Neuroprotective effect of empagliflozin against doxorubicin-induced chemobrain in rats: interplay between SIRT-1/MuRF-1/PARP-1/NLRP3 signaling pathways and enhanced expression of miRNA-34a and LncRNA HOTAIR DOI

Merihane M. Nasr,

Sara A. Wahdan, Reem N. El‐Naga

et al.

NeuroToxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Quercetin protects against neuronal toxicity by activating the PI3K/Akt/GSK-3β pathway in vivo models of MPTP-induced Parkinson’s disease DOI Creative Commons
Y. Li,

Minghao Man,

Yiyuan Tian

et al.

Inflammopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Quercetin is a flavonoid commonly found in various fruits, vegetables, and grains. Studies have demonstrated that quercetin may help protect neuronal cells from damage caused by neurotoxins associated with Parkinson's disease, however, the underlying mechanism remains unclear. The current study aimed to investigate neuroprotective effects of MPTP-induced disease mouse models elucidate its mechanistic role modulating PI3K/Akt/GSK-3β signaling pathway. Male C57BL/6 mice were divided into control, MPTP, quercetin, MPTP + groups. protective on evaluated using animal behaviour analysis, histopathological examination, immunofluorescence staining. Subsequently, network pharmacology was utilized determine primary target sites disease. Finally, western blotting molecular docking techniques applied validate identified targets. significantly improved motor deficits mice, reduced atrophy, preserved TH+ dopaminergic neurons. Western analysis revealed upregulated anti-inflammatory IL-10 (p < 0.01) TGF-β while suppressing pro-inflammatory IL-1β iNOS 0.01). It activated pathway increasing phosphorylation PI3K 0.01), Akt GSK-3β also elevated anti-apoptotic Bcl-2 pro-apoptotic Bax Caspase-9 Molecular confirmed strong binding between (binding energies: -6.44 -5.24 kcal/mol). alleviates pathology inhibiting neuroinflammation, reducing apoptosis, activating These findings underscore potential as multi-target therapeutic agent for

Language: Английский

Citations

0
Role of Achyranthes aspera in neurodegenerative diseases: current evidence and future directions DOI Creative Commons

Huaiqing Luo,

S.H.Y. Wei,

Shujun Fu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 9, 2025

Neurodegenerative diseases are caused by the progressive degeneration of neurons and/or their myelin sheaths, ultimately leading to cognitive and motor dysfunction. Due complex pathogenesis limited efficacy therapeutic drugs, these have attracted significant attention. Achyranthes aspera, belongs family Amaranthaceae, has been extensively used in traditional folk medicines for treatment various ailments. Modern research revealed that aspera possesses pharmacological effects, including cardiocerebrovascular protection, immune regulation, antioxidation, anti-aging. Furthermore, neuroprotective effects confirmed numerous scientific studies. This review focuses on primary mechanisms prevention neurodegenerative diseases, as well potential application prospects. aims provide insights into clinical applications directions diseases.

Language: Английский

Citations

0
Suppressing nuclear translocation of microglial PKM2 confers neuroprotection via downregulation of neuroinflammation after mouse cerebral ischemia–reperfusion injury DOI
Jingchen Gao, Rui Liu,

Jun‐Chun Tang

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 112880 - 112880

Published: Aug. 16, 2024

Language: Английский

Citations

3
Neuroprotective effect of empagliflozin against doxorubicin-induced chemobrain in rats: interplay between SIRT-1/MuRF-1/PARP-1/NLRP3 signaling pathways and enhanced expression of miRNA-34a and LncRNA HOTAIR DOI

Merihane M. Nasr,

Sara A. Wahdan, Reem N. El‐Naga

et al.

NeuroToxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

0