Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 17, 2024
Ferroptosis is a form of regulated cell death. The accumulation iron in the brain linked to trigger ferroptosis after an ischaemic stroke (IS). Naoqing formula (NQ) traditional Chinese medicine metabolites with clinical function activating blood circulation, which applied treat IS clinically China.
Language: Английский
Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: 231, P. 153 - 162
Published: Feb. 27, 2025
Language: Английский
Citations
0
Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(3)
Published: March 18, 2025
Ischemic stroke (IS) constitutes a major threat to human health. Vascular recanalization by intravenous thrombolysis and mechanical remain the most significant effective methods for relief of ischemia. Key elements these treatments include achieving blood-vessel recanalization, restoring brain-tissue reperfusion, preserving ischemic penumbra. However, in therapeutic goals vascular secondary damage brain tissue from cerebral ischemia-reperfusion injury (CIRI) must also be addressed. Despite advancements understanding pathological processes associated with CIRI, interventions prevent its onset progression are still lacking. Recent research has indicated that mitophagy ferroptosis critical mechanisms development significantly contribute IS CIRI because common targets co-occurrence mechanisms. Therefore, exploring summarizing potential connections between during is crucial. In present review, we mainly focused on mitochondrial autophagy ferroptosis, their interaction, CIRI. We believe data show strong relationship interactive regulation. This information may underpin new approaches prevention treatment subsequent
Language: Английский
Citations
0
Aging Cell, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 29, 2024
Abstract The unprecedented rise in global ambient temperatures the last decade has significantly impacted human health, yet how heat exposure affects development of sarcopenia remains enigmatic. Here, we demonstrate that chronic induces skeletal muscle volume loss, leading to strength and functional decline mice. microbiota composition heat‐exposed mice was analyzed using 16S ribosomal DNA analysis. Liquid chromatography‐mass spectrometry (LC–MS) used explore effects on blood metabolome further analyze correlation between metabolism gut microbiota. Transplantation from germ‐free sufficient increase adverse function host. Mechanistically, an untargeted metabolomics strategy, reveal altered due high is associated with elevated serum levels homocitrulline. Homocitrulline causes mitochondrial dysfunction myocytes by exacerbating ferroptosis levels. And Nrf2 activator (Oltipraz) supplementation alleviates atrophy induced exposure. Our findings detrimental provide new strategies for treating sarcopenia.
Language: Английский
Citations
2
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 17, 2024
Ferroptosis is a form of regulated cell death. The accumulation iron in the brain linked to trigger ferroptosis after an ischaemic stroke (IS). Naoqing formula (NQ) traditional Chinese medicine metabolites with clinical function activating blood circulation, which applied treat IS clinically China.
Language: Английский
Citations
1