Plasma miR-145-5p Levels and Risk of Future Cancer—Results from the HUNT Study DOI Open Access
Christopher Antoun, Júlia Oto, Vânia M. Morelli

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2191 - 2191

Published: Feb. 28, 2025

MicroRNA-145-5p (miR-145) has been reported to regulate multiple oncogenes and is considered a tumor suppressor. However, it remains unknown whether the level of plasma miR-145 can serve as risk biomarker for future cancer. Using population-based cohort (n = 1740) derived from Trøndelag Health Study (HUNT), we investigated levels were associated with (1) first life-time cancer, (2) cancer stage at diagnosis, (3) 2-year all-cause mortality after diagnosis. Cox regression analysis was used estimate hazard ratios (HR) 95% confidence intervals (CI). Our findings showed that individuals in highest quartile had 44% increased developing compared those lowest quartile, independent age, sex, body mass index, or smoking status (HR 1.44, CI 1.03-2.00 p < 0.05). no association observed between quartiles being diagnosed metastatic suggest high are without affecting severity diagnosis short-term prognosis.

Language: Английский

Plasma miR-145-5p Levels and Risk of Future Cancer—Results from the HUNT Study DOI Open Access
Christopher Antoun, Júlia Oto, Vânia M. Morelli

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 2191 - 2191

Published: Feb. 28, 2025

MicroRNA-145-5p (miR-145) has been reported to regulate multiple oncogenes and is considered a tumor suppressor. However, it remains unknown whether the level of plasma miR-145 can serve as risk biomarker for future cancer. Using population-based cohort (n = 1740) derived from Trøndelag Health Study (HUNT), we investigated levels were associated with (1) first life-time cancer, (2) cancer stage at diagnosis, (3) 2-year all-cause mortality after diagnosis. Cox regression analysis was used estimate hazard ratios (HR) 95% confidence intervals (CI). Our findings showed that individuals in highest quartile had 44% increased developing compared those lowest quartile, independent age, sex, body mass index, or smoking status (HR 1.44, CI 1.03-2.00 p < 0.05). no association observed between quartiles being diagnosed metastatic suggest high are without affecting severity diagnosis short-term prognosis.

Language: Английский

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