Targeting breast tumor extracellular matrix and stroma utilizing nanoparticles DOI

Faris Anad Muhammad,

Farag M. A. Altalbawy,

Viralkumar Mandaliya

et al.

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Language: Английский

Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization DOI Creative Commons
Zhenxuan Sun, Jie Liu, Peng Ge

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 1395 - 1412

Published: Jan. 1, 2025

Explore the therapeutic effect and molecular mechanism of rhein on severe acute pancreatitis associated lung injury (SAP-ALI). The SAP-ALI rat model was constructed by retrograde injection 5% sodium taurocholate into pancreaticobiliary duct, pulmonary microvascular endothelial cell (PMVEC) induced LPS. potential effects appropriate dosages PMVEC were investigated in both vivo vitro experiments. Furthermore, regulatory role MARK4 related pathological process confirmed some experimental methods. RNA sequencing analysis performed to explore downstream genes MARK4. Moreover, validated through docking rescue Rhein intervention had triggered SAP may contribute modulation microtubule structure. Compared with LPS stimulation, a total 2081 differentially expressed identified after knockdown. results experiments indicated that exert its protective targeting regulate structure MARK4, thereby alleviating LPS-induced injury.

Language: Английский

Citations

0
Regulation of cancer-associated fibroblasts for enhanced cancer immunotherapy using advanced functional nanomedicines: an updated review DOI Creative Commons
Tingting Liao, Xiaoxiao Chen,

Fengkai Qiu

et al.

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 4, 2025

The tumor microenvironment (TME) is a complex and dynamic ecosystem that plays critical role in cancer progression. It comprises various cell types, including immune cells, stromal cells. Among these, cancer-associated fibroblasts (CAFs) represent heterogeneous population with diverse origins, phenotypes, functions. Activated CAFs secrete multiple factors promote growth, migration, angiogenesis, contribute to chemoresistance. Additionally, extracellular matrix (ECM) components, such as collagen, which form physical barrier hinders the penetration of chemotherapeutic immunotherapeutic agents. This ECM also influences infiltration, impeding their ability effectively target As result, modulating activity has emerged promising strategy enhance efficacy immunotherapy. Nano-delivery systems, constructed from nanomaterials high targeting specificity biocompatibility, offer compelling approach deliver therapeutic agents or immunomodulatory directly CAFs. modulation can alter CAF function, reduce tumor-promoting effects, thereby improve outcomes review provides an in-depth exploration functions, interactions within TME, particularly context suppression. Furthermore, it discusses potential applications functional nanocarrifers enhancing effectiveness immunotherapy, highlighting significant progress nanotechnology this area.

Language: Английский

Citations

0
Exploring hesperidin: an effective naturalphytomedicine for combating breast cancer DOI

S. Chitra,

Saheb Ali

Natural Product Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 2

Published: Nov. 18, 2024

Language: Английский

Citations

0
Targeting breast tumor extracellular matrix and stroma utilizing nanoparticles DOI

Faris Anad Muhammad,

Farag M. A. Altalbawy,

Viralkumar Mandaliya

et al.

Clinical & Translational Oncology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 18, 2024

Language: Английский

Citations

0