Fatal risk factors and the efficacy of glucocorticoid therapy in severe fever with thrombocytopenia syndrome: a multicenter retrospective cohort study DOI Creative Commons
Fang Zhong, Shiyu Zhang,

Chengxi Zheng

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: May 8, 2025

Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease characterized by rapid progression and high mortality. Glucocorticoids (GCs) can be used as anti-inflammatory agents for SFTS, but no standardized protocols have been proposed. Methods A total of 901 patients SFTS diagnosed at two hospitals between July 2017 October 2023 were included in this retrospective cohort study. Univariate multivariate logistic regression performed along LASSO to identify independent risk factors fatal outcomes further develop mortality prediction model. nomogram was visualize the predictive ROC curves, calibration DCA curves conducted assess model accuracy clinical applicability. The efficacy GC assessed using survival analyses, subgroup analyses effects different regimens on hospital-acquired infections (HAI) performed. Propensity score matching (PSM) control confounding factors. Results Older age (age > 69 years), consciousness disturbance, decreased monocyte counts, prolonged activated partial thromboplastin time (APTT), viral load identified strong predictors SFTS. Patients classified into mild severe groups according scores calculated (cut-off value = 121.43). Survival showed that GCs treatment may reduce (p 0.004). Further indicated relatively doses early increase [OR 2.292 (1.071, 5.066); OR 3.693 (1.710, 8.345) respectively]. associated elevated HAI both 0.024; p 0.015, respectively). Initiation therapy a low level aspartate aminotransferase (AST < 189.75 U/L) reduced before after PSM (p<0.001; 0.004, Conclusions new based five effectively predicts prognosis those AST levels might benefit from while should caution.

Language: Английский

Development and Multi-center validation of a machine learning Model for advanced colorectal neoplasms screening DOI
Mingqing Zhang, Yongdan Zhang, Lizhong Zhao

et al.

Computers in Biology and Medicine, Journal Year: 2025, Volume and Issue: 190, P. 110066 - 110066

Published: March 30, 2025

Language: Английский

Citations

0
Fatal risk factors and the efficacy of glucocorticoid therapy in severe fever with thrombocytopenia syndrome: a multicenter retrospective cohort study DOI Creative Commons
Fang Zhong, Shiyu Zhang,

Chengxi Zheng

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: May 8, 2025

Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease characterized by rapid progression and high mortality. Glucocorticoids (GCs) can be used as anti-inflammatory agents for SFTS, but no standardized protocols have been proposed. Methods A total of 901 patients SFTS diagnosed at two hospitals between July 2017 October 2023 were included in this retrospective cohort study. Univariate multivariate logistic regression performed along LASSO to identify independent risk factors fatal outcomes further develop mortality prediction model. nomogram was visualize the predictive ROC curves, calibration DCA curves conducted assess model accuracy clinical applicability. The efficacy GC assessed using survival analyses, subgroup analyses effects different regimens on hospital-acquired infections (HAI) performed. Propensity score matching (PSM) control confounding factors. Results Older age (age > 69 years), consciousness disturbance, decreased monocyte counts, prolonged activated partial thromboplastin time (APTT), viral load identified strong predictors SFTS. Patients classified into mild severe groups according scores calculated (cut-off value = 121.43). Survival showed that GCs treatment may reduce (p 0.004). Further indicated relatively doses early increase [OR 2.292 (1.071, 5.066); OR 3.693 (1.710, 8.345) respectively]. associated elevated HAI both 0.024; p 0.015, respectively). Initiation therapy a low level aspartate aminotransferase (AST < 189.75 U/L) reduced before after PSM (p<0.001; 0.004, Conclusions new based five effectively predicts prognosis those AST levels might benefit from while should caution.

Language: Английский

Citations

0