Naringenin Inhibits PRV Replication by Regulating the TLR4/NF-κB Pathway Mediated Inflammatory Response DOI

Juanjuan Xu,

Zhiying Wang, Zhiyuan Ren

et al.

Veterinary Microbiology, Journal Year: 2025, Volume and Issue: 306, P. 110563 - 110563

Published: May 21, 2025

Language: Английский

Quercetin as a therapeutic agent for acute pancreatitis: a comprehensive review of antioxidant, anti-inflammatory, and immunomodulatory mechanisms DOI Creative Commons
Zhigang Jiang,

Gamar Lhamo,

Min Ma

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Acute pancreatitis (AP) is a severe inflammatory disorder of the pancreas, characterized by high morbidity and mortality rates. Despite significant advancements in understanding pathophysiological mechanisms AP, current treatment options still face considerable limitations. Recent studies have underscored therapeutic potential quercetin, natural flavonoid, due to its potent antioxidant, anti-inflammatory, immunomodulatory properties, positioning it as promising candidate for AP. This review explores effects quercetin on highlighting antioxidant activities, role immune modulation, protective pancreatic tissue. Furthermore, examines quercetin's multi-target advantages over conventional therapies, such N-acetylcysteine corticosteroids. Although preliminary suggest that can alleviate inflammation oxidative stress clinical evidence remains limited. One main challenges application low bioavailability. Future research should focus strategies enhance bioavailability conducting large-scale randomized controlled trials more comprehensively assess efficacy safety

Language: Английский

Citations

1
Procyanidin B2 alleviates damage to mouse testicular tissue after freezing by inhibiting oxidative stress and apoptosis DOI

Guorui Cao,

Chunyuan Li, Jian Zhang

et al.

Cryobiology, Journal Year: 2025, Volume and Issue: 118, P. 105196 - 105196

Published: Feb. 20, 2025

Language: Английский

Citations

0
Tetramethylpyrazine alleviates acute pancreatitis inflammation by inhibiting pyroptosis via the NRF2 pathway DOI Creative Commons

Huangen Li,

Yi Gao,

Minglian Huang

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 23, 2025

Tetramethylpyrazine (TMPZ), an active alkaloid derived from traditional Chinese medicine, has shown anti-inflammatory and anti-pyroptotic properties. However, its role in acute pancreatitis (AP)-induced pyroptosis remains unclear. This study aims to investigate the effects of TMPZ on AP-induced potential mechanisms. A cerulein-induced AP rat model was used evaluate TMPZ's protective vivo, mechanisms were explored using AR42J cells vitro. Pancreatic injury assessed by hematoxylin-eosin staining, TUNEL assay, serum biochemistry. Transmission electron microscopy, immunofluorescence, Western blotting, quantitative real-time polymerase chain reaction (RT-qPCR) conducted examine related signaling pathways. Cytotoxicity apoptosis measured CCK-8, LDH assays, Hoechst 33342/PI staining. The NRF2 further evaluated siRNA. alleviated pancreatic histopathological damage, reduced apoptosis, decreased amylase levels pro-inflammatory cytokines (IL-1β, IL-18). also suppressed inhibiting NLRP3 inflammasome activation downregulating pyroptosis-related proteins (NLRP3,caspase-1, ASC, GSDMD) while upregulating HO-1 expression. siRNA attenuated pyroptosis-inhibitory effects, confirming involvement pathway. mitigates inflammation modulating via These findings suggest therapeutic for AP.

Language: Английский

Citations

0
Naringenin Inhibits PRV Replication by Regulating the TLR4/NF-κB Pathway Mediated Inflammatory Response DOI

Juanjuan Xu,

Zhiying Wang, Zhiyuan Ren

et al.

Veterinary Microbiology, Journal Year: 2025, Volume and Issue: 306, P. 110563 - 110563

Published: May 21, 2025

Language: Английский

Citations

0