Cited by Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: INSIG1

H3K18 lactylation-mediated SIX1 upregulation contributes to silica-induced epithelial-mesenchymal transition (EMT) of airway epithelial cells DOI

Songtao Liu,

Yiting He,

Linling Jin

et al.

Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 154109 - 154109

Published: March 1, 2025

Language: Английский

Citations

Astragalus mongholicusbunge and Angelica sinensis botanical drug decoction mitigates lung inflammation through NOX4/TGF-β1/SMAD3 signaling DOI

Zhifeng Yang,

Yuqian Chang, Tong Zhou

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Introduction Astragalus mongholicus bunge and Angelica sinensis are botanical drugs rich in beneficial nutrients health-promoting metabolites. Their roots can be decocted to a drug decoction “Danggui Buxue Tang (DBT),” demonstrating human anti-inflammatory Methods Here, we evaluate the mitigating function of DBT on lung inflammation early fibrosis rat model. The model was established by tracheal dripping silica suspension for 28 days. Positive intervention effects were observed dose-dependent manner after consecutive gavage (1.9, 3.8, 7.6 g/kg·bw/d) days 42 To explore underlying molecular mechanism. metabolites profiled using liquid chromatograph-mass spectrometer Chemspider database. Results Lung confirmed functional tests histopathologic analysis. Metabolite target analysis identified nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) as key regulating pulmonary fibrosis. Gene ontology (GO) estimated that oxidative stress, inflammatory response, myofibroblast differentiation, extracellular matrix (ECM) deposition major pathways DBT. KEGG found might modulate through transforming growth factor-β (TGF-β) pathway. GO chord signaling pathway maps revealed NOX4 contributes TGF-β regulation. vivo analyses significantly reduces protein expression, inhibits stress responses, TGF-β1, p-SMAD3, fibronectin 1 (FN1), smooth muscle actin (α-SMA) expression. Discussion These findings demonstrate lung-protecting identify critical proteins associated with

Language: Английский

Citations

Current Status and Prospects of the Pathological Mechanisms and Therapeutic Drugs for Silicosis DOI

艳张

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(04), P. 518 - 530

Published: Jan. 1, 2025

Language: Английский

Citations

Idiopathic pulmonary fibrosis microenvironment: Novel mechanisms and research directions DOI

Feng Gao, Lei Pan, Wei Liu

et al.

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 155, P. 114653 - 114653

Published: April 14, 2025

Language: Английский

Citations

Pharmacological Treatment of Interstitial Lung Diseases: A Novel Landscape for Inhaled Agents DOI

Vito D’Agnano, Fabio Perrotta,

Ramona Fomez

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1391 - 1391

Published: Oct. 29, 2024

Interstitial lung diseases (ILDs) encompass a heterogeneous group of over 200 disorders that require individualized treatment. Antifibrotic agents, such as nintedanib and pirfenidone, have remarkably revolutionized the treatment landscape patients with idiopathic pulmonary fibrosis (IPF). Moreover, approval has also expanded therapeutic options for progressive other than IPF. However, despite recent advances, current strategies based on antifibrotic agents and/or immunomodulation are associated non-negligible side effects. Therefore, several studies explored inhalation route aiming to spread higher local concentrations while limiting systemic toxicity. In this review, we examined currently available literature about preclinical clinical testing efficacy safety inhalation-based antifibrotics, immunomodulatory antioxidants, mucolytics, bronchodilators, vasodilator in ILDs.

Language: Английский

Citations

Insights on exploring the therapeutic potential and structural modification of Tetrandrine DOI

Liang Gong, He Liu, Bo Xu

et al.

Future Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 16(24), P. 2687 - 2700

Published: Nov. 28, 2024

Tetrandrine (Tet), a bisbenzylisoquinoline alkaloid from Stephania tetrandra, is noted for its diverse pharmacological effects but faces limitations in clinical use due to toxicity, poor solubility, and low bioavailability. Researchers are working address these issues by developing Tet derivatives with greater therapeutic potential through structural modification. Generally, key modifications include: 1) introducing an aromatic heterocycle or hydrophobic alkyne unit at the C-5 position can enhance antitumor activity; 2) adding amide, sulfonamide, electron-withdrawing group C-14 3) changing structure quaternary ammonium salt alter solubility greatly boost antibacterial 4) modification of C-12-methoxybenzyl motif metabolic stability thus change activity analogs; 5) simplification may result identification anticancer lead compounds novel mechanisms action. This review systematically summarizes strategies evaluates biological activities derivatives, aiming guide further optimization facilitate discovery analogs improved efficacy. The future direction possibility also considered.

Language: Английский

Citations

Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: INSIG1 DOI

Xiangnan Zhou,

Jingyuan Ning,

Rui Cai

et al.

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 11485 - 11503

Published: Dec. 1, 2024

Psoriasis represents a persistent, immune-driven inflammatory condition affecting the skin, characterized by lack of well-established biologic treatments without adverse events. Consequently, identification novel targets and therapeutic agents remains pressing priority in field psoriasis research.

Language: Английский

Citations