Single-cell expression and immune infiltration analysis of polyamine metabolism in breast cancer DOI Creative Commons
Xiliang Zhang, Hanjie Guo,

Xiao‐Long Li

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 16, 2024

Breast cancer is one of the most threatening women health diseases worldwide and its molecular heterogeneity offers a range response to therapy. The role polyamine metabolism receiving increasing attention. Polyamine not only plays an important in occurrence development breast cancer, but also interacts with tumor immune microenvironment. In this work, we applied single-cell RNA-sequencing (scRNA-seq) systems immunological approaches interrogate cell infiltration gene-to-gene co-expressions bulk transcriptomes cancer. We acquired sample data from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), evaluated status 22 types using CIBERSORTx tool, respectively. By leveraging Retrospective various technologies including gene expression methylation, identified 46 proliferation-associated co-expression modules weighted coexpression network analysis (WGCNA) approach along machine learning models which turn delineated single level expressions features that these selected module possessed. observed substantial cellular microenvironment, where lineage-specific patterns were highly associated progression. Moreover, correlated could function as regulators tumors for risk scores different patient groups defined by high- low-risk. findings study shed new light upon classification prognostic assessment personalized treatment

Language: Английский

CD44 Variant Expression in Follicular Cell-Derived Thyroid Cancers: Implications for Overcoming Multidrug Resistance DOI Creative Commons
Benny Mosoane, Michelle McCabe, Brandon S. Jackson

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(9), P. 1899 - 1899

Published: April 24, 2025

Thyroid cancer (TC) is a significant global health issue that exhibits notable heterogeneity in incidence and outcomes. In low-resource settings such as Africa, delayed diagnosis limited healthcare access exacerbate mortality rates. Among follicular cell-derived thyroid cancers—including papillary (PTC), (FTC), anaplastic (ATC), poorly differentiated (PDTC) subtypes—the role of CD44 variants has emerged critical factor influencing tumor progression multidrug resistance (MDR). CD44, transmembrane glycoprotein, its splice (CD44v) mediate cell adhesion, migration, survival, contributing to stem (CSC) maintenance therapy resistance. Differential expression patterns isoforms across TC subtypes have shown diagnostic, prognostic, therapeutic implications. Specifically, CD44v6 PTC been correlated with metastasis aggressive behavior, while FTC, aids distinguishing malignant from benign lesions. Furthermore, contributes MDR through enhanced drug efflux via ABC transporters, apoptosis evasion, CSC the Wnt/β-catenin PI3K/Akt pathways. Targeted therapies against monoclonal antibodies, hyaluronic acid-based nanocarriers, gene-editing technologies hold promise overcoming MDR. However, despite mounting evidence supporting CD44-targeted strategies various cancers, research on this potential remains limited. This review synthesizes existing knowledge variant cancers highlights mitigate MDR, particularly high-burden regions, thereby improving patient outcomes survival.

Language: Английский

Citations

0
Targeting cancer stem cells by TPA leads to inhibition of refractory sarcoma and extended overall survival. DOI Creative Commons

Karina Galoian,

Daniel Bilbao, Carina Denny

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 32(4), P. 200905 - 200905

Published: Nov. 6, 2024

Refractory cancer recurrence in patients is a serious challenge modern medicine. Tumor regrowth more aggressive and invasive drug-resistant form caused by specific sub-population of tumor cells defined as stem (CSCs). While the role CSCs relapse recognized, signaling pathways CSCs-driven chemoresistance are less well understood. Moreover, there no effective therapeutic strategies that involve inhibition responsible for drug resistance. There clinical need to develop new therapies with refractory sarcomas, particularly fibrosarcoma. These tumors, poor overall survival, do not respond conventional therapies. Standard systemic chemotherapy these tumors includes doxorubicin (DOX). A Tyr peptide analog (TPA), developed our laboratory, specifically targets drastically reducing expression polycomb group protein enhancer zester (EZH2) its downstream targets, ALDH1A1 Nanog.

Language: Английский

Citations

0
Single-cell expression and immune infiltration analysis of polyamine metabolism in breast cancer DOI Creative Commons
Xiliang Zhang, Hanjie Guo,

Xiao‐Long Li

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Nov. 16, 2024

Breast cancer is one of the most threatening women health diseases worldwide and its molecular heterogeneity offers a range response to therapy. The role polyamine metabolism receiving increasing attention. Polyamine not only plays an important in occurrence development breast cancer, but also interacts with tumor immune microenvironment. In this work, we applied single-cell RNA-sequencing (scRNA-seq) systems immunological approaches interrogate cell infiltration gene-to-gene co-expressions bulk transcriptomes cancer. We acquired sample data from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO), evaluated status 22 types using CIBERSORTx tool, respectively. By leveraging Retrospective various technologies including gene expression methylation, identified 46 proliferation-associated co-expression modules weighted coexpression network analysis (WGCNA) approach along machine learning models which turn delineated single level expressions features that these selected module possessed. observed substantial cellular microenvironment, where lineage-specific patterns were highly associated progression. Moreover, correlated could function as regulators tumors for risk scores different patient groups defined by high- low-risk. findings study shed new light upon classification prognostic assessment personalized treatment

Language: Английский

Citations

0