Histone modifications in hypoxic ischemic encephalopathy: Implications for therapeutic interventions DOI

Yichen Ji,

Ye Tian, Huiyi Zhang

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122983 - 122983

Published: Aug. 13, 2024

Language: Английский

Novel Insights into Neuroinflammatory Mechanisms in Traumatic Brain Injury: Focus on Pattern Recognition Receptors as Therapeutic Targets DOI

Harapriya Baral,

Ravinder K. Kaundal

Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

1
Punicalagin inhibits excessive autophagy and improves cerebral function in neonatal rats with hypoxia-ischemia brain injury by regulating Akt-FOXO4 DOI Creative Commons
Mingyue Shen,

Junhong Lü,

Caiyan Li

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 136, P. 156330 - 156330

Published: Jan. 1, 2025

Neonatal hypoxic-ischemic encephalopathy (HIE) has a high incidence and mortality rate, representing significant patient burden. Therefore, treatment strategies that work synergistically with hypothermic therapies are urgently required. Punicalagin (PUN) is natural safe polyphenol anti-inflammatory functions whose excellent water solubility safety make it an advantageous perinatal medication. However, its underlying mechanisms of action in HIE remain unclear. This study investigated the role associated mechanism PUN HIE. We used Rice Vannucci method to construct vivo model rats, from which we extracted primary cortical neurons vitro oxygen glucose deprivation/reoxygenation (OGD/R) model. The were using transcriptome sequencing, laser speckle contrast imaging, 2,3,5-triphenyltetrazolium chloride-staining, Morris maze test, western blotting, qPCR, immunofluorescence, histochemistry. rats demonstrated excessive autophagy inflammation. reduced brain tissue damage neuronal apoptosis, improved cerebral blood flow perfusion, learning, cognitive abilities. attenuated autophagic overexpression following inhibited AKT-FOXO4 (forkhead box O4) signaling pathway. neuroprotective effects by AKT pathway inhibitor 3-MA. Furthermore, was ineffective siFOXO4 rats. significantly reduces infarction, neuroinflammation, caused HIE, thereby exerting short- long-term effects. Mechanistically, effect mediated activation may be potential therapy for

Language: Английский

Citations

0
Quercetin attenuates DEHP-induced pyroptosis and programmed necrosis in chicken duodenum through regulation of the TLR4/MyD88/NF-κB pathway DOI

Ruirui Xie,

Tong Xu, Yilin Yin

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: 372, P. 126016 - 126016

Published: March 6, 2025

Language: Английский

Citations

0
Natural retrochalcones: rare compounds with diverse biological activities DOI Creative Commons
Milan Malaník

Phytochemistry Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

0
AIM2 exacerbates hypoxic-ischemic brain damage in neonatal rats via promoting neuronal pyroptosis DOI Creative Commons
Qianqian Li, Zhou Wang,

Fengli Li

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: 224, P. 111305 - 111305

Published: March 16, 2025

Pyroptosis has been reported to play a pathogenic role in neonatal hypoxic-ischemic brain damage (HIBD). Absence melanoma 2 (AIM2) is an inflammasome involved pyroptosis. This study aimed investigate the of AIM2 hypoxic-ischemia (HI)-induced pyroptosis and rat HIBD model. In vivo, we injected lentivirus that overexpressed or knocked down into lateral ventricle rats within 24h after birth prepared 7-day Sprague Dawley (SD) vitro, transfected lentiviruses overexpressing knocking cultured primary neurons established oxygen/glucose deprivation/reoxygenation (OGD/R) 2,3,5-triphenyltetrazolium chloride (TTC) staining was used determine infarct size. Hematoxylin eosin Nissl were evaluate morphological changes damaged brain. Cell Counting Kit-8 (CCK-8) lactate dehydrogenase (LDH) assays cell viability toxicity. observed using transmission electron microscopy. expression significantly increased HI-induced cortex rats. Lentivirus-mediated overexpression aggravates injury OGD/R-induced neuronal vivo vitro. The lentivirus-mediated knockdown reversed these adverse effects. addition, whereas suppressed via AIM2/Caspase-1/GSDMD pathway. These findings show upregulation activates plays HIBD.

Language: Английский

Citations

0
Exploring NLRP3 Inhibition as a Key Modulator in Neonatal Hypoxic-Ischemic Brain Injury DOI
Khiany Mathias, Richard Simon Machado,

Taise Cardoso

et al.

NeuroMolecular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: April 8, 2025

Language: Английский

Citations

0
Licochalcone A loaded multifunctional chitosan hyaluronic acid hydrogel with antibacterial and inflammatory regulating effects to promote wound healing DOI
Zhiquan Hou, Yahong Wang, Siqi Chen

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137458 - 137458

Published: Nov. 9, 2024

Language: Английский

Citations

3
Histone modifications in hypoxic ischemic encephalopathy: Implications for therapeutic interventions DOI

Yichen Ji,

Ye Tian, Huiyi Zhang

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 354, P. 122983 - 122983

Published: Aug. 13, 2024

Language: Английский

Citations

1