Proarrhythmic Lipid Inflammatory Mediators: Mechanisms in Obesity Arrhythmias

Journal of Cellular Physiology, Journal Year: 2025, Volume and Issue: 240(2)

Published: Feb. 1, 2025

ABSTRACT The prevalence of obesity and associated metabolic disorders such as diabetes is rapidly increasing; therefore, concerns regarding their cardiovascular consequences, including cardiac arrhythmias, are rising. As progresses, the excessively produced lipids accumulate in unconventional areas epicardial adipose tissue (EAT) around myocardium. Metabolic alterations contribute to transformation these ectopic fat deposits into arrhythmogenic substrates. However, despite advances therapeutic approaches, particularly lowering EAT volume thickness through sodium‐glucose co‐transporter‐2 (SGLT2) inhibitors glucagon‐like peptide‐1 (GLP‐1) receptor agonists, obese diabetic patients still suffer from fatal arrhythmias that may lead sudden death. Therefore, an investigation how unappreciated underlying pathways lipid mediators tissues proinflammatory substrates significance. Leukotriene B4 (LTB4) eicosanoid derived arachidonic acid acts a mediator. LTB4 has recently been identified be with ion channel modulations conditions diabetes. increases circulatory free fatty acids (FFAs) adipocyte hypertrophy. also interferes insulin signaling pathways, instigating resistance (IR). In addition, LTB4, potent chemoattractant, contributes mobilization immune cells monocytes promotes inflammatory macrophage polarization dysfunction. Thus, this review provides comprehensive overview LTB4's obesity; illustrates might channels, currents, arrhythmias; shows they pose target for metabolic‐associated arrhythmias.

Language: Английский

Causal association between varicose veins and atrial fibrillation: A 2-sample bidirectional Mendelian randomization study

Medicine, Journal Year: 2025, Volume and Issue: 104(7), P. e41466 - e41466

Published: Feb. 14, 2025

This study selected genome-wide association data from the FinnGen database and utilized a bidirectional 2-sample Mendelian randomization (MR) method to explore causal between varicose veins (VV) atrial fibrillation (AF). Inverse variance weighted (IVW) was used as primary analytical assess relationship VV AF, supplemented by Weighted median, MR-Egger Simple 1mode. Cochran’s Q test, regression intercept pleiotropy residual sum outlier were sensitivity analyses detect heterogeneity multilevel pleiotropy. Additionally, reverse MR conducted analyze AF VV. The IVW indicated positive (odds ratio = 1.1571, 95% confidence interval 1.0810–1.2384, P 2.59 × 10 −5 ). Reverse analysis shows no potential relationships. results showed significant effect of on suggesting that may increase risk developing AF. It also elaborates common factors pathophysiological conditions

Language: Английский