S100A9 regulates M1 macrophage polarization and exacerbates steatotic liver ischemia-reperfusion injury DOI
Mingwei Sheng, Weihua Liu,

Zhangjiu Lu

et al.

Transplant Immunology, Journal Year: 2024, Volume and Issue: 87, P. 102134 - 102134

Published: Oct. 4, 2024

Language: Английский

A tri-compound formula comprising ginsenoside Rg1, tetrandrine and icariin alleviates atopic dermatitis symptoms in a mouse model DOI
Ying Wu,

Xiaoqi Wang,

Jia‐Ying Wu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156737 - 156737

Published: April 1, 2025

Language: Английский

Citations

0
Protective Effects of Albiflorin on Acetaminophen-Induced Hepatotoxicity: Regulation of Blood–Biliary Barrier Integrity by ATF3 DOI
Musen Lin, Yue Wang, Zhao Yan

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156722 - 156722

Published: April 1, 2025

Language: Английский

Citations

0
Aloperine Ameliorates Acetaminophen‐Induced Acute Liver Injury through HMGB1/TLR4/NF‐κB and NLRP3/Inflammasome Pathway DOI Creative Commons
Hui Chen, Shu Wang, Qiuyue Chen

et al.

Mediators of Inflammation, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Purpose . Aloperine (ALO), an alkaloid isolated from Sophora alopecuroides L., possesses multiple pharmacological activities and holds a promise potential for the treatment of various clinical conditions, including skin hypersensitivity, cancer, inflammatory disorders. The purpose this study was to investigate role ALO in acetaminophen (N‐acetyl‐para‐aminophenol (APAP))‐induced acute liver injury its underlying mechanisms. Materials Methods An animal model induced by intraperitoneal injection APAP (150 mg/kg). Prior injection, (40 mg/kg) administered daily 7 consecutive days. Serum alanine aminotransferase, aspartate lactate dehydrogenase levels were then measured using automated chemical analyzer. Histopathological changes evaluated hematoxylin eosin staining. Oxidative stress detecting superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA). Pro‐inflammatory cytokines detected serum tissues ELISA quantitative real‐time polymerase chain reaction (q‐PCR). expression members HMGB1/TLR4/NF‐ κ B signaling pathway NLRP3 inflammasome determined Western blot and/or q‐PCR. In addition, location NLRP3, cleaved caspase‐1, high‐mobility group box 1 (HMGB1), phosphorylated p65 (p‐p65) immunofluorescence. Results Pretreatment with significantly protected mice APAP‐induced injury, decreased MDA content, increased GSH SOD activities. Furthermore, pretreatment reduced release pro‐inflammatory (IL‐1 β TNF‐ α ) NLRP3. also inhibited activation pathway. Conclusion Taken together, can ameliorate inhibiting oxidative stress, inflammation B, NLRP3/inflammasome

Language: Английский

Citations

3
Epimedii Folium flavonoids: A double-edged sword effect on the liver, a dual exploration of efficacy and toxicity DOI Creative Commons

Meijun Yue,

Yanlu Liu,

Xiaoyu Feng

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101269 - 101269

Published: March 1, 2025

Language: Английский

Citations

0
S100A9 regulates M1 macrophage polarization and exacerbates steatotic liver ischemia-reperfusion injury DOI
Mingwei Sheng, Weihua Liu,

Zhangjiu Lu

et al.

Transplant Immunology, Journal Year: 2024, Volume and Issue: 87, P. 102134 - 102134

Published: Oct. 4, 2024

Language: Английский

Citations

0