Commons

Subramanyam Reddy Chinreddy,

Nicole Tendayi Mashozhera,

Badraldeen Rashrash

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4729 - 4729

Published: Oct. 7, 2024

Cancer is a global health challenge with rising incidence and mortality rates, posing significant concerns. The World Health Organization reports cancer as leading cause of death worldwide, contributing to nearly one in six deaths. pathogenesis involves disruptions cellular signaling pathways, resulting uncontrolled cell growth metastasis. Among emerging players biology, Transient Receptor Potential (TRP) channels, notably TRPV1, have garnered attention due their altered expression cells roles tumorigenesis progression. also known the capsaicin receptor, pivotal pain mediation, offering promise therapeutic target. Activation TRPV1 triggers calcium influx affects linked death. Additionally, implicated cancer-induced chemo-sensitivity, upregulation observed sensory neurons innervating oral cancers. Also, when capsaicin, compound from chili peppers, interacts it elicits "hot" sensation influences processes through influx. Understanding TRPV1's multifaceted may lead novel strategies for managing cancer-related symptoms improving patient outcomes. current review elucidates comprehensive role therapy, particularly channel, highlighting its effects various via different pathways discussing limitations.

Language: Английский

Kinase Inhibitors and Kinase-Targeted Cancer Therapies: Recent Advances and Future Perspectives DOI Open Access
Jiahao Li, Gong Chen, Haiting Zhou

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5489 - 5489

Published: May 17, 2024

Over 120 small-molecule kinase inhibitors (SMKIs) have been approved worldwide for treating various diseases, with nearly 70 FDA approvals specifically cancer treatment, focusing on targets like the epidermal growth factor receptor (EGFR) family. Kinase-targeted strategies encompass monoclonal antibodies and their derivatives, such as nanobodies peptides, along innovative approaches use of degraders protein interaction inhibitors, which recently demonstrated clinical progress potential in overcoming resistance. Nevertheless, kinase-targeted encounter significant hurdles, including drug resistance, greatly impacts benefits patients, well concerning toxicity when combined immunotherapy, restricts full utilization current treatment modalities. Despite these challenges, development remains highly promising. The extensively studied tyrosine family has 70% its stages development, while 30% inadequately explored. Computational technologies play a vital role accelerating novel repurposing existing drugs. Recent FDA-approved SMKIs underscore importance blood-brain barrier permeability long-term patient benefits. This review provides comprehensive summary recent based mechanisms action targets. We summarize latest developments new explore emerging inhibition from perspective. Lastly, we outline obstacles future prospects inhibition.

Language: Английский

Citations

21
Targeting acquired resistance via promoting stemness of EGFR mutant mitigates lung adenocarcinomas progression: Intervention by harpagoside (Xuandanqingjin decoction) DOI Creative Commons
Jiamao Lin, Lei Liu, Shenglin Ma

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 127, P. 106729 - 106729

Published: March 20, 2025

Language: Английский

Citations

0
JAK inhibitors as a promising therapy for immune-mediated photodermatoses DOI
Mohammad Malekan, Saeid Taghiloo, Armaghan Kazeminejad

et al.

Drug Discovery Today, Journal Year: 2025, Volume and Issue: unknown, P. 104344 - 104344

Published: March 1, 2025

Language: Английский

Citations

0
STAT3 Signaling Pathway in Health and Disease DOI Creative Commons
Md Abdus Samad, Iftikhar Ahmad, A. M. Mahedi Hasan

et al.

MedComm, Journal Year: 2025, Volume and Issue: 6(4)

Published: March 30, 2025

ABSTRACT Signal transducer and activator of transcription 3 (STAT3) is a critical factor involved in multiple physiological pathological processes. While STAT3 plays an essential role homeostasis, its persistent activation has been implicated the pathogenesis various diseases, particularly cancer, bone‐related autoimmune disorders, inflammatory cardiovascular neurodegenerative conditions. The interleukin‐6/Janus kinase (JAK)/STAT3 signaling axis central to activation, influencing tumor microenvironment remodeling, angiogenesis, immune evasion, therapy resistance. Despite extensive research, precise mechanisms underlying dysregulated disease progression remain incompletely understood, no United States Food Drug Administration (USFDA)‐approved direct inhibitors currently exist. This review provides comprehensive evaluation STAT3's health disease, emphasizing involvement cancer stem cell maintenance, metastasis, inflammation, drug We systematically discuss therapeutic strategies, including JAK (tofacitinib, ruxolitinib), Src Homology 2 domain (S3I‐201, STATTIC), antisense oligonucleotides (AZD9150), nanomedicine‐based delivery systems, which enhance specificity bioavailability while reducing toxicity. By integrating molecular mechanisms, pathology, emerging interventions, this fills knowledge gap STAT3‐targeted therapy. Our insights into crosstalk, epigenetic regulation, resistance offer foundation for developing next‐generation with greater clinical efficacy translational potential.

Language: Английский

Citations

0
Natural Alkaloids Modulating Macrophage Polarization: Innovative Therapeutic Strategies for Inflammatory, Cardiovascular, and Cancerous Diseases DOI
Jing Lü, Minghao Yin, Yixuan Song

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156709 - 156709

Published: April 1, 2025

Language: Английский

Citations

0
The pharmacological and therapeutic versatility of Allium species: a comprehensive exploration of bioactive constituents and biological activities DOI Creative Commons
Neeta Singh,

Anjali Gusain,

Manisha Nigam

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 7(4)

Published: April 14, 2025

Language: Английский

Citations

0
Role of signaling pathways in endometrial cancer DOI
Nikita Balhara, Ritu Yadav, Meenakshi Chauhan

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: April 21, 2025

Language: Английский

Citations

0
Interlinking pathways: a narrative review on the role of IL-6 in cancer and atherosclerosis DOI Open Access
Riccardo Cau, Luca Saba

Cardiovascular Diagnosis and Therapy, Journal Year: 2024, Volume and Issue: 14(6), P. 1186 - 1201

Published: Nov. 21, 2024

Interleukin-6 (IL-6) plays multifaceted roles in cancer and atherosclerosis. Initially recognized for its role immune response inflammation, IL-6 promotes tumor progression via the JAK-STAT MAP kinase pathways is associated with poor prognoses. In atherosclerosis, contributes to endothelial dysfunction plaque formation. This review highlights shared inflammatory mechanisms of both diseases explores regulatory dynamics signaling, including gene polymorphisms epigenetic modifications. Google Scholar, Scopus, PubMed were searched English-language articles on those reporting pathogenic atherosclerosis from their inception through June 2024. The investigation into IL-6's reveals intricate interconnected nature processes chronic diseases. conditions underscores centrality disease pathology, particularly involvement modulation, cellular proliferation. commonality as a key player linking these seemingly distinct Given mechanism this narrative concludes by emphasizing therapeutic potential modulating treating It advocates personalized treatment strategies that combine targeted therapies lifestyle holistic approach considered crucial effective management, given diverse complex widespread conditions.

Language: Английский

Citations

3
Hepatoprotective activity of Taraxacum officinale extract against CCl4-induced Liver injury in rats DOI

Nesrein S. Salim,

Mohamed F. Abo El‐Maati, Sameh A. Abdelnour

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106708 - 106708

Published: April 1, 2025

Language: Английский

Citations

0
Rewiring the T cell-suppressive cytokine landscape of the tumor microenvironment: a new frontier for precision anti-cancer therapy DOI Creative Commons

Ludovica Lopresti,

Vanessa Tatangelo, Cosima T. Baldari

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 30, 2024

T lymphocytes that infiltrate the tumor microenvironment (TME) often fail to function as effective anti-cancer agents. Within TME, cell-to-cell inhibitory interactions play significant roles in dampening their anti-tumor activities. Recent studies have revealed soluble factors released TME by immune and non-immune cells, well cells themselves, contribute exacerbation of cell exhaustion. Our understanding cytokine landscape interrelationships, impact on cancer development is still at its early stages. In this review, we aim shed light Interleukin (IL) -6, IL-9, IL-10, a small group JAK/STAT signaling-dependent cytokines harboring cell-suppressive effects summarize mechanisms action. Additionally, will explore how advancements scientific research can help us overcoming obstacles posed suppress tumors, with ultimate objective stimulating further investigations for novel therapeutic strategies counteract tumor-promoting

Language: Английский

Citations

2