Understanding the impact of valproate on male fertility: insights from preclinical and clinical meta-analysis

BMC Pharmacology and Toxicology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Sept. 27, 2024

Language: Английский

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Quercetin attenuates DEHP-induced pyroptosis and programmed necrosis in chicken duodenum through regulation of the TLR4/MyD88/NF-κB pathway

Environmental Pollution, Journal Year: 2025, Volume and Issue: 372, P. 126016 - 126016

Published: March 6, 2025

Language: Английский

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Pre-clinical evidence for mitochondria as a therapeutic target for luteolin: a mechanistic view

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111492 - 111492

Published: March 1, 2025

Language: Английский

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Dimethyl Fumarate Protects Diabetes‐Induced Testicular Toxicity in Rats: Investigations on Nrf‐2/HO‐1 and β‐Catenin/OCT‐4 Signalling Pathways

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(4)

Published: March 27, 2025

Type 1 Diabetes Mellitus (T1DM) is associated with the destruction of insulin-producing β-cells and characterized by prolonged hyperglycemia. This can increase oxidative stress which eventually damages male reproductive system, disturbs production testosterone, alters semen quality histological architecture, increases testicular apoptosis. Dimethyl Fumarate (DMF) an Nrf-2 activator that has been explored as possible protective agent in several preclinical studies, although its exact role germ-cell toxicity still not well-known. In present study, attempt made to elucidate DMF Sprague-Dawley (SD) rats. Animals having fasting blood glucose >250 mg/dl after treatment Streptozotocin (STZ; 55 mg/kg, i.p) were considered diabetic. Three doses (12.5, 25, 50 mg/kg) administered diabetic animals for 4 consecutive weeks. The damage was evaluating organ index, biochemical parameters, sperm-related indices, DNA strand breaks, expression different proteins. results revealed ameliorated diabetes-induced decreasing apoptosis, increasing testosterone production, upregulating expressions Nrf-2, HO-1, IL-10, β-Catenin, OCT-4, 3β-HSD, Bcl-2 downregulating NF-κB, Bax. finding suggests a effect against SD rat.

Language: Английский

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Quercetin Protects against Silicon dioxide Particles-induced spleen ZBP1-Mediated PANoptosis by regulating the Nrf2/Drp1/mtDNA axis

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113546 - 113546

Published: Nov. 2, 2024

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