The advancement of targeted regulation of hepatic stellate cells using Traditional chinese medicine for the treatment of liver fibrosis

Journal of Ethnopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 119298 - 119298

Published: Jan. 1, 2025

Language: Английский

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Quercetin-primed BMSC-derived extracellular vesicles ameliorate chronic liver damage through miR-136-5p and GNAS/STAT3 signaling pathways

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113162 - 113162

Published: Sept. 27, 2024

Language: Английский

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Apolipoprotein A1-encoding recombinant adenovirus remodels cholesterol metabolism in tumors and the tumor microenvironment to inhibit hepatocellular carcinoma

Translational research, Journal Year: 2024, Volume and Issue: 275, P. 18 - 31

Published: Nov. 10, 2024

Hepatocellular carcinoma (HCC) is a prevalent malignant tumor requiring effective treatments. Oncolytic viruses induce anti-tumor responses but have limited efficacy. Apolipoprotein A1 (ApoA1) inhibits inflammation, modulates immunity, and promotes anti-oxidation. This study aims to construct an oncolytic adenovirus (Ad5)-ApoA1 for superior effects. We analyzed ApoA1 expression in tumors its prognostic significance using public databases. Subsequently, we engineered recombinant Ad5-ApoA1 assessed replication efficacy vitro nude mice. The impact of on the microenvironment HCC was evaluated through flow cytometry, transcriptome sequencing, single-cell other methodologies. Additionally, mechanisms immune modulation by were explored. down-regulated with progression significantly positively correlated prognosis patients. exhibited robust activity showed no therapeutic effect However, it inhibited growth prolonged survival period both healthy-immune humanized immune-reconstituted NCG Furthermore, promoted IFN-γ GzmB CD8

Language: Английский

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Interpretable Machine Learning reveals the Role of PANoptosis in the Diagnosis and Subtyping of NAFLD

Immunobiology, Journal Year: 2025, Volume and Issue: 230(3), P. 152909 - 152909

Published: April 26, 2025

Language: Английский

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Human Umbilical Cord-Derived Mesenchymal Stem Cells Attenuate Liver Fibrosis by Inhibiting Hepatocyte Ferroptosis Through Mitochondrial Transfer

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: 231, P. 163 - 177

Published: Feb. 27, 2025

Language: Английский

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The Impact of Semaglutide on Liver Fat Assessed by Serial Cardiac CT scans in Patients with Type 2 Diabetes: Results from STOP Trial.

Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 104036 - 104036

Published: April 1, 2025

Language: Английский

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Tao-Hong-Si-Wu-Tang improves thioacetamide-induced liver fibrosis by reversing ACSL4-mediated lipid accumulation and promoting mitophagy

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 333, P. 118456 - 118456

Published: June 13, 2024

Language: Английский

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Guizhi Fuling Wan attenuates tetrachloromethane-induced hepatic fibrosis in rats via PTEN/AKT/mTOR signaling pathway

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 334, P. 118593 - 118593

Published: July 19, 2024

Language: Английский

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Eriocitrin ameliorates hepatic fibrosis and inflammation: The involvement of PPARα-mediated NLRP1/NLRC4 inflammasome signaling cascades

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 119119 - 119119

Published: Nov. 1, 2024

Language: Английский

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